tag:blogger.com,1999:blog-30295092428597211522024-03-14T00:38:36.796-07:00Bhaskar Health: trustworthy health news and medical informationStay informed on the latest health news and medical education with Bhaskar Health. Enhance your knowledge and stay up-to-date with our information.Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comBlogger2748125tag:blogger.com,1999:blog-3029509242859721152.post-17380349354245049762024-02-09T22:18:00.000-08:002024-02-09T22:47:13.930-08:00Office Chair Risk: 16% Risk of Early Death<p><span style="font-family: Sora;">Did you know that spending your day glued to your office chair could lead you closer to death? Yeah, it's a bit of a shocker, but research suggests that living the desk jockey life can hike up your risk of early death by a startling 16 per cent.</span></p><p><span style="font-family: Sora;"><br /></span></p><p></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjZTZhR-gKSNb8hDicdE1hNfZ1ei4ZBckrC3tq8iRTr1xplCVBPSJUE85CAfc0wyQNcGQOi2cE3DfelcQR2zRdGscKhTUP0Uh8DVJbVbmfKD5yGItKN9SzPPxhi2bboJ_nxPhtREctd2pl1kGdBjEjXIXpB6xraHTuVJUHFoW7DPwnpypYieTAbFJANUvo/s642/images%20(1)%20(9).jpeg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="478" data-original-width="642" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjZTZhR-gKSNb8hDicdE1hNfZ1ei4ZBckrC3tq8iRTr1xplCVBPSJUE85CAfc0wyQNcGQOi2cE3DfelcQR2zRdGscKhTUP0Uh8DVJbVbmfKD5yGItKN9SzPPxhi2bboJ_nxPhtREctd2pl1kGdBjEjXIXpB6xraHTuVJUHFoW7DPwnpypYieTAbFJANUvo/s16000/images%20(1)%20(9).jpeg" /></a></div><span style="font-family: Sora;"><br /></span><p></p><p><span style="font-family: Sora;">The research published in the <a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2814094#:~:text=Findings%20In%20this%20cohort%20study,did%20not%20sit%2C%20even%20after"><b>journal JAMA Network</b></a> Open and conducted in Taiwan with 4,81,688 participants over approximately 13 years revealed that:</span></p><p></p><span style="font-family: Sora;">• those who predominantly stayed glued to their workstations faced a 34 per cent higher risk of dying from cardiovascular disease (CVD), and</span><div><span style="font-family: Sora;"><br /></span><span style="font-family: Sora;">• a 16 per cent increased likelihood of death from all causes </span><span style="font-family: Sora;">compared to their more active counterparts</span><br /><div><span style="font-family: Sora;"><br /></span></div><p></p><h2 style="text-align: left;"><span style="font-family: Sora;">Let's dive into what's going on here.</span></h2><p><span style="font-family: Sora;">When we're sitting, we're not taking a load off our feet; but putting a load on our health. Our bodies are designed to move, and when we don't, things start to go haywire.</span></p><p><span style="font-family: Sora;">Obesity, high blood pressure, high blood sugar, excess body fat around the waist, and unhealthy cholesterol levels are all part of the not-so-fun package that comes with too much sitting. They're like the sinister squad of metabolic syndrome, and they're all linked to heart disease and cancer.</span></p><p><span style="font-family: Sora;">Our bodies are designed to move, and when we don't, things start to go haywire.</span></p><p><span style="font-family: Sora;"><i>Wait, there’s more. Studies have found that if you're clocking in more than eight hours of seat time a day without any physical activity, your risk of kicking the bucket is similar to the risks posed by obesity and smoking. That's right, smoking!</i></span></p><p><span style="font-family: Sora;">And if you thought hitting the gym after work would undo all the threats posed by sitting, think again. Even if you're sweating it out during your off-hours, sitting for prolonged periods can still affect your health.</span></p><p><span style="font-family: Sora;"><br /></span></p><h2 style="text-align: left;"><span style="font-family: Sora;">Deskercise</span></h2><p><span style="font-family: Sora;">It is a term that combines "desk" and "exercise", referring to physical activities that can be performed while sitting at a desk or in an office environment.</span></p><p><span style="font-family: Sora;">These exercises are designed to promote health and fitness for individuals who spend a significant portion of their day seated, often due to the nature of their work.</span></p><p><span style="font-family: Sora;"><br /></span></p><p></p><div class="separator" style="clear: both; text-align: center;"><iframe allowfullscreen="" class="BLOG_video_class" height="266" src="https://www.youtube.com/embed/y2TGWaW7ge8" width="320" youtube-src-id="y2TGWaW7ge8"></iframe></div><br /><span style="font-family: Sora;"><br /></span><p></p><p><span style="font-family: Sora;">Deskercise routines typically include stretches and strength-building movements that can be integrated into the workday without requiring special equipment or a lot of space.</span></p><p><span style="font-family: Sora;">Deskercise refers to physical activities that can be performed while sitting at a desk.</span></p><p><span style="font-family: Sora;"><br /></span></p><h3 style="text-align: left;"><span style="font-family: Sora;">Conclusion </span></h3><p><span style="font-family: Sora;">Experts have a clear message: less sitting and more moving are essential for better health. Reducing sedentary behaviour not only lowers the risk of premature death, but also contributes to the prevention of metabolic syndrome, obesity, and other associated health conditions.</span></p><p><span style="font-family: Sora;"><br /></span></p><p><span style="font-family: Sora;"><b>Reference</b>: <a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2814094#:~:text=Findings%20In%20this%20cohort%20study,did%20not%20sit%2C%20even%20after" target="_blank">Jama Network</a> </span></p></div>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-49940697648656404142024-02-08T04:37:00.000-08:002024-02-08T21:19:00.483-08:00How to use Shilajit for gym before or after workout for bodybuilding?<p><span style="font-family: DM Sans; font-size: 18.6667px; letter-spacing: 0em;">Shilajit is an excellent Ayurvedic supplement which does wonders for your health. Shilajit offers abundant health benefits to you. Rich in several vital minerals, shilajit promotes strength and endurance. It has more than 85 trace elements necessary for human health.</span></p><div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 18.6667px; letter-spacing: 0em;">Shilajit is an organic supplement that increases muscular growth, strength, and endurance. </span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans;"><span style="font-size: 18.6667px; letter-spacing: 0em;">In this blog, we will discuss why many fitness enthusiasts use it for bodybuilding. But knowing the </span><a href="https://rasayanam.in/when-to-take-shilajit-dosage-best-time/" style="color: black; font-size: 18.6667px; font-weight: 700; letter-spacing: 0em;">best time to take shilajit for bodybuilding</a><span style="font-size: 18.6667px; letter-spacing: 0em;"> is a must to build more strength and stamina. </span></span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 29.3333px; font-weight: 700; letter-spacing: 0em;">What is Shilajit? </span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 18.6667px; letter-spacing: 0em;">Shilajit is a black tar-like substance. It is found mainly in the Himalayas and is used in Ayurvedic medicine. It is rich in fulvic acid and other minerals. </span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans;"><span style="font-size: 18.6667px; letter-spacing: 0em;">Shilajit helps people increase their energy and improve </span><span style="font-size: 17.3333px; letter-spacing: 0em;">cognitive function, vitality, stamina, and sexual wellness. </span></span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 29.3333px; font-weight: 700; letter-spacing: 0em;">Shilajit Nutritional Value</span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 18.6667px; letter-spacing: 0em;">Shilajit is rich in several vital minerals. It promotes strength and endurance. It has more than 85 trace elements that are necessary for human health. It includes humic substance (produced via the lengthy process of breakdown and transformation of biomass waste), fulvic acid (approximately 60–80%), selenium (renowned for its anti-ageing qualities), zinc, magnesium, potassium, and iron. </span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 29.3333px; font-weight: 700; letter-spacing: 0em;">Benefits of Shilajit In General Use</span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 18.6667px; letter-spacing: 0em;">There are too many benefits of shilajit to list them all. It has fulvic acid, which helps you replenish your iron levels and experience increased vitality, energy, mental clarity, stamina, and sexual potency.</span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 18.6667px; letter-spacing: 0em;">There are several shilajit benefits for women and men; thus, these advantages are not gender specific. Shilajit has several advantages for women: it can aid with arthritis, alleviate anaemia, enhance sexual and bone health, improve skin and hair health, and much more. </span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 18.6667px; letter-spacing: 0em;">Shilajit is popular among fitness enthusiasts and bodybuilders since it promotes muscle growth and improves strength, endurance, and muscle recovery after a workout. Since Shilajit is an organic substance, athletes prefer it over fake health pills even more. Many bodybuilders use shilajit before or after a workout to ensure maximum benefit.</span></p><p><span style="font-family: DM Sans; font-size: 18.6667px; letter-spacing: 0em;"><br /></span></p><p></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiwD03A3NCQVePceoEleQ3blrVvHvUlgwjh6squTYI-rf41NgvzvvGLCgF2Sa5CgizKMT2HSaxhyvkOQuc7bhNaHDhXswVmMlcQRfjU7-QinpsZIQPgGzDjyp8CDkmmt726wvfHmFDackX9h60GI79d0dKXV543QShurV4v4Vq1iJuxI_va5bQquUXWbqU/s1379/rasayanam%20shilajeet.png" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="776" data-original-width="1379" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiwD03A3NCQVePceoEleQ3blrVvHvUlgwjh6squTYI-rf41NgvzvvGLCgF2Sa5CgizKMT2HSaxhyvkOQuc7bhNaHDhXswVmMlcQRfjU7-QinpsZIQPgGzDjyp8CDkmmt726wvfHmFDackX9h60GI79d0dKXV543QShurV4v4Vq1iJuxI_va5bQquUXWbqU/s16000/rasayanam%20shilajeet.png" /></a></div><span style="font-family: DM Sans; font-size: 18.6667px; letter-spacing: 0em;"><br /></span><p></p><p></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 29.3333px; font-weight: 700; letter-spacing: 0em;">How To Use Shilajit For Gym?</span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans;"><span style="font-size: 18.6667px; letter-spacing: 0em;">Shilajit can prove to be essential. Shilajit will benefit you in recovery, strength, mental focus, energy and stress reduction. But </span><a href="https://rasayanam.in/how-to-use-shilajit-as-a-pre-workout-supplement/" style="color: black; font-size: 18.6667px; font-weight: 700; letter-spacing: 0em;">how to use shilajit for gym</a><span style="font-size: 18.6667px; font-weight: 700; letter-spacing: 0em;"> </span><span style="font-size: 18.6667px; letter-spacing: 0em;">will depend on your dietary requirements. Shilajit has fulvic acid and other minerals which will help you in the long run. </span></span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 29.3333px; font-weight: 700; letter-spacing: 0em;">Benefits of shilajit for bodybuilding</span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans;"><span style="font-size: 20px; letter-spacing: 0em;">There are many benefits of shilajit. For fitness enthusiasts, </span><a href="https://rasayanam.in/should-shilajit-be-taken-before-or-after-a-workout/" style="color: black; font-size: 18.6667px; font-weight: 700; letter-spacing: 0em;">shilajit before or after workout</a><span style="font-size: 18.6667px; letter-spacing: 0em;"> is an essential part of their diet. It contains necessary nutrients and minerals that help muscle recovery, increase energy and much more. </span></span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans;"><span style="font-size: 18.6667px; letter-spacing: 0em;">The following are the </span><span style="font-size: 20px; letter-spacing: 0em;">benefits of shilajit for bodybuilding:- </span></span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 26.6667px; font-weight: 700; letter-spacing: 0em;">Shilajit Resupply Electrolyte </span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 18.6667px; letter-spacing: 0em;">Shilajit helps restore the quantity of electrolytes lost during physical activity. We sweat out the vital electrolytes our body needs to maintain the water balance and control muscle contractions, nerve impulses, and metabolism while exercising. </span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 18.6667px; letter-spacing: 0em;">Shilajit's high mineral content will aid in preserving endurance and physical performance by replenishing electrolytes.</span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 26.6667px; font-weight: 700; letter-spacing: 0em;">Shilajit Increases Energy </span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 18.6667px; letter-spacing: 0em;">The main ingredient in shilajit is fulvic acid, which relieves muscular soreness—a natural side effect of exercise. Shilajit is also necessary for bodybuilding since it increases your energy levels. </span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 26.6667px; font-weight: 700; letter-spacing: 0em;">Collagen Booster </span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 18.6667px; letter-spacing: 0em;">Shilajit helps our bodies by increasing the amount of collagen necessary for strong, supple, and healthy joints. For connective tissues such as tendons, ligaments, bones, and joints, collagen is an essential protein. Collagen levels in the body decline with age; unhealthy lifestyle choices like smoking, excessive sun exposure, and overindulging in refined sugar can all contribute to this. To increase your collagen levels, you should use shilajit in your diet when using bodybuilding supplements. </span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 26.6667px; font-weight: 700; letter-spacing: 0em;">Absorption Of Iron And Other Minerals </span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 18.6667px; letter-spacing: 0em;">Shilajit facilitates improved iron and protein absorption, which promotes muscular growth. Iron aids muscle recovery and weariness after exercise and is necessary for producing red blood cells and transporting oxygen throughout the body to boost energy levels. </span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 29.3333px; font-weight: 700; letter-spacing: 0em;">What is the best time to shilajit for bodybuilding? </span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 18.6667px; letter-spacing: 0em;">Shilajit before or after workout is essential to gain maximum muscle strength and mass. It proves to be a good before and after workout food as it will provide you with many important nutrients that your body needs. </span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 18.6667px; letter-spacing: 0em;">But, consuming shilajit before or after workout will not benefit you altogether. You need to be cautious about the timing of your consumption as well. Whether you are using shilajit before or after workout is according to your dietary and body requirements.</span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans;"><span style="font-size: 18.6667px; letter-spacing: 0em;">Shilajit will benefit you in recovery, strength, mental focus, energy and stress reduction. You need to consult your doctor as to when you should </span><span style="font-size: 18.6667px; letter-spacing: 0em;">consume.</span></span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 18.6667px; letter-spacing: 0em;">There are many benefits to shilajit, but you should choose it cautiously because there are many contaminated shilajit available. Purchase the Rasayanam shilajit, which comes from the 18,000-foot Gilgit mountain range and is regarded as the strongest and purest shilajit on the market.</span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans;"><span style="font-size: 18.6667px; letter-spacing: 0em;">Free of harmful heavy metals, including arsenic, cadmium, mercury, and lead, </span><span style="font-size: 18.6667px; font-weight: 700; letter-spacing: 0em;">rasayanam ayurveda shilajit</span><span style="font-size: 18.6667px; letter-spacing: 0em;"> is available as a resin. </span></span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans;"><span style="font-size: 18.6667px; letter-spacing: 0em;">It carries FSSAI approval and a clinical test report to help the consumers know about the authenticity of </span><a href="https://rasayanam.in/buy/shilajit/" style="color: black; font-size: 18.6667px; font-weight: 700; letter-spacing: 0em;">rasayanam shilajit</a><span style="font-size: 18.6667px; letter-spacing: 0em;">.</span></span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 26.6667px; font-weight: 700; letter-spacing: 0em;"><a href="https://rasayanam.in/buy/shilajit/" target="_blank">Infographic</a></span></p><p><br /></p><table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto;"><tbody><tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj4HQy97ErM5YWWuz8-R0Xkg2qqDUPo4RH8H7qzhj4y4iigDckVbXVboWcCOd-wwKwyU6B4PyBin3wd_gbYfJNoi0aAlxy7tLQwplOIhIncMtO6Uu9u2DhPz99OSCuwvJYnknWqB1WbTmroPTOKpc9_XrThjjlVjrSEsoOQB8j-jb_FsgS-f9202vhEM3Q/s2000/rasayanam%20shilajit%20infographic.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img border="0" data-original-height="2000" data-original-width="800" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj4HQy97ErM5YWWuz8-R0Xkg2qqDUPo4RH8H7qzhj4y4iigDckVbXVboWcCOd-wwKwyU6B4PyBin3wd_gbYfJNoi0aAlxy7tLQwplOIhIncMtO6Uu9u2DhPz99OSCuwvJYnknWqB1WbTmroPTOKpc9_XrThjjlVjrSEsoOQB8j-jb_FsgS-f9202vhEM3Q/s16000/rasayanam%20shilajit%20infographic.jpg" /></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Source: <a href="https://rasayanam.in/buy/shilajit/">https://rasayanam.in/buy/shilajit/</a></td></tr></tbody></table><p><br /></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 26.6667px; font-weight: 700; letter-spacing: 0em;">Conclusion</span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 18.6667px; letter-spacing: 0em;">Shilajit before or after workout is an essential part of their diet. It contains necessary nutrients and minerals that help muscle recovery and increase energy. </span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans;"><span style="font-size: 18.6667px; letter-spacing: 0em;">But </span><span style="font-size: 18.6667px; font-weight: 700; letter-spacing: 0em;">how to use shilajit for gym</span><span style="font-size: 18.6667px; letter-spacing: 0em;"> will depend on your dietary requirements. Shilajit has fulvic acid and other minerals which will help you in the long run. But you should choose it carefully because there are many contaminated shilajit available. Purchase the Rasayanam shilajit, which comes from the 18,000-foot Gilgit mountain range and is regarded as the strongest and purest shilajit on the market.</span></span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 26.6667px; font-weight: 700; letter-spacing: 0em;">Commonly Asked Questions</span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 21.3333px; font-weight: 700; letter-spacing: 0em;">Q. Is Shilajit good for muscle building? </span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 17.3333px; letter-spacing: 0em;">A. Shilajit facilitates improved iron and protein absorption, which promotes muscular growth. Iron aids muscle recovery and weariness after exercise and is necessary for producing RBCs, supplying oxygen to boost energy levels. </span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 21.3333px; font-weight: 700; letter-spacing: 0em;">Q. Does shilajit make you strong?</span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 17.3333px; letter-spacing: 0em;">A. The high mineral content of Shilajit helps maintain the vigour and power of muscles. Its ability to enhance oxygen transport to tissues may postpone the weariness that comes with hard physical work. Frequent Shilajit ingestion may result in improved general fitness and endurance. </span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans;"><span style="font-size: 21.3333px; font-weight: 700; letter-spacing: 0em;">Q. </span><span style="color: #202124; font-size: 21.3333px; font-weight: 700; letter-spacing: 0em;">What are the results of Shilajit in bodybuilding?</span></span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans; font-size: 18.6667px; letter-spacing: 0em;">A. Shilajit is popular among fitness enthusiasts and bodybuilders since it promotes muscle growth and improves strength, endurance, and muscle recovery after a workout. </span></p></div><div style="direction: ltr; line-height: 1.5; margin-left: 0px;"><p><span style="font-family: DM Sans;"><span style="color: #0e101a; font-size: 17.3333px; font-weight: 700; letter-spacing: 0em;">Disclaimer: </span><span style="color: #0e101a; font-size: 17.3333px; letter-spacing: 0em;">This write-up intends to provide general information and should not be considered professional advice. Kindly consult your healthcare professional for accurate dosage and modifications.</span></span></p></div></div>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-3185251569814566752023-12-31T17:52:00.000-08:002023-12-31T17:53:59.030-08:00My New Year Message to Patients and their Families<p><span style="font-family: Noto Sans; font-size: medium;"><b>CARE Physiotherapy Clinic, Jhansi</b> wants to send our warmest wishes to all our followers, supporters, friends, and family. Thank you for your continuous support throughout the year! Wishing you all a very Happy New Year. Here's to more exciting adventures together in 2024!</span></p><p><span style="font-family: Noto Sans; font-size: medium;"><br /></span></p><p></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiaS-K_BwSmk3G4uMVKfxP2SNMAlIubrVB554aXG7rzv0rOLe5fxTDzdHJowzmxAhRaRZaHSerr1199Sbvt-yXqOZO7-TQa1VmgnLKJgLR0mCPYo820hYrcKi7DAvkmhNL_TK-pW72kCxSxjEYLlOnfo-8Fg2Jz6frB-i_dnYDwdI7GL-pMutS34m4eJXc/s1275/IMG_20231227_225132.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="1275" data-original-width="1080" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiaS-K_BwSmk3G4uMVKfxP2SNMAlIubrVB554aXG7rzv0rOLe5fxTDzdHJowzmxAhRaRZaHSerr1199Sbvt-yXqOZO7-TQa1VmgnLKJgLR0mCPYo820hYrcKi7DAvkmhNL_TK-pW72kCxSxjEYLlOnfo-8Fg2Jz6frB-i_dnYDwdI7GL-pMutS34m4eJXc/s16000/IMG_20231227_225132.jpg" /></a></div><span style="font-family: Noto Sans; font-size: medium;"><br /></span><p></p><p><span style="font-family: Noto Sans; font-size: medium;">Embrace the truth that you are more than your physical disorder, disability or any health issue you may be battling. It's time to challenge the stigmas and let go of the misconceptions that may define us. We are multifaceted individuals with amazing capabilities and potentials.</span></p><p><span style="font-family: Noto Sans; font-size: medium;">Recovery is not a quick fix or a one-size-fits-all solution. It is a lifelong journey, full of ups and downs. But remember, you are not alone. Countless others are walking this path alongside you, cheering you on, and offering their support.</span></p><p><span style="font-family: Noto Sans; font-size: medium;">Let's break free from the chains that society often places upon us. Our worth does not lie solely within the confines of our physical health struggles. We are thinkers, creatives, and innovators. Our dreams and aspirations extend far beyond the limitations of our physical health.</span></p><p><span style="font-family: Noto Sans; font-size: medium;">The journey towards recovery may be challenging, and it's perfectly normal to have setbacks. But take heart, for it is through these challenges that we grow stronger and gain valuable lessons. Each step forward, no matter how small, is a triumph to be celebrated.</span></p><p><span style="font-family: Noto Sans; font-size: medium;">Let's defy society's expectations and debunk the misconceptions. Don't let anyone tell you that your dreams are unattainable because of your physical health. Seize every opportunity, nurture your passions, and work tirelessly towards your aspirations.</span></p><p><span style="font-family: Noto Sans; font-size: medium;">Remember, you are a human being with infinite worth. Your physical health issue does not define you. Your strength, resilience, and determination are what truly define you as a person. Embrace your uniqueness, and show the world what you're capable of.</span></p><p><span style="font-family: Noto Sans; font-size: medium;">So, let's stop the stigmas. Let's educate ourselves and others about physical health, breaking down the barriers that prevent understanding and support. Together, we can create a world that embraces the whole person, where physical health struggles do not overshadow our bright futures.</span></p><p><span style="font-family: Noto Sans; font-size: medium;">You are more than your neurological disorder or any health issue you go through. You have hopes, dreams, and aspirations that deserve to be pursued. Let us rise above the labels and allow our true selves to shine. We are capable of achieving greatness, and together, we will create a world where mental health is understood, accepted, and embraced.</span></p><p><span style="font-family: Noto Sans; font-size: medium;">Hold your head high, my friend. Your strength is inspiring, and your journey is worth fighting for. You are not defined by your health issue; you are defined by your courage, resilience, and the beautiful soul within you. Keep going, keep believing, and keep reminding yourself that you are more than your struggles.</span></p><p><span style="font-family: Noto Sans; font-size: medium;"><br /></span></p><p><span style="font-family: Noto Sans; font-size: medium;">Your Truly</span></p><p><span style="font-family: Noto Sans; font-size: medium;"><i><b>Dr. Rohit Bhaskar (Physiotherapist)</b></i></span></p><p><span style="font-family: Noto Sans; font-size: medium;"><i>Director & Head: CARE Physiotherapy Clinic, Jhansi </i></span></p>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-2612489749301874662023-12-16T08:54:00.000-08:002023-12-16T09:22:32.797-08:00Eating a Late Breakfast and Dinner Post 9 PM Can Significantly Up Your Heart Attack Risk: Study<p><span style="font-family: Noto Sans; font-size: medium;">Eating meals earlier can reduce the risk of cardiovascular disease, according to a new <a href="https://www.nature.com/articles/s41467-023-43444-3" target="_blank">study published in the journal Nature Communications.</a></span></p><p><span style="font-family: Noto Sans; font-size: medium;">In their <a href="https://www.nature.com/articles/s41467-023-43444-3" target="_blank">study</a>, researchers looked at data from 103,389 adults with a median age of 42 who participated in the <a href="https://clinicaltrials.gov/study/NCT03335644" target="_blank">NutriNet-Santé study.</a></span></p><p><span style="font-family: Noto Sans; font-size: medium;"><br /></span></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi6BkJWODtpdGy-xQLRlkohOcwfJ3MTstFcJu86b5kFnJnaLs_rbY1R4neH0fA4JT3jn8IR6lF1bWrKtS_HbHS8jZGfrwI8iivr6Ln5r7J45ShiWWMLudeJXztL5k0ImyinO7eUrP1c5AyImKxXV5XMsccIDBRwDwOaOsU3PzSSn7Bb2WQ_5xfdAro7lAk/s678/images%20(25).jpeg" style="margin-left: 1em; margin-right: 1em;"><span style="font-family: Noto Sans; font-size: medium;"><img border="0" data-original-height="452" data-original-width="678" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi6BkJWODtpdGy-xQLRlkohOcwfJ3MTstFcJu86b5kFnJnaLs_rbY1R4neH0fA4JT3jn8IR6lF1bWrKtS_HbHS8jZGfrwI8iivr6Ln5r7J45ShiWWMLudeJXztL5k0ImyinO7eUrP1c5AyImKxXV5XMsccIDBRwDwOaOsU3PzSSn7Bb2WQ_5xfdAro7lAk/s16000/images%20(25).jpeg" /></span></a></div><p><span style="font-family: Noto Sans; font-size: medium;"><br /></span></p><p style="-webkit-font-smoothing: antialiased; box-sizing: inherit; line-height: 26px; margin-bottom: 20px; margin-top: 20px;"><span style="font-family: Noto Sans; font-size: medium;">The researchers observed the following findings associated with meal timings between 8 a.m. and 9 p.m.:</span></p><ul style="-webkit-font-smoothing: antialiased; box-sizing: inherit; list-style-image: url("data:image/svg+xml,%3Csvg width='10' height='10' xmlns='http://www.w3.org/2000/svg'%3E%3Ccircle cx='5' cy='5' r='2.5' fill='%23000'/%3E%3C/svg%3E");"><li style="-webkit-font-smoothing: antialiased; box-sizing: inherit; line-height: 26px; margin-bottom: 8px;"><span style="font-family: Noto Sans; font-size: medium;">Delaying the day’s first meal was associated with a higher risk of cardiovascular disease.</span></li><li style="-webkit-font-smoothing: antialiased; box-sizing: inherit; line-height: 26px; margin-bottom: 8px;"><span style="font-family: Noto Sans; font-size: medium;">Each additional hour of delay was associated with an 6% increase in <a class="content-link css-1pg8eb5" href="https://www.medicalnewstoday.com/articles/184601" style="-webkit-font-smoothing: antialiased; border-color: currentcolor; box-sizing: inherit; cursor: pointer; text-decoration-line: none;">cerebrovascular disease</a>.</span></li><li style="-webkit-font-smoothing: antialiased; box-sizing: inherit; line-height: 26px; margin-bottom: 8px;"><span style="font-family: Noto Sans; font-size: medium;">Eating a last meal of the day after 9 p.m. was associated with a 28% higher risk of cerebrovascular disease than those who ate before 8 p.m.</span></li><li style="-webkit-font-smoothing: antialiased; box-sizing: inherit; line-height: 26px; margin-bottom: 8px;"><span style="font-family: Noto Sans; font-size: medium;">No significant additional risk was associated with the number of times someone ate.</span></li><li style="-webkit-font-smoothing: antialiased; box-sizing: inherit; line-height: 26px; margin-bottom: 8px;"><span style="font-family: Noto Sans; font-size: medium;">Each additional hour of nighttime fasting (eating an earlier evening meal rather than delaying breakfast) was associated with a 7% lower risk of cerebrovascular disease.</span></li></ul><p style="-webkit-font-smoothing: antialiased; box-sizing: inherit; line-height: 26px; margin-bottom: 20px; margin-top: 20px;"><span style="font-family: Noto Sans; font-size: medium;">The researchers added that the differences in negative associations in the timing of the day’s last meal were more significant in women than in men.</span></p><p style="-webkit-font-smoothing: antialiased; box-sizing: inherit; line-height: 26px; margin-bottom: 20px; margin-top: 20px;"><span style="font-size: medium;"><span style="font-family: Noto Sans;">“Circadian rhythms are cyclic endogenous (built-in) biological patterns that follow a 24-hour cycle that regulates the timing of physiology, metabolism, and behavior,”</span><span style="font-family: "Noto Sans";">. </span></span></p><p style="-webkit-font-smoothing: antialiased; box-sizing: inherit; line-height: 26px; margin-bottom: 20px; margin-top: 20px;"><span style="font-size: medium;"><span style="font-family: "Noto Sans";">“When your mealtimes don’t match your body clock, it may spike fat-storing hormones, causing weight gain. There’s a </span>Circadian Rhythm Diet<span style="font-family: "Noto Sans";"> based on the ideal times to eat breakfast, lunch, and dinner. </span><em style="-webkit-font-smoothing: antialiased; box-sizing: inherit; font-family: "Noto Sans";"></em><span style="font-family: "Noto Sans";">That being said, I think that timing of eating should be considered in relation to our overall health.”</span></span></p><p><span style="font-family: Noto Sans; font-size: medium;"><b>References:</b> Palomar-Cros, A., Andreeva, V.A., Fezeu, L.K. et al. Dietary circadian rhythms and cardiovascular disease risk in the prospective NutriNet-Santé cohort. Nat Commun 14, 7899 (2023). https://doi.org/10.1038/s41467-023-43444-3</span></p>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-75386977451186616162023-10-16T10:46:00.008-07:002023-10-16T12:00:05.477-07:00Important Myths and Facts About Spinal Health<p><span style="background-color: white;"><span style="font-family: Public Sans; font-size: medium;">The spine is the body's backbone and the main structural support for movements including sitting, standing, walking, twisting, and bending. The effectiveness of a person's daily activities and lifestyle are determined by their spine's health since deformities or disorders in the spine can cause excruciating back pain and other problems that can negatively impact a person's quality of life.</span></span></p><p><span style="background-color: white;"></span></p><div class="separator" style="clear: both; text-align: center;"><span style="background-color: white;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi9D1U4yI4BDMSQBqaVZQD1NEJbdtNSTw4wwK7hH9Lnk-bh7ArylEQ__g2ED9HkNGt7sfI8p26gkcPUxK3cEs2cQajS5i9s1Hd9Zn3whAI9D8abghJVjIXf3Y9ACtlTq_Byc18jwVLxO9WZOIdLD9GT7PysBc5T1G_7kckmEp_1sLhwM3Z4ruFhp7iGeus/s900/Causes-and-Risks-of-Spinal-Cord-Injuries.jpeg" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="600" data-original-width="900" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi9D1U4yI4BDMSQBqaVZQD1NEJbdtNSTw4wwK7hH9Lnk-bh7ArylEQ__g2ED9HkNGt7sfI8p26gkcPUxK3cEs2cQajS5i9s1Hd9Zn3whAI9D8abghJVjIXf3Y9ACtlTq_Byc18jwVLxO9WZOIdLD9GT7PysBc5T1G_7kckmEp_1sLhwM3Z4ruFhp7iGeus/s16000/Causes-and-Risks-of-Spinal-Cord-Injuries.jpeg" /></a></span></div><span style="background-color: white;"><span style="font-family: Public Sans; font-size: medium;"><br /></span></span><p></p><h2 style="text-align: left;"><span style="font-family: Rowdies; font-size: large;"><span style="background-color: white; font-weight: normal;">7 Important Myths and Facts About Spinal Health</span></span></h2><p><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: white;">Understanding the truth about spinal health is vital to your wellbeing as there are many myths and misconceptions about healthcare that can mislead people.</span></span></p><p><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: white;"><br /></span></span></p><h2 style="text-align: left;"><span style="font-family: Rowdies; font-size: large;"><span style="background-color: white; font-weight: normal;">1. Myth: Good posture is all about sitting up straight</span></span></h2><p><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: white;"><b>Fact:</b> Good posture is not just about sitting up straight. It is all about maintaining the spine's natural curves while sitting or standing. It's not about being rigidly straight.</span></span></p><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Public Sans; font-size: medium;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhPbAL9lpmp43zELpx1ti5B-sWhU5K4zHbjheQlaj6aKpHoNxpuP_OKRJIRDXFu2rhtGT5XY9U7js6ETDkkn9wbKZ7p78Tiim63OU4OGYFhRFYJiVGG5c6PedWNK6wzocZyrcVoB8z8_IEJMWWYo6-dZ8KEN6TG1nVevRZru_jo1yTfrnkTe7rgPXlkAgs/s1920/55453810_l.jpg" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="1273" data-original-width="1920" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhPbAL9lpmp43zELpx1ti5B-sWhU5K4zHbjheQlaj6aKpHoNxpuP_OKRJIRDXFu2rhtGT5XY9U7js6ETDkkn9wbKZ7p78Tiim63OU4OGYFhRFYJiVGG5c6PedWNK6wzocZyrcVoB8z8_IEJMWWYo6-dZ8KEN6TG1nVevRZru_jo1yTfrnkTe7rgPXlkAgs/s16000/55453810_l.jpg" /></a></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Public Sans; font-size: medium;"><br /></span></div><p></p><h3 style="text-align: left;"><span style="font-family: Rowdies; font-size: large;"><span style="background-color: white; font-weight: normal;">2. Myth: Back pain is a natural part of aging</span></span></h3><p><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: white;"><b>Fact:</b> Back pain indeed gets common as people age, but chronic back pain is not an inevitable phenomenon. It can often be prevented or managed with proper care. Maintaining a healthy weight, being physically active and maintaining good posture helps in preventing back pain.</span></span></p><p><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: white;"><br /></span></span></p><h3 style="text-align: left;"><span style="font-family: Rowdies; font-size: large;"><span style="background-color: white; font-weight: normal;">3. Myth: Lifting heavy objects is the only way you can get your back injured</span></span></h3><p><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: white;"><b>Fact:</b> Lifting heavy objects is not the only way to get your back injured. Everyday activities like poor posture, prolonged sitting, or even sudden twisting physical motions can strain the back and result in injuries.</span></span></p><p><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: white;"><br /></span></span></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi7k32t1bqc0JmRr8lAc7vXZZWcAQ1QMh0fJekUMK-szQT8-n1w_wUptp1KLVAqdUhZTm0oCgTyeRtzlyf2uXUpJx8JnwKoNHsEGEd6dH-NL7gvuDribP2tCbsBci-YubPdRk8O5XolM0pu-tohJ7Oy4ND-COH368anvMZSZd_g8aFsUhIRDt7gN6Gh0e0/s1920/caution-heavy-object-use-lifting-aids-label-on-white-background-free-vector.jpg" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="1920" data-original-width="1371" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi7k32t1bqc0JmRr8lAc7vXZZWcAQ1QMh0fJekUMK-szQT8-n1w_wUptp1KLVAqdUhZTm0oCgTyeRtzlyf2uXUpJx8JnwKoNHsEGEd6dH-NL7gvuDribP2tCbsBci-YubPdRk8O5XolM0pu-tohJ7Oy4ND-COH368anvMZSZd_g8aFsUhIRDt7gN6Gh0e0/s16000/caution-heavy-object-use-lifting-aids-label-on-white-background-free-vector.jpg" /></a></div><div class="separator" style="clear: both; text-align: center;"><br /></div><h3 style="text-align: left;"><span style="font-family: Rowdies; font-size: large;"><span style="background-color: white; font-weight: normal;">4. Myth: Rest is the best way to heal a back injury</span></span></h3><p><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: white;">Fact: Resting can surely help with back pain but it's not the best and only way. In fact, in some cases, resting too much can slow down recovery. Gentle movements and exercises may help in speeding up the healing process.</span></span></p><p><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: white;"><br /></span></span></p><h3 style="text-align: left;"><span style="font-family: Rowdies; font-size: large;"><span style="background-color: white; font-weight: normal;">5. Myth: Exercise is harmful for people with back pain</span></span></h3><p><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: white;"><b>Fact: </b>While rigorous exercises may be harmful as they cause strain on back, light exercises might actually be helpful in alleviating the back pain. If done correctly, exercising can strengthen the back and eliminate the pain. It's also better to consult with a healthcare professional for the right guidance regarding exercises.</span></span></p><p><span style="font-family: Public Sans; font-size: medium;"></span></p><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Public Sans; font-size: medium;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhYtJp-48Yfote2-jOHgxwWIYb9jdNB0N9a8QNDfE4uTCkpVAZ38W0vaS8K-ZL-CDpqiqKw9FTCsSTsHhPs6SmD_qiUaa7BBLt8OoSyKCQvbs2kswKDUkiV8FvqRvl0CbnV8og3r89TDyhuoihGIrytWuVYQ9ZPma-4GSdd_B_GMIkf68NHrOadd9o5R3Y/s590/Fitness-Big-three-stretches-after-workout-ease-back-pain-in-a-matter-of-minutes-1573194.jpg" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="350" data-original-width="590" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhYtJp-48Yfote2-jOHgxwWIYb9jdNB0N9a8QNDfE4uTCkpVAZ38W0vaS8K-ZL-CDpqiqKw9FTCsSTsHhPs6SmD_qiUaa7BBLt8OoSyKCQvbs2kswKDUkiV8FvqRvl0CbnV8og3r89TDyhuoihGIrytWuVYQ9ZPma-4GSdd_B_GMIkf68NHrOadd9o5R3Y/s16000/Fitness-Big-three-stretches-after-workout-ease-back-pain-in-a-matter-of-minutes-1573194.jpg" /></a></span></div><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: white;"><br /></span></span><p></p><h3 style="text-align: left;"><span style="font-family: Rowdies; font-size: large;"><span style="background-color: white; font-weight: normal;">6. Myth: Surgery is the only solution for excruciating back pain</span></span></h3><p><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: white;"><b>Fact:</b> This is not entirely true. Surgery is often a last resort. There are a plethora of ways through which excruciating back pain can be eradicated. Many spinal issues can be managed through non- invasive treatments like physical therapy and lifestyle changes. Surgery is performed when the other methods of treatment are not making any difference on the back pain.</span></span></p><p><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: white;"><br /></span></span></p><p><span style="font-family: Public Sans; font-size: medium;"></span></p><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Public Sans; font-size: medium;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgidty8ADvzEh79KHT-42YnqG5WbZNzPRI9AE21vlsIoJm6XW6ggGGjrZ5s2EoLCtjvbI8kZZ4zFRpbpSp49hvV8sL703Vf92O_kKGaBN_F7eDw87vUrR-A42SzdesXHIWHJB7F4dWkKAYDttv5h95oqQ9_LFlYC3XIkjSG_UEM7fs0qdSU2dLUU324nVw/s870/images%20(13).jpeg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="353" data-original-width="870" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgidty8ADvzEh79KHT-42YnqG5WbZNzPRI9AE21vlsIoJm6XW6ggGGjrZ5s2EoLCtjvbI8kZZ4zFRpbpSp49hvV8sL703Vf92O_kKGaBN_F7eDw87vUrR-A42SzdesXHIWHJB7F4dWkKAYDttv5h95oqQ9_LFlYC3XIkjSG_UEM7fs0qdSU2dLUU324nVw/s16000/images%20(13).jpeg" /></a></span></div><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: white;"><br /></span></span><p></p><h3 style="text-align: left;"><span style="font-family: Rowdies; font-size: large;"><span style="background-color: white; font-weight: normal;">7. Myth: Once you have back pain, it won't go. It will be there lifelong</span></span></h3><p><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: white;"><b>Fact:</b> Back pains don't always last for a lifetime. Most of the time, back pain is temporary and can get better with proper care. Lifestyle changes and treatment also significantly help in alleviating the back pain.</span></span></p><p><span style="font-family: Public Sans; font-size: medium;"></span></p><div class="separator" style="clear: both; text-align: center;"><br /></div><p><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: white;">Understanding the truths behind spinal health myths is important for maintaining a healthy back. Focus on proactive measures and seek professional guidance when needed.</span></span></p>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-6484108001462721272023-09-25T19:42:00.013-07:002023-09-25T19:59:07.717-07:00Reversing Paralysis Through Spinal Cord Regeneration: Study <div><span style="font-family: Rubik; font-size: medium;">Scientists at .<b>NeuroRestore</b>, Switzerland, report in Science that they have developed a gene therapy that was proven in mice to stimulate nerve regrowth across spinal cord injuries and guide nerves to reconnect to their natural targets to restore mobility.</span></div><div><span style="font-family: Rubik; font-size: medium;"><br /></span></div><div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj9jigk66mGgH2BWYCaRuwnxqYPuMBXcGRa_AOC70myXtGRR8vkgGZlTDTmn2o39NUDehFROP8ta99r3fvZMSvKbbKyaZgrZnVlSHkPJUQDKoBzN7UMQCNReCdqVE672rCadvqLFo3SFKxUO7yji_kuOsRLoOvrJPsBjeNKsHfNSlUam3rX6IHfpTxnYiE/s662/images%20(12).jpeg" style="margin-left: 1em; margin-right: 1em;"><span style="color: black;"><img border="0" data-original-height="463" data-original-width="662" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj9jigk66mGgH2BWYCaRuwnxqYPuMBXcGRa_AOC70myXtGRR8vkgGZlTDTmn2o39NUDehFROP8ta99r3fvZMSvKbbKyaZgrZnVlSHkPJUQDKoBzN7UMQCNReCdqVE672rCadvqLFo3SFKxUO7yji_kuOsRLoOvrJPsBjeNKsHfNSlUam3rX6IHfpTxnYiE/s16000/images%20(12).jpeg" /></span></a></div></div><div><span style="font-family: Rubik; font-size: medium;"><br /></span></div><div><span style="font-family: Rubik; font-size: medium;">When the spinal cords of mice and humans are partially damaged, the initial paralysis is followed by the extensive, spontaneous recovery of motor function. However, after a complete spinal cord injury, this natural repair of the spinal cord doesn’t occur and there is no recovery. </span></div><div><span style="font-family: Rubik; font-size: medium;"><br /></span></div><div><span style="font-family: Rubik; font-size: medium;">Meaningful recovery after severe injuries requires strategies that promote the regeneration of nerve fibers, but the requisite conditions for these strategies to successfully restore motor function have remained elusive.</span></div><div><span style="font-family: Rubik; font-size: medium;"><br /></span></div><div><span style="font-family: Rubik; font-size: medium;"><b>Previous Discoveries and Recent Developments</b></span></div><div><span style="font-family: Rubik; font-size: medium;">“Five years ago, we demonstrated that nerve fibers can be regenerated across anatomically complete spinal cord injuries,” says Mark Anderson, a senior author of the study. “But we also realized this wasn’t enough to restore motor function, as the new fibers failed to connect to the right places on the other side of the lesion.” Anderson is the director of Central Nervous System Regeneration at .NeuroRestore and a scientist at the Wyss Center for Bio and Neuroengineering.</span></div><div><span style="font-family: Rubik; font-size: medium;"><br /></span></div><div><span style="font-family: Rubik; font-size: medium;">Working in tandem with peers at University of California, Los Angeles (UCLA) and Harvard Medical School, the scientists used state-of-the-art equipment at EPFL’s Campus Biotech facilities in Geneva to run in-depth analyses and identify which type of neuron is involved in natural spinal cord repair after partial spinal cord injury. “Our observations using single-cell nuclear RNA sequencing not only exposed the specific axons that must regenerate, but also revealed that these axons must reconnect to their natural targets to restore motor function,” says Jordan Squair, the study’s first author. The team’s findings appear in the September 22, 2023, issue of Science.</span></div><div><span style="font-family: Rubik; font-size: medium;"><br /></span></div><div><span style="font-family: Rubik; font-size: medium;">Mice with anatomically complete spinal cord injuries regained the ability to walk, exhibiting gait patterns that resembled those quantified in mice that resumed walking naturally after partial injuries. This observation revealed a previously unknown condition for regenerative therapies to be successful in restoring motor function after neurotrauma. </span></div><div><span style="font-family: Rubik; font-size: medium;"><br /></span></div><div><span style="font-family: Rubik; font-size: medium;">“We expect that our gene therapy will act synergistically with our other procedures involving electrical stimulation of the spinal cord,” says Grégoire Courtine, a senior author of the study who also heads .NeuroRestore together with Jocelyne Bloch. “We believe a complete solution for treating spinal cord injury will require both approaches – gene therapy to regrow relevant nerve fibers, and spinal stimulation to maximize the ability of both these fibers and the spinal cord below the injury to produce movement.”</span></div><div><span style="font-family: Rubik; font-size: medium;"><br /></span></div><div><span style="font-family: Rubik; font-size: medium;">While many obstacles must still be overcome before this gene therapy can be applied in humans, the scientists have taken the first steps towards developing the technology necessary to achieve this feat in the years to come.</span></div><div><span style="font-family: Rubik; font-size: medium;"><br /></span></div><div><span style="font-family: Rubik; font-size: medium;"><br /></span></div><div><span style="font-family: Rubik; font-size: medium;"><b>Reference</b>: “Recovery of walking after paralysis by regenerating characterized neurons to their natural target region” by Jordan W. Squair, Marco Milano, Alexandra de Coucy, Matthieu Gautier, Michael A. Skinnider, Nicholas D. James, Newton Cho, Anna Lasne, Claudia Kathe, Thomas H. Hutson Steven Ceto, Laetitia Baud, Katia Galan, Viviana Aureli, Achilleas Laskaratos, Quentin Barraud Timothy J. Deming, Richie E. Kohman, Bernard L. Schneider, Zhigang He, Jocelyne Bloch, Michael V. Sofroniew, Gregoire Courtine and Mark A. Anderson, 21 September 2023, Science.</span><span> </span><span style="font-family: Rubik; font-size: large;"><a href="https://www.science.org/doi/10.1126/science.adi6412" target="_blank">DOI: 10.1126/science.adi6412</a></span></div>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-60909934345644272492023-09-12T11:01:00.004-07:002023-09-12T11:12:52.762-07:00Night Owls Beware: Staying Up Late Tied to Increased Diabetes Risk<p><span style="font-family: Public Sans;"><span style="background-color: white; font-size: 17.008px;">A new study has an important message for people who consider themselves night owls. Investigators from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, found that people with later sleep and wake times had less healthy lifestyles and were at greater risk of developing diabetes than those with early-bird sleep habits. Their results were published on September 12 in the </span><em style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Annals of Internal Medicine</em><span style="background-color: white; font-size: 17.008px;">.</span></span></p><p><span style="font-family: Public Sans;"><span style="background-color: white; font-size: 17.008px;"><br /></span></span></p><p><span style="font-family: Public Sans;"></span></p><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Public Sans;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAhFiEHkf87i-8817V27A978aaigR_uap9JgKe8_ELZMBh-Wh_DF93I3h19GRwN9K1ld9kvckVpeSZcEQYH7L5E9HUIujplVNVXItHa70-ogI4RTy327cRTh_mlJliaSuedGqFUD2gZQ4Y6C1CCJHGLzCwsWb7GMkQuy5uQTbzP-klaOLRXhuByt1ivpo/s800/THUMBNAIL_shutterstock_1034059600.jpg" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="450" data-original-width="800" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAhFiEHkf87i-8817V27A978aaigR_uap9JgKe8_ELZMBh-Wh_DF93I3h19GRwN9K1ld9kvckVpeSZcEQYH7L5E9HUIujplVNVXItHa70-ogI4RTy327cRTh_mlJliaSuedGqFUD2gZQ4Y6C1CCJHGLzCwsWb7GMkQuy5uQTbzP-klaOLRXhuByt1ivpo/s16000/THUMBNAIL_shutterstock_1034059600.jpg" /></a></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Public Sans;"><br /></span></div><p></p><span data-ez-ph-id="110" style="background-color: white; border: 0px; display: block; float: none; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: 0; margin: 15px auto; padding: 0px; text-align: center; vertical-align: baseline;"><span class="ezoic-ad ezoic-at-0 medrectangle-3 medrectangle-3110 adtester-container adtester-container-110" data-ez-name="scitechdaily_com-medrectangle-3" style="border: 0px; display: block; float: none; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: 0px; margin: 15px auto; padding: 0px; vertical-align: baseline;"><span class="ezoic-ad ezfound" ezah="90" ezaw="728" id="div-gpt-ad-scitechdaily_com-medrectangle-3-0" style="border: 0px; display: inline-block; font-family: Public Sans; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; min-height: 0px; min-width: 0px; padding: 0px; position: relative; vertical-align: baseline; width: 726.577px; z-index: 0;"><div class="apscustom" data-aps-custom-status="read" id="93b7dd52-a8ce-11ed-afa1-0242ac120002:1" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></div></span></span></span><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">“Chronotype, or circadian preference, refers to a person’s preferred timing of sleep and waking and is partly genetically determined so it may be difficult to change,” said corresponding author Tianyi Huang, MSc, ScD, an associate epidemiologist in the Brigham’s Channing Division of Network Medicine. “People who think they are ‘night owls’ may need to pay more attention to their lifestyle because their evening chronotype may add increased risk for type 2 diabetes.”</span></p><div id="ezwrap_medianet_queue_0" style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><div id="974871025" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></div></div><h4 style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 1.25rem; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: 1.3; margin: 0px 0px 1.25rem; padding: 0px; transition: all 0.5s ease 0s; vertical-align: baseline;"><b><span style="color: black; font-family: Public Sans;">The Study’s Findings</span></b></h4><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;"><span class="ezoic-adpicker-ad" id="ezoic-pub-ad-placeholder-606" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span>The researchers previously found that people with more irregular sleep schedules are at higher risk of developing diabetes and <span aria-describedby="tt" class="glossaryLink" data-cmtooltip="<div class=glossaryItemTitle>cardiovascular disease</div><div class=glossaryItemBody>Cardiovascular disease refers to a group of conditions that affect the heart and blood vessels, such as coronary artery disease, heart failure, arrhythmias, and stroke. It is caused by a variety of factors, including lifestyle choices (such as smoking and poor diet), genetics, and underlying medical conditions (such as high blood pressure and diabetes). Cardiovascular disease is a leading cause of death worldwide, but can often be prevented or managed through lifestyle changes, medications, and medical procedures such as bypass surgery and angioplasty.</div>" data-gt-translate-attributes="[{"attribute":"data-cmtooltip", "format":"html"}]" style="border-bottom-color: rgb(0, 0, 0); border-bottom-style: dotted; border-image: initial; border-left-color: initial; border-left-style: initial; border-right-color: initial; border-right-style: initial; border-top-color: initial; border-top-style: initial; border-width: 0px 0px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">cardiovascular disease</span> and that people with evening chronotypes are more likely to have irregular sleep patterns. For this study, they wanted to understand the relationship between chronotype and diabetes risk and looked at the role of lifestyle factors as well.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">The team analyzed data from 63,676 female nurses from the Nurses’ Health Study II collected from 2009-2017 and included self-reported chronotype (the extent to which participants perceived themselves to be an evening person or a morning person), diet quality, weight and body mass index, sleep timing, smoking behaviors, alcohol use, physical activity, and family history of diabetes. The team determined diabetes status from the participants’ self-reports and medical records.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">The Nurses’ Health Study II, a joint effort between the Brigham’s Channing Division of Network Medicine and Harvard T.H. Chan School of Public Health, is among the largest investigations into risk factors for major chronic diseases in women. One of the study’s strengths is its regular follow-up of study participants and repeated assessment of health and lifestyle factors.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">Approximately 11 percent of participants reported having a ‘definite evening’ chronotype and about 35 percent reported having ‘definite morning’ chronotype. The remaining population, around half, were labeled as ‘intermediate,’ meaning they either identified as being neither a morning nor evening type or as being only slightly more one than the other.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">The evening chronotype was associated with a 72 percent increased risk for diabetes before accounting for lifestyle factors. After accounting for lifestyle factors, evening chronotype was associated with a 19 percent increased risk of diabetes. Among those in the study with the healthiest lifestyles, only 6 percent had evening chronotypes. Among those with the unhealthiest lifestyles 25 percent were evening chronotypes.<span class="ezoic-adpicker-ad" id="ezoic-pub-ad-placeholder-608" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">Those with evening chronotypes were found to be more likely to drink alcohol in higher quantities, have a low-quality food diet, get less hours of sleep per night, currently smoke, and have weight, BMI, and physical activity rates in the unhealthy range.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;"><br /></span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;"><b>Reference:</b> “Chronotype, Unhealthy Lifestyle, and Diabetes Risk in Middle-Aged U.S. Women: A Prospective Cohort Study” by Sina Kianersi, DVM, PhD; Yue Liu, MD; Marta Guasch-Ferré, PhD; Susan Redline, MD, MPH; Eva Schernhammer, MD, DrPH; Qi Sun, MD, ScD and Tianyi Huang, ScD, MSc, 12 september 2023, <em style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Annals of Internal Medicine.</em><br /><a href="https://doi.org/10.7326/M23-0728" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: 600; line-height: inherit; margin: 0px; padding: 0px; text-decoration-line: none; transition: all 0.5s ease 0s; vertical-align: baseline;">DOI: 10.7326/M23-0728</a></span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">Funding: This study was funded by the <span aria-describedby="tt" class="glossaryLink" data-cmtooltip="<div class=glossaryItemTitle>National Institutes of Health</div><div class=glossaryItemBody>The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. Founded in 1887, it is a part of the U.S. Department of Health and Human Services. The NIH conducts its own scientific research through its Intramural Research Program (IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program. With 27 different institutes and centers under its umbrella, the NIH covers a broad spectrum of health-related research, including specific diseases, population health, clinical research, and fundamental biological processes. Its mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability.</div>" data-gt-translate-attributes="[{"attribute":"data-cmtooltip", "format":"html"}]" style="border-bottom-color: rgb(0, 0, 0); border-bottom-style: dotted; border-image: initial; border-left-color: initial; border-left-style: initial; border-right-color: initial; border-right-style: initial; border-top-color: initial; border-top-style: initial; border-width: 0px 0px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">National Institutes of Health</span> (U01CA176726 and R01HL155395).</span></p>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-16153797030371200072023-09-12T10:57:00.004-07:002023-09-12T11:04:07.071-07:00Particulate Air Pollution Is Associated With Breast Cancer: Study<p><span style="font-family: Public Sans; font-size: medium;"><span face=""Open Sans", sans-serif">Researchers at the National Institutes of Health found that living in an area with high levels of particulate air pollution was associated with an increased incidence of breast cancer. The study, published in the </span><em>Journal of the National Cancer Institute</em><span face=""Open Sans", sans-serif">, is one of the largest studies to date looking at the relationship between outdoor air pollution, specifically fine particulate matter, and breast cancer incidence. The research was done by scientists at the National Institute of Environmental Health Sciences (NIEHS) and the National Cancer Institute (NCI), both part of NIH.</span></span></p><p style="margin: 5px 0px;"><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p style="margin: 5px 0px;"></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEju8ZHvcl_BaHB_D4b7-9uzRSUcEbcuiuz3hBq-SiToEPWttJHQjUli3Ohsi0z2Nm61xbL9XHRnq46XCjuw3CPm-MaCjBfD2VH2lyln_TURoHhOAOKM9Z_QiHgXnR7NKOHPFndrJEDTmOuoprlK37n6asiE5_0uESTcCeezv0s8dFldtbnALScW5EUbX-M/s2000/ImageForNews_31751_16535771169871778.webp" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="1123" data-original-width="2000" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEju8ZHvcl_BaHB_D4b7-9uzRSUcEbcuiuz3hBq-SiToEPWttJHQjUli3Ohsi0z2Nm61xbL9XHRnq46XCjuw3CPm-MaCjBfD2VH2lyln_TURoHhOAOKM9Z_QiHgXnR7NKOHPFndrJEDTmOuoprlK37n6asiE5_0uESTcCeezv0s8dFldtbnALScW5EUbX-M/s16000/ImageForNews_31751_16535771169871778.webp" /></a></div><br /><p></p><p style="margin: 5px 0px;"><span style="font-family: Public Sans; font-size: medium;">The researchers saw that the largest increase<s>s</s> in breast cancer incidence was among women who on average had higher particulate matter levels (PM2.5) near their home prior to enrolling in the study, compared to those who lived in areas with lower levels of PM2.5. Particulate matter is a mixture of solid particles and liquid droplets found in the air. It comes from numerous sources, such as motor vehicle exhaust, combustion processes (e.g., oil, coal), wood smoke/vegetation burning, and industrial emissions. The particulate matter pollution measured in this study was 2.5 microns in diameter or smaller (PM2.5), meaning the particles are small enough to be inhaled deep into the lungs. The Environmental Protection Agency has a website known as <a href="https://www.airnow.gov/" style="background-color: white; border-bottom: none; scroll-margin-top: 112px;" target="_blank">Air Now</a> where residents can enter their zip code and get the air quality information, including PM2.5 levels, for their area.</span></p><p style="margin: 5px 0px;"><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p style="margin: 5px 0px;"><span style="font-family: Public Sans; font-size: medium;">“We observed an 8% increase in breast cancer incidence for living in areas with higher PM2.5 exposure. Although this is a relatively modest increase, these findings are significant given that air pollution is a ubiquitous exposure that impacts almost everyone,” said Alexandra White, Ph.D., lead author and head of the Environment and Cancer Epidemiology Group at NIEHS. “These findings add to a growing body of literature suggesting that air pollution is related to breast cancer.” </span></p><p style="margin: 5px 0px;"><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p style="margin: 5px 0px;"><span style="font-family: Public Sans; font-size: medium;">The study was conducted using information from the NIH-AARP Diet and Health Study, which enrolled more than 500,000 men and women between 1995-96 in six states (California, Florida, Pennsylvania, New Jersey, North Carolina, and Louisiana) and in two metropolitan areas (Atlanta and Detroit). The women in the cohort were on average about 62 years of age and most identified as being non-Hispanic white. They were followed for approximately 20 years, during which 15,870 breast cancer cases were identified.</span></p><p style="margin: 5px 0px;"><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><span style="font-family: Public Sans; font-size: medium;"><span face=""Open Sans", sans-serif">The researchers estimated annual average historical PM</span><span face=""Open Sans", sans-serif" style="scroll-margin-top: 112px;">2.5</span><span face=""Open Sans", sans-serif"> concentrations for each participant’s residence. They were particularly interested in air pollution exposures during a period of 10-15 years prior to enrollment in the study, given the length of time it takes for some cancers to develop. Most previous studies have assessed breast cancer risk in relation to air pollution around the time of study enrollment and did not consider past exposures.</span></span><p style="margin: 5px 0px;"></p><p style="margin: 5px 0px;"><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p style="margin: 5px 0px;"><span style="font-family: Public Sans; font-size: medium;">“The ability to consider historic air pollution levels is an important strength of this research,” said Rena Jones, Ph.D., senior author and principal investigator of the study at NCI. “It can take many years for breast cancer to develop and, in the past, air pollution levels tended to be higher, which may make previous exposure levels particularly relevant for cancer development.”</span></p><p style="margin: 5px 0px;"><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p style="margin: 5px 0px;"><span style="font-family: Public Sans; font-size: medium;">To consider how the relationship between air pollution and breast cancer varied by the type of tumor, the researchers evaluated estrogen receptor-positive (ER+) and -negative (ER-) tumors separately. They found that PM2.5 was associated with a higher incidence of ER+ breast cancer, but not ER-, tumors. This suggests that PM2.5 may affect breast cancer through an underlying biologic pathway of endocrine disruption. ER+ tumors are the most common tumors diagnosed among women in the United States.</span></p><p style="margin: 5px 0px;"><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p style="margin: 5px 0px;"><span style="font-family: Public Sans; font-size: medium;">The authors note that the study was limited in its ability to explore any differences in the relationship between air pollution and breast cancer across the different study areas. They suggest future work should explore how the regional differences in air pollution, including the various types of PM2.5 women that women are exposed to, could impact a woman’s risk of developing breast cancer.</span></p><p style="margin: 5px 0px;"><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p style="margin: 5px 0px;"><span style="font-family: Public Sans; font-size: medium;"><b style="scroll-margin-top: 112px;">Reference: </b><span style="scroll-margin-top: 112px;">White AJ, Fisher JA, Sweeney MR, et al. Ambient fine particulate matter and breast cancer incidence in a large prospective US cohort. </span><i>JNCI: J Nat Cancer Inst</i><span style="scroll-margin-top: 112px;">. 2023:djad170. doi: </span><a href="https://doi.org/10.1093/jnci/djad170" style="border-bottom: none; scroll-margin-top: 112px;" target="_blank"><span style="scroll-margin-top: 112px;">10.1093/jnci/djad170</span></a></span></p>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-89978415855605876242023-09-12T10:42:00.001-07:002023-09-12T10:45:15.642-07:00Mother Claims ChatGPT Found Correct Diagnosis For Her Son's Chronic Pain<p><span style="background-color: white; font-family: Public Sans; font-size: medium;">OpenAI's chatbot, ChatGPT, is still making waves worldwide and surprising people with its exceptional capabilities. Ever since its advent, people across the world have been using the bot for a variety of tasks. Now, one woman has claimed that she found the correct diagnosis for her four-year-old son's chronic pain, with the help of ChatGPT.</span></p><p style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; margin-bottom: 1.5rem; margin-top: 1.5rem;"><span style="font-family: Public Sans; font-size: medium;">As reported by <a data-component="link" data-ordinal="2" data-source="inlineLink" data-type="externalLink" href="https://www.today.com/health/mom-chatgpt-diagnosis-pain-rcna101843" rel="noopener" style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; cursor: pointer; text-decoration-line: none; transition: all 200ms linear 0ms;" target="_blank"><em style="-webkit-tap-highlight-color: transparent; box-sizing: border-box;">Today</em></a>, Courtney revealed that her four-year-old son Alex was suffering from toothache, ''gigantic meltdowns'', and was also not growing in height.</span></p><p style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; margin-bottom: 1.5rem; margin-top: 1.5rem;"></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiPAsRigI-iZXT97mhCyw1Jbfh_3CU7DN9xgGQ64rk_Qt3A_2uwxBqLY3uhSk6uwDa6U-O9_-7LnEpsJ-sB2ynPrrZv6NZnj2L6IYTterO_yBuSoGISt1wqWjfdnQvHdfMKZgHfwEwgIAQA2RArTZhXSzj8Mgw4u0UuYy7bWLk3-VbvxqNbfoobyawZfkY/s1200/chatgpt-1-1694533655.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="675" data-original-width="1200" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiPAsRigI-iZXT97mhCyw1Jbfh_3CU7DN9xgGQ64rk_Qt3A_2uwxBqLY3uhSk6uwDa6U-O9_-7LnEpsJ-sB2ynPrrZv6NZnj2L6IYTterO_yBuSoGISt1wqWjfdnQvHdfMKZgHfwEwgIAQA2RArTZhXSzj8Mgw4u0UuYy7bWLk3-VbvxqNbfoobyawZfkY/s16000/chatgpt-1-1694533655.jpg" /></a></div><span style="font-family: Public Sans; font-size: medium;"><br /></span><p></p><p style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; margin-bottom: 1.5rem; margin-top: 0px;"><span style="font-family: Public Sans; font-size: medium;">When he started chewing things, she took him to the dentist, wondering if his molars were coming in and causing pain. The dentist ''ruled everything out'' and suggested her to visit an orthodontist specializing in airway obstruction. The orthodontist found that Alex's palate was too small for his mouth and teeth, which made it tougher for him to breathe at night. He was given an expander, which only helped him briefly.</span></p><p style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; margin-bottom: 1.5rem; margin-top: 0px;"><span style="font-family: Public Sans; font-size: medium;">Courtney then noticed Alex had stopped growing taller, so they visited the pediatrician, who said that it could be a pandemic aftereffect and thereafter suggested physical therapy.</span></p><p style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; margin-bottom: 1.5rem; margin-top: 0px;"><span style="font-family: Public Sans; font-size: medium;">However, before starting physical therapy, Alex started experiencing severe headaches, and a neurologist, said he had migraines. He also saw an ear, nose, and throat specialist to see if his sleep problems were due to his sinus cavities.</span></p><p style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; margin-bottom: 1.5rem; margin-top: 0px;"><span style="font-family: Public Sans; font-size: medium;">After visiting 17 doctors, over three years, Alex's issue still had no diagnosis that explained all his symptoms. </span></p><p id="mntl-sc-block_1-0-23" style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; margin-bottom: 1.5rem; margin-top: 0px;"><span style="font-family: Public Sans; font-size: medium;">''We saw so many doctors. We ended up in the ER at one point. I kept pushing. Nobody's willing to solve the greater problem. Nobody will even give you a clue about what the diagnosis could be,'' Courtney said. </span></p><p style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; margin-bottom: 1.5rem; margin-top: 0px;"><span style="font-family: Public Sans; font-size: medium;">Frustrated, she then sought help from an unlikely source and signed up for ChatGPT, where she shared her son's symptoms and all the information from medical reports.</span></p><p id="mntl-sc-block_1-0-29" style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; margin-bottom: 1.5rem; margin-top: 0px;"><span style="font-family: Public Sans; font-size: medium;">''I went line by line of everything that was in his (MRI notes) and plugged it into ChatGPT. I put the note in there about ... how he wouldn't sit crisscross applesauce. To me, that was a huge trigger (that) a structural thing could be wrong,'' she said. </span></p><p style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; margin-bottom: 1.5rem; margin-top: 0px;"><span style="font-family: Public Sans; font-size: medium;">In response, ChatGPT suggested Alex was suffering from a rare neurological condition called tethered cord syndrome. She then found a Facebook group for families of children with tethered cord syndrome and later visited a neurosurgeon who examined Alex's MRI images and figured out the problem.</span></p><p style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; margin-bottom: 1.5rem; margin-top: 0px;"><span style="font-family: Public Sans; font-size: medium;">Alex underwent surgery to fix his tethered cord syndrome a few weeks ago and is now recovering. </span></p><p style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; margin-bottom: 1.5rem; margin-top: 0px;"><span style="font-family: Public Sans; font-size: medium;">According to the <a data-component="link" data-ordinal="1" data-source="inlineLink" data-type="externalLink" href="https://www.aans.org/en/Patients/Neurosurgical-Conditions-and-Treatments/Tethered-Spinal-Cord-Syndrome#:~:text=Tethered%20spinal%20cord%20syndrome%20is,closely%20associated%20with%20spina%20bifida." rel="noopener" style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; cursor: pointer; text-decoration-line: none; transition: all 200ms linear 0ms;" target="_blank">American Association of Neurological Surgeons</a>, tethered spinal cord syndrome is a neurologic disorder caused by tissue attachments that limit the movement of the spinal cord within the spinal column. </span></p>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-60578974349734850912023-09-12T10:33:00.003-07:002023-09-12T10:40:02.091-07:00IISc Scientists Develop New Approach To Detect, Kill Cancer Cells: Study<p><span style="font-family: Public Sans;"><span style="background-color: white; font-size: 18px;">Scientists at the Indian Institute of Science (IISc) have developed a new approach to potentially detect and kill cancer cells, especially those which form a solid tumour mass.</span></span></p><p><span style="font-family: Public Sans;"><span style="background-color: white; font-size: 18px;"><br /></span></span></p><p><span style="font-family: Public Sans;"></span></p><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Public Sans;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhNBamMTYXU-nmEg2HBnY25aXcV5BHJcmjEOPwph2pz-1wnnrffUnIhKpg0QHZHtay-TeVFUK_fiXP4nCAqTLmH-U25DeIVy9GwjU91BSDAHGjK4qn2j_Pwyp81XNsuHu1aQA28YZNYPGlbrs9UE8Yz5xawzwgsRp4z2INJHSStLKwSw3NlfHH_41hHB8k/s1280/maxresdefault.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="720" data-original-width="1280" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhNBamMTYXU-nmEg2HBnY25aXcV5BHJcmjEOPwph2pz-1wnnrffUnIhKpg0QHZHtay-TeVFUK_fiXP4nCAqTLmH-U25DeIVy9GwjU91BSDAHGjK4qn2j_Pwyp81XNsuHu1aQA28YZNYPGlbrs9UE8Yz5xawzwgsRp4z2INJHSStLKwSw3NlfHH_41hHB8k/s16000/maxresdefault.jpg" /></a></span></div><span style="font-family: Public Sans;"><span style="background-color: white; font-size: 18px;"><br /></span></span><p></p><p><span style="font-family: Public Sans;"><span style="background-color: white; font-size: 18px;">They have created hybrid nanoparticles made of gold and copper sulphide, which can kill cancer cells using heat, and enable their detection using sound waves, according to a study published in 'ACS Applied Nano Materials'.</span></span></p><p><span style="font-family: Public Sans;"><span style="background-color: white; font-size: 18px;"><br /></span></span></p><p><span style="font-family: Public Sans;"><span style="background-color: white; font-size: 18px;">Early detection and treatment are key in the battle against cancer, noted the Bengaluru-based IISc in a statement on Monday. Copper sulphide nanoparticles have previously received attention for their application in cancer diagnosis, while gold nanoparticles, which can be chemically modified to target cancer cells, have shown anti-cancer effects.</span></span></p><p><span style="font-family: Public Sans;"><span style="background-color: white; font-size: 18px;"><br /></span></span></p><p><span style="font-family: Public Sans;"><span style="background-color: white; font-size: 18px;">In the current study, the IISc team decided to combine these two into hybrid nanoparticles.</span></span></p><p><span style="font-family: Public Sans;"><span style="background-color: white; font-size: 18px;"><br /></span></span></p><p><span style="font-family: Public Sans;"><span style="background-color: white; font-size: 18px;">"These particles have photothermal, oxidative stress, and photoacoustic properties," says Jaya Prakash, Assistant Professor at the Department of Instrumentation and Applied Physics (IAP), IISc, and one of the corresponding authors of the paper. PhD students Madhavi Tripathi and Swathi Padmanabhan are co-first authors.</span></span></p><p><span style="font-family: Public Sans;"><span style="background-color: white; font-size: 18px;"><br /></span></span></p><p><span style="font-family: Public Sans;"><span style="background-color: white; font-size: 18px;">When light is shined on these hybrid nanoparticles, they absorb the light and generate heat, which can kill cancer cells. These nanoparticles also produce singlet oxygen atoms that are toxic for the cells, the release pointed out. "We want both these mechanisms to kill the cancer cell," Jaya Prakash explains.</span></span></p><p><span style="font-family: Public Sans;"><span style="background-color: white; font-size: 18px;"><br /></span></span></p><p><span style="font-family: Public Sans;"><span style="background-color: white; font-size: 18px;">The researchers say the nanoparticles can also help diagnose certain cancers.</span></span></p><p><span style="font-family: Public Sans;"><span style="background-color: white; font-size: 18px;"><br /></span></span></p><p><span style="font-family: Public Sans;"><span style="background-color: white; font-size: 18px;">Existing methods such as standalone CT and MRI scans require trained radiology professionals to decipher the images. The photoacoustic property of the nanoparticles allows them to absorb light and generate ultrasound waves, which can be used to detect cancer cells with high contrast once the particles reach them.</span></span></p><p><br /></p><p><span style="font-family: Public Sans;"><span style="background-color: white; font-size: 18px;">In the current study, the researchers have tested their nanoparticles on lung cancer and cervical cancer cell lines in the lab. They now plan to take the results forward for clinical development.</span></span></p>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-37259392115726825972023-06-30T00:35:00.004-07:002023-06-30T00:44:03.638-07:00New TB Vaccine Could Save 8.5 Million Lives: What We Know<p style="background-repeat: no-repeat; box-sizing: inherit; font-variation-settings: "wght" 300, "opsz" 9; line-height: 1.55; margin: 0px 0px 16px; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans; font-size: medium;">A “game-changing” tuberculosis (TB) vaccine has reached phase three trials and could save 8.5 million lives over 25 years if proven effective. </span></p><p style="background-repeat: no-repeat; box-sizing: inherit; font-variation-settings: "wght" 300, "opsz" 9; line-height: 1.55; margin: 0px 0px 16px; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans; font-size: medium;">TB remains one of the world’s most deadly diseases, and the second leading infectious killer after Covid-19. In 2021, it led to 1.6 million deaths and affected 10.6 million people worldwide. </span></p><p style="background-repeat: no-repeat; box-sizing: inherit; font-variation-settings: "wght" 300, "opsz" 9; line-height: 1.55; margin: 0px 0px 16px; padding: 0px; vertical-align: baseline;"></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiUI7BtxGyP4xECgchAfpo72LsY3jYHoQd54etB5Yw2Q9WFCbEYVSOJLX3EYkpmWUQXaqGpwxWRgCQ-ISOIC1AZSkLIkduyDlvkOPWoLJ2lStBbexrKkiFt29p_VLXsiWkpex-STWuYPz5ZuLbMEOesH90cbKQJGlSdIhPGwAV_qwiZYx-K_9Wm5urXkyM/s1200/thequint_2023-03_2ba52955-b1d1-44e2-a5c2-886e47ecb270_iStock_1372532080.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="675" data-original-width="1200" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiUI7BtxGyP4xECgchAfpo72LsY3jYHoQd54etB5Yw2Q9WFCbEYVSOJLX3EYkpmWUQXaqGpwxWRgCQ-ISOIC1AZSkLIkduyDlvkOPWoLJ2lStBbexrKkiFt29p_VLXsiWkpex-STWuYPz5ZuLbMEOesH90cbKQJGlSdIhPGwAV_qwiZYx-K_9Wm5urXkyM/s16000/thequint_2023-03_2ba52955-b1d1-44e2-a5c2-886e47ecb270_iStock_1372532080.png" /></a></div><span style="font-family: Public Sans; font-size: medium;"><br /></span><p></p><p style="background-repeat: no-repeat; box-sizing: inherit; font-variation-settings: "wght" 300, "opsz" 9; line-height: 1.55; margin: 0px 0px 16px; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans; font-size: medium;">However, there have been no new vaccines for the disease in more than 100 years.</span></p><p style="background-repeat: no-repeat; box-sizing: inherit; font-variation-settings: "wght" 300, "opsz" 9; line-height: 1.55; margin: 0px 0px 16px; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans; font-size: medium;">The Baccilus Calmette-Guérin (BCG) vaccine was introduced in 1921 and while it helps protect babies and young children against severe systemic forms of TB, it offers limited protection among adolescents and adults.</span></p><p style="background-repeat: no-repeat; box-sizing: inherit; font-variation-settings: "wght" 300, "opsz" 9; line-height: 1.55; margin: 0px 0px 16px; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans; font-size: medium;">The new M72 vaccine is aimed at preventing latent infections in adults and adolescents from developing into full-blown illness. Latent TB is when a person is infected with the bacterium that causes TB but does not have any symptoms. Up to a quarter of the world’s population is thought to have latent TB.</span></p><p style="background-repeat: no-repeat; box-sizing: inherit; font-variation-settings: "wght" 300, "opsz" 9; line-height: 1.55; margin: 0px 0px 16px; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans; font-size: medium;">Earlier trials of M72 have shown approximately 50 per cent efficacy in reducing pulmonary TB in adults with latent infections — considered an unprecedented result in decades of research.</span></p><div class="advert-container dynamicMpu" data-ad-slot-hidden="false" data-ad-slot-id="advert_tmg_dyn_0_container" data-adtype="dyn_0" data-js="dynamicMpu-ad" data-perf="commerical-perf-0" id="advert_tmg_dyn_0_container" style="background-repeat: no-repeat; box-sizing: inherit; height: 0px; margin: 0px; padding: 0px; vertical-align: baseline;"><div class="new_premium_ads_text dynMpuAdTitle" data-test="advert-label" id="advert_tmg_dyn_0_title" style="background-color: #eeeeee; background-repeat: no-repeat; box-sizing: inherit; height: 0px; margin: 0px; padding: 0px; text-align: center; vertical-align: baseline;"></div><div class="advert js-advert" data-adtype="dyn" data-test="advert" id="advert_tmg_dyn_0" style="background-color: whitesmoke; background-repeat: no-repeat; box-sizing: inherit; height: 0px; margin: 0px; opacity: 0; overflow: hidden; padding: 0px; text-align: center; transition: opacity 0.75s ease-in-out 0s, height 1s ease 0s; vertical-align: baseline; width: 618.5px;"></div></div><p style="background-repeat: no-repeat; box-sizing: inherit; font-variation-settings: "wght" 300, "opsz" 9; line-height: 1.55; margin: 0px 0px 16px; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans; font-size: medium;">Over 25 years, a vaccine with at least 50 per cent efficacy could prevent up to 76 million new TB cases and 8.5 million deaths, and avert the need for 42 million courses of antibiotic treatment, according to the World Health Organization.</span></p><p style="background-repeat: no-repeat; box-sizing: inherit; font-variation-settings: "wght" 300, "opsz" 9; line-height: 1.55; margin: 0px 0px 16px; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans; font-size: medium;">“The tuberculosis crisis demands a new vaccine to reduce disease transmission and avoidable death, especially targeting adults and adolescents who carry at least 90 per cent of the TB epidemic’s burden,” said Dr Tedros Adhanom Ghebreyesus, the WHO’s director general.</span></p>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-14972988500576776002023-06-30T00:33:00.005-07:002023-06-30T00:45:04.267-07:00Study Identifies Potential New Treatment For Patients With Liver Disease<p><span style="background-color: white; font-family: Public Sans; font-size: 18px;">US researchers have led a study to examine a potential new treatment option for patients with nonalcoholic steatohepatitis (NASH)-related fibrosis. The results describe a drug, called Pegozafermin that mimics a hormone in the body and improves both liver fibrosis, and scarring of the liver, and liver inflammation in patients with NASH.</span></p><p></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhKP5BEPV1-BZYJs5nFMaJsv2zdkB7jakqa1VtINqaPVBh_92XKBeWwHImZ_4Whg67me7nU5ms2vhwZbhhCwVQn4fFjBwFFzzredkThxBiERu_4lTkJ_xIDIKGRcrAc1eMlFg8bv13lUb_RtRoKMkN9_bo1P207dFboE2RLKllEl-W_qjt7JypverM5aec/s1200/Liver-Failure-FB.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="630" data-original-width="1200" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhKP5BEPV1-BZYJs5nFMaJsv2zdkB7jakqa1VtINqaPVBh_92XKBeWwHImZ_4Whg67me7nU5ms2vhwZbhhCwVQn4fFjBwFFzzredkThxBiERu_4lTkJ_xIDIKGRcrAc1eMlFg8bv13lUb_RtRoKMkN9_bo1P207dFboE2RLKllEl-W_qjt7JypverM5aec/s16000/Liver-Failure-FB.jpg" /></a></div><span style="background-color: white; font-family: Public Sans; font-size: 18px;"><br /></span><p></p><span style="font-family: Public Sans;"><span face=""Open Sans", sans-serif" style="background-color: white; font-size: 18px;">Identifying this drug for NASH is extremely promising for patients as currently there are no FDA-approved therapies for the condition. NASH can adversely impact the quality of life in patients and can progress to cirrhosis. Its complications can lead to death or liver transplantation.” Our findings will further the science of this disease and provide a potential new treatment option to those affected by NASH-related fibrosis,” an expert said.<br /></span><br style="background-color: white; box-sizing: border-box; font-size: 18px;" /><span face=""Open Sans", sans-serif" style="background-color: white; font-size: 18px;">The researchers said Pegozafermin mimicked fibroblast growth factor 21 (FGF21) — a liver-secreted peptide hormone that is naturally produced in the body. FGF21 controls energy use in the body and lipid metabolism in the liver. It has also been shown in previous studies to lower blood glucose and insulin levels, reducing body weight and liver fat.</span></span><div><span style="font-family: Public Sans;"><br style="background-color: white; box-sizing: border-box; font-size: 18px;" /><span face=""Open Sans", sans-serif" style="background-color: white; font-size: 18px;">The study’s results show that the new potential treatment not only improves fibrosis but also improves inflammation and liver injury along with significant improvements across multiple non-invasive biomarkers of NASH activity and scarring.</span></span><div><span style="font-family: Public Sans;"><br style="background-color: white; box-sizing: border-box; font-size: 18px;" /><span face=""Open Sans", sans-serif" style="background-color: white; font-size: 18px;">The 24-week, randomised clinical trial involved 222 participants with NASH assigned to either receive the drug or a placebo. Of the patients who received the drug at a higher dose, approximately 27 per cent showed an improvement in liver fibrosis, relative to 7 per cent of the patients who received the placebo. The most frequently reported side effects from the drug were gastrointestinal in nature, including nausea.</span></span><div><span style="font-family: Public Sans;"><br style="background-color: white; box-sizing: border-box; font-size: 18px;" /><span face=""Open Sans", sans-serif" style="background-color: white; font-size: 18px;">The next steps for this research will be a larger, multi-center, international trial with a more diverse patient population and longer treatment period to better assess the safety of the drug.</span><br style="background-color: white; box-sizing: border-box; font-size: 18px;" /><span face=""Open Sans", sans-serif" style="background-color: white; font-size: 18px;">“If successfully shown to be both safe and effective in a larger Phase 3 trial, this drug could be used to treat millions of patients with NASH,” the researcher noted. IANS</span></span></div></div></div>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-81459986109586550962023-06-30T00:29:00.010-07:002023-07-03T20:16:42.268-07:00BMI is No Longer the Most Accurate Indicator of Obesity<h2 style="background-color: white; box-sizing: inherit; font-weight: normal; margin: 15px 0px;"><span style="font-family: Public Sans; font-size: medium;"><span>On June 14, the American Medical Association adopted a new policy, calling on doctors to <a class="link-external" href="https://www.ama-assn.org/delivering-care/public-health/ama-use-bmi-alone-imperfect-clinical-measure" rel="nofollow noopener" style="background-color: transparent; box-sizing: inherit;" target="_blank">deemphasise the role of body mass index</a>, or BMI, in clinical practice. </span><span>The statement by the American Medical Association, the </span><a class="link-external" href="https://www.ama-assn.org/about#:" rel="nofollow noopener" style="background-color: transparent; box-sizing: inherit;" target="_blank">nation’s largest association</a><span> representing physicians, signals a significant shift in how clinicians regard BMI as a measure of general health. With </span><a class="link-external" href="https://www.cdc.gov/nchs/data/databriefs/db360-h.pdf#:" rel="nofollow noopener" style="background-color: transparent; box-sizing: inherit;" target="_blank">over 40% of Americans</a><span> having obesity as defined by BMI, a movement away from BMI could have broad implications for patient care.</span></span></h2><div><span style="font-family: Public Sans; font-size: medium;"><span><br /></span></span></div><div><span style="font-family: Public Sans; font-size: medium;"><span>Body mass index (BMI) is easy to measure and inexpensive. It also has standardized cutoff points for overweight and obesity and is strongly correlated with body fat levels as measured by the most accurate methods. But BMI is an imperfect measure because it does not directly assess body fat.</span></span></div><div><span style="font-family: Public Sans; font-size: medium;"><span><br /></span></span></div><div><span style="font-family: Public Sans; font-size: medium;"><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiRIMUXDMV0CglrJP1B_qvEPOi4p9YW2vz0Suh9_FIrYhq9sFmDaDX2AsMAFCE0pHp_Am6dQD0Lf60XdPB-4V_Pgo4YumdaciVc5-y2fKXlvanT7lm3T0Wc24GInyrAaiYlrfVWkhyN-Lx6qhQ_FiicjGJpLKR1Dv7tO7jInDxalMKWk_HCrT7Y8zTfyGY/s600/bmi-adult-fb-600x315.jpg" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="315" data-original-width="600" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiRIMUXDMV0CglrJP1B_qvEPOi4p9YW2vz0Suh9_FIrYhq9sFmDaDX2AsMAFCE0pHp_Am6dQD0Lf60XdPB-4V_Pgo4YumdaciVc5-y2fKXlvanT7lm3T0Wc24GInyrAaiYlrfVWkhyN-Lx6qhQ_FiicjGJpLKR1Dv7tO7jInDxalMKWk_HCrT7Y8zTfyGY/s16000/bmi-adult-fb-600x315.jpg" /></a></div><span><br /></span></span></div><h3 class="cms-block cms-block-heading" style="background-color: white; box-sizing: inherit; letter-spacing: -0.03em; line-height: 1.5; margin-bottom: 0.35em;"><span style="font-family: Public Sans; font-size: medium;">BMI basics</span></h3><p style="background-color: white; box-sizing: inherit; margin-bottom: 25px; margin-top: 0px;"><span style="font-family: Public Sans; font-size: medium;"><a class="link-external" href="https://www.nhlbi.nih.gov/health/educational/lose_wt/BMI/bmicalc.htm" rel="nofollow noopener" style="background-color: transparent; box-sizing: inherit;" target="_blank">Body mass index is a measurement</a> taken by dividing body weight in kilogrammes by height in metres squared. The metric was developed to estimate a normal body weight <a class="link-external" href="https://doi.org/10.1016/0021-9681(72)90027-6" rel="nofollow noopener" style="background-color: transparent; box-sizing: inherit;" target="_blank">depending on an individual’s height</a>, given that taller people tend to weigh more.</span></p><p style="background-color: white; box-sizing: inherit; margin-bottom: 25px;"><span style="font-family: Public Sans; font-size: medium;">It rose to prominence for clinicians in the 1990s following the World Health Organization’s adoption of the metric as the <a class="link-external" href="https://pubmed.ncbi.nlm.nih.gov/8594834/" rel="nofollow noopener" style="background-color: transparent; box-sizing: inherit;" target="_blank">official screening index for obesity</a>.</span></p><p style="background-color: white; box-sizing: inherit; margin-bottom: 25px;"><span style="font-family: Public Sans; font-size: medium;">Research has consistently shown that BMI at a population level <a class="link-external" href="https://doi.org/10.1177/193229680800200623" rel="nofollow noopener" style="background-color: transparent; box-sizing: inherit;" target="_blank">correlates strongly with body fat percentage</a> and risk for <a class="link-external" href="https://www.cdc.gov/healthyweight/effects/index.html" rel="nofollow noopener" style="background-color: transparent; box-sizing: inherit;" target="_blank">serious health conditions</a>. The index is easy to measure and inexpensive to calculate, allowing its wide implementation in health care settings.</span></p><p style="background-color: white; box-sizing: inherit; margin-bottom: 25px;"><span style="font-family: Public Sans; font-size: medium;">The House of Delegates adopted new policy recognizing the issues with using BMI as a measurement because:</span></p><p style="background-color: white; box-sizing: inherit; margin-bottom: 25px;"></p><ul style="text-align: left;"><li><span style="font-family: Public Sans; font-size: medium;">Of the historical harm of BMI.</span></li><li><span style="font-family: Public Sans; font-size: medium;">Of the use of BMI for racist exclusion.</span></li></ul><p></p><p style="background-color: white; box-sizing: inherit; margin-bottom: 25px;"><span style="font-family: Public Sans; font-size: medium;">BMI cutoffs are based primarily on data collected from previous generations of non-Hispanic white populations and does not consider a person’s gender or ethnicity.</span></p><p style="background-color: white; box-sizing: inherit; margin-bottom: 25px;"><span style="font-family: Public Sans; font-size: medium;">In addition, the policy says, there are significant limitations associated with the widespread use of BMI in clinical settings and suggests its use be in a conjunction with other valid measures of risk such as, but not limited to, measurements of:</span></p><p style="background-color: white; box-sizing: inherit; margin-bottom: 25px;"></p><ul style="text-align: left;"><li><span style="font-family: Public Sans; font-size: medium;">Visceral fat.</span></li><li><span style="font-family: Public Sans; font-size: medium;">Body adiposity index.</span></li><li><span style="font-family: Public Sans; font-size: medium;">Body composition.</span></li><li><span style="font-family: Public Sans; font-size: medium;">Relative fat mass.</span></li><li><span style="font-family: Public Sans; font-size: medium;">Waist circumference.</span></li><li><span style="font-family: Public Sans; font-size: medium;">Genetic or metabolic factors.</span></li></ul><p></p><p style="background-color: white; box-sizing: inherit; margin-bottom: 25px;"><span style="font-family: Public Sans; font-size: medium;">The newly adopted AMA policy also states that:</span></p><p style="background-color: white; box-sizing: inherit; margin-bottom: 25px;"></p><ul style="text-align: left;"><li><span style="font-family: Public Sans; font-size: medium;">BMI is significantly correlated with the amount of fat mass in the general population but loses predictability when applied on the individual level.</span></li><li><span style="font-family: Public Sans; font-size: medium;">Relative body shape and composition heterogeneity across race and ethnic groups, sexes, genders and age-span is essential to consider when applying BMI as a measure of adiposity.</span></li><li><span style="font-family: Public Sans; font-size: medium;">The use of BMI should not be used as a sole criterion to deny appropriate insurance reimbursement.</span></li></ul><p></p><p style="background-color: white; box-sizing: inherit; margin-bottom: 25px;"><em style="box-sizing: inherit;"><span style="font-family: Public Sans; font-size: medium;">This article was first published on <a class="link-external" href="https://theconversation.com/bmi-alone-will-no-longer-be-treated-as-the-go-to-measure-for-weight-management-an-obesity-medicine-physician-explains-the-seismic-shift-taking-place-208174" rel="nofollow noopener" style="background-color: transparent; box-sizing: inherit;" target="_blank">The Conversation</a>.</span></em></p>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-749025389762141602023-06-30T00:08:00.009-07:002023-06-30T00:50:00.161-07:00Miracle Drug May Slow Evolution Of Antibiotic Resistance In Bacteria<p><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: #fcfcfc; font-variant-ligatures: common-ligatures;">A team of researchers recently published a report on a drug that significantly reduces the ability of bacteria to evolve antibiotic resistance, both in laboratory cultures and in live animal models. This drug inhibits activation of the stress response in a common gut bacteria,</span><span style="background-color: #fcfcfc; font-variant-ligatures: common-ligatures;"> </span><em style="box-sizing: inherit; font-variant-ligatures: common-ligatures;">Escherichia coli</em><span style="background-color: #fcfcfc; font-variant-ligatures: common-ligatures;">,</span><em style="box-sizing: inherit; font-variant-ligatures: common-ligatures;"> E. coli</em><span style="background-color: #fcfcfc; font-variant-ligatures: common-ligatures;">, which creates new mutations as it repairs breaks in bacterial DNA. These stress response mutations not only confer resistance to antibiotics, but can also create new mutations that create resistance to antibiotics that have never been encountered before. Thus, blocking this stress response may prolong antibiotic effectiveness.</span></span></p><p><span style="font-family: Public Sans; font-size: medium;"></span></p><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Public Sans; font-size: medium;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjZu4KTfceNl4O2cO_UVOWXdaHbfriux6wocfu7gmXw_WJoa3IyeSS6TWey6sQj9K6zhZxeW-FvuOLF6OgzyzKtcn3La6ofzAu_kuAujvN9pAgP_HdkBvxHTe7pohMdNRUnARfyO__aDEBObV1WU_P-0qPJJksTOYK4wUW1Csi3AmyMXsEize1kY6ZvuYw/s1200/file-20190603-69083-1udxh77.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="1200" data-original-width="1200" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjZu4KTfceNl4O2cO_UVOWXdaHbfriux6wocfu7gmXw_WJoa3IyeSS6TWey6sQj9K6zhZxeW-FvuOLF6OgzyzKtcn3La6ofzAu_kuAujvN9pAgP_HdkBvxHTe7pohMdNRUnARfyO__aDEBObV1WU_P-0qPJJksTOYK4wUW1Csi3AmyMXsEize1kY6ZvuYw/s16000/file-20190603-69083-1udxh77.png" /></a></span></div><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: #fcfcfc; font-variant-ligatures: common-ligatures;"><br /></span></span><p></p><p style="background-color: #fcfcfc; box-sizing: inherit; font-variant-ligatures: common-ligatures; margin: 0px 0px 1.2rem;"><span style="font-family: Public Sans; font-size: medium;">“Most people with bacterial infections get better after completing antibiotic treatment, but there are also many cases in which people decline because the bacteria develop resistance to the antibiotic, which then can no longer kill the bacteria,” senior author Susan Rosenberg, who is the Ben F. Love Chair in Cancer Research and professor of molecular and human genetics, of biochemistry and molecular biology, and of molecular virology and microbiology at <a aria-label="Baylor University" class="color-link" data-ga-track="ExternalLink:https://www.baylor.edu/" href="https://www.baylor.edu/" rel="nofollow noopener noreferrer" style="background-color: transparent; box-sizing: inherit; cursor: pointer; text-decoration-line: none;" target="_blank" title="https://www.baylor.edu/">Baylor University</a> said in a statement.</span></p><p style="background-color: #fcfcfc; box-sizing: inherit; font-variant-ligatures: common-ligatures; margin: 0px 0px 1.2rem;"><span style="font-family: Public Sans; font-size: medium;">To do this study, Professor Rosenberg and collaborators screened 1,120 drugs approved in the United States and in the European Union for human use, seeking those that could prevent or slow the evolution of antibiotic resistance in <em style="box-sizing: inherit;">E coli</em> when these bacteria were exposed to a third antibiotic, ciprofloxacin (cipro). Previous studies have found that stress responses in bacteria can be initiated by low concentrations of cipro that occur at the beginning and end of a course of antibiotic treatment, or when antibiotic doses are missed.</span></p><p style="background-color: #fcfcfc; box-sizing: inherit; font-variant-ligatures: common-ligatures; margin: 0px 0px 1.2rem;"><span style="font-family: Public Sans; font-size: medium;">Cipro is the second most prescribed antibiotic in the United States. Professor Rosenberg’s research groups, and many outside labs as well, previously found that bacterial cultures exposed to cipro showed increased rates of genetic mutations. This is because cipro stresses bacteria by creating breaks in bacterial DNA. These DNA breaks accumulate and trigger a genetic stress response to repair them.</span></p><p style="background-color: #fcfcfc; box-sizing: inherit; font-variant-ligatures: common-ligatures; margin: 0px 0px 1.2rem;"><span style="font-family: Public Sans; font-size: medium;">“We found that DEQ fulfilled both requirements,” lead author Yin Zhai, a postdoctoral associate in the Rosenberg lab said in a <a aria-label="statement" class="color-link" data-ga-track="ExternalLink:https://medicalxpress.com/news/2023-06-drug-significantly-bacteria-ability-antibiotic.html" href="https://medicalxpress.com/news/2023-06-drug-significantly-bacteria-ability-antibiotic.html" rel="nofollow noopener noreferrer" style="background-color: transparent; box-sizing: inherit; cursor: pointer; text-decoration-line: none;" target="_blank" title="https://medicalxpress.com/news/2023-06-drug-significantly-bacteria-ability-antibiotic.html">statement</a>. “Given together with cipro, DEQ reduced the development of mutations that confer antibiotic resistance, both in laboratory cultures and in animal models of infection, and bacteria did not develop resistance to DEQ.”</span></p><p style="background-color: #fcfcfc; box-sizing: inherit; font-variant-ligatures: common-ligatures; margin: 0px 0px 1.2rem;"><span style="font-family: Public Sans; font-size: medium;">This is really good news since so many antibiotics are rendered ineffective almost as soon as they are available for use, even for infections that have never before seen these new antibiotics.</span></p><p style="background-color: #fcfcfc; box-sizing: inherit; font-variant-ligatures: common-ligatures; margin: 0px 0px 1.2rem;"><span style="font-family: Public Sans; font-size: medium;">“In addition, we achieved this mutation-slowing effect at low DEQ concentrations, which is promising for patients,” Dr Zhai pointed out. “Future clinical trials are needed to evaluate the ability of DEQ to decelerate bacterial antibiotic resistance in patients.”</span></p><h2 class="subhead-embed color-accent bg-base font-accent font-size text-align" style="background-color: #fcfcfc; box-sizing: inherit; font-variant-ligatures: common-ligatures; line-height: 1.25; margin-block: 0px; margin: 1.2rem 0px;"><span style="font-family: Public Sans; font-size: medium;">Source:</span></h2><p style="background-color: #fcfcfc; box-sizing: inherit; font-variant-ligatures: common-ligatures; margin: 0px 0px 1.2rem;"><span style="font-family: Public Sans; font-size: medium;">Yin Zhai, John P. Pribis, SeanW. Dooling, Libertad Garcia-Villada, P.J. Minnick, Jun Xia, Jingjing Liu, Qian Mei, Devon M. Fitzgerald, Christophe Herman, P.J. Hastings, Mauro Costa-Mattioli and Susan M. Rosenberg (2023). <span style="box-sizing: inherit; font-weight: 700;">Drugging evolution of antibiotic resistance at a regulatory network hub, </span><em style="box-sizing: inherit;">Science Advances</em>, 9(25) | doi:<a aria-label="10.1126/sciadv.adg0188" class="color-link" data-ga-track="ExternalLink:https://doi.org/10.1126/sciadv.adg0188" href="https://doi.org/10.1126/sciadv.adg0188" rel="nofollow noopener noreferrer" style="background-color: transparent; box-sizing: inherit; cursor: pointer; text-decoration-line: none;" target="_blank" title="https://doi.org/10.1126/sciadv.adg0188">10.1126/sciadv.adg0188</a></span></p>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-26828761026544950722023-06-30T00:07:00.007-07:002023-06-30T00:58:22.048-07:00Tirzepatide Triumphs in Significant Weight Reduction For People With Type 2 Diabetes<p><span style="font-family: Public Sans; font-size: medium;"><span face="open-sans, sans-serif" style="background-color: white;">In a recent article published in The</span><span face="open-sans, sans-serif" style="background-color: white;"> </span><a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01200-X/fulltext" rel="noopener" style="border-bottom: 1px solid rgb(154, 154, 154); box-sizing: border-box; cursor: pointer; overflow-wrap: break-word; text-decoration-line: none; transition: all 0.15s ease-out 0s;" target="_blank">Lancet</a><span face="open-sans, sans-serif" style="background-color: white;">, researchers performed a double-blinded, placebo-controlled phase III randomized clinical trial (RCT) SURMOUNT-2 in seven countries between March 29, 2021, and April 10, 2023.</span></span></p><p><span style="font-family: Public Sans; font-size: medium;"><span face="open-sans, sans-serif" style="background-color: white;"><br /></span></span></p><p><span style="font-family: Public Sans; font-size: medium;"></span></p><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Public Sans; font-size: medium;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi1pUiv6M1FUnRdeQs9cwl2UkfjjGRfvS3-37nUvwmcjD6r6RwkPq4ui5E0wB-9gWJT3iuQ1I43WCw0zXyZIJ_qKOEtMSR7XzQeBWTL8eDuqzTtkXG4AItSoIw4kbmxqMDNazLyES9KBKRvLxgNyGhIn_hUAxwE4X8hasa5yUp-nkuMSZboNC-FLJQ2rk0/s2560/tirzepatide-5.8.2023-scaled-e1683241658726.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="1318" data-original-width="2560" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi1pUiv6M1FUnRdeQs9cwl2UkfjjGRfvS3-37nUvwmcjD6r6RwkPq4ui5E0wB-9gWJT3iuQ1I43WCw0zXyZIJ_qKOEtMSR7XzQeBWTL8eDuqzTtkXG4AItSoIw4kbmxqMDNazLyES9KBKRvLxgNyGhIn_hUAxwE4X8hasa5yUp-nkuMSZboNC-FLJQ2rk0/s16000/tirzepatide-5.8.2023-scaled-e1683241658726.jpg" /></a></span></div><span style="font-family: Public Sans; font-size: medium;"><span face="open-sans, sans-serif" style="background-color: white;"><br /></span></span><p></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">The study included adults aged ≥18 years with a body-mass index (BMI)≥ 27 kg/m2, with glycated hemoglobin (HbA1c) of 7–10, and type 2 diabetes (T2D). The study aimed to assess the effectiveness and safety of tirzepatide vs. placebo as a weight management treatment.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">Specifically, they evaluated the safety profile and <a class="linked-term" href="https://www.news-medical.net/health/What-Does-Efficacy-Mean.aspx" style="background-color: transparent; border-bottom: 1px solid rgb(154, 154, 154); box-sizing: border-box; cursor: pointer; overflow-wrap: break-word; text-decoration-line: none; transition: all 0.15s ease-out 0s;">efficacy of</a> 10 or 15mg subcutaneous tirzepatide, a glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) receptor agonist, or placebo for 72 weeks, when given once weekly.</span></p><h2 style="background: none rgb(255, 255, 255); box-sizing: border-box; clear: left; line-height: 1.1; margin-bottom: 10px; margin-top: 0px; padding: 8px 8px 8px 0px; width: 673.324px;"><span style="font-family: Public Sans; font-size: medium;">Background</span></h2><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">Obesity raises the risk of nearly 200 weight-related issues, of which type two diabetes (T2D), cardiovascular diseases (CVDs), and chronic kidney disease are fatal. The American and European Diabetes Associations agree that 5 to 15% weight reduction is key to T2D management and translates to health benefits beyond glycaemic control.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">In fact, greater bodyweight reduction (≥10%) improves cardiometabolic risk factors, which can even lead to remission of diabetes.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">In a previous clinical trial, tirzepatide treatment reduced body weight by up to 20.9% after 72 weeks in obese people who did not suffer from T2D, besides improving other health-related outcomes in a dose-dependent manner.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">Its GIP and GLP-1 receptor agonist activity synergized glucose and lipid homeostasis that governs food consumption and appetite.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">Thus, the United States Food and Drug Administration (FDA) and European Medicines Agency (EMA) approved tirzepatide to treat T2D in adults.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">The molecule is also under development for chronic weight management. However, studies in obese people with T2D often have less weight reduction in response to anti-obesity medication treatment than those without diabetes.</span></p><h2 style="background: none rgb(255, 255, 255); box-sizing: border-box; clear: left; line-height: 1.1; margin-bottom: 10px; margin-top: 0px; padding: 8px 8px 8px 0px; width: 673.324px;"><span style="font-family: Public Sans; font-size: medium;">About the study</span></h2><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">In the present phase III SURMOUNT trial of tirzepatide, researchers investigated its efficacy and safety as a chronic weight reduction and maintenance treatment.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">Accordingly, they designed this 72-week trial and conducted it in 77 sites (multicenter) across India, Argentina, Japan, Brazil, Russia, the USA, and Taiwan. All study participants received diet, exercise, or oral antihyperglycaemic medication for T2D management three months before study screening which lasted three weeks.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">The team randomly assigned (1:1:1) all participants to receive tirzepatide 10 mg, 15 mg, or placebo, which they administered subcutaneously using a single-dose pen for 72 weeks. There was a four-week safety follow-up period following the treatment period.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">First, the team-initiated treatment with 2·5 mg once weekly tirzepatide (or matching placebo) and increased the dose by 2·5 mg every four weeks until they reached the target dose, i.e., 10 or 15 mg, sometime between 12 and 20 weeks. </span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">This trial had two coprimary endpoints; first, the researchers determined the percent change in body weight from baseline to week 72, and second, they assessed weight reduction from baseline of at least 5% at week 72. </span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">The team controlled for type one error rate in secondary endpoints, specifically for bodyweight reductions of 10%, 15%, and 20% at week 72. Likewise, they assessed the change from baseline in HbA1c, fasting glucose, waist size, systolic blood pressure, and fasting lipid concentrations at week 72.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">In a post hoc analysis, the team evaluated the change in the number of antihyperglycaemic medications participants took by week 72. The safety endpoints of the study included treatment-emergent adverse and serious adverse events, level two or three hypoglycemia accompanied by severe cognitive impairment.</span></p><h2 style="background: none rgb(255, 255, 255); box-sizing: border-box; clear: left; line-height: 1.1; margin-bottom: 10px; margin-top: 0px; padding: 8px 8px 8px 0px; width: 673.324px;"><span style="font-family: Public Sans; font-size: medium;">Results</span></h2><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">The researchers screened 1,514 participants for eligibility during the study period, enrolling 938 participants. Next, they randomly assigned 312, 311, and 315 enrolees to receive tirzepatide 10 mg, tirzepatide 15 mg, and a matching placebo, which comprised the study's intent to treat the population.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">In study participants with a BMI≥ 27 kg/m2 and T2D, tirzepatide 10 mg and 15 mg once weekly doses reduced body weight by 12·8% and 14·7%, respectively, vs. 3·2% with placebo. </span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">Encouragingly, up to 83% of participants treated with tirzepatide attained clinically significant ≥5% weight reduction, with up to 50% and one-third of the participants reaching 15% or higher and 20% or higher weight reduction. </span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">Also, 49% of the tirzepatide-treated participants reached normoglycaemia, i.e., HbA1c <5·7%, whereas only 3% attained this benchmark in the placebo group. More importantly, there were no cases of severe hypoglycemia among those reaching this HbA1c target post-tirzepatide treatment.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">In addition, drug treatment triggered only mild to moderate gastrointestinal events in some participants, e.g., diarrhea and nausea.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">Furthermore, tirzepatide treatment markedly improved the cardiometabolic risk factors of study participants. Examples include systolic BP, fasting triglycerides, and high- and non-high-density lipoprotein cholesterol. </span></p><h2 style="background: none rgb(255, 255, 255); box-sizing: border-box; clear: left; line-height: 1.1; margin-bottom: 10px; margin-top: 0px; padding: 8px 8px 8px 0px; width: 673.324px;"><span style="font-family: Public Sans; font-size: medium;">Conclusions</span></h2><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">According to the authors, SURMOUNT-2 is one of the first RCTs of tirzepatide conducted in obese adults with T2D that assessed body weight reduction and not HbA1c reduction as the primary outcome.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">Both 10 and 15 mg tirzepatide doses conferred clinically significant bodyweight reductions accompanied by improved HbA1c and other cardiometabolic risk factors. It attained a body weight reduction that exceeded levels of weight reduction of approved anti-obesity medications.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">This trial brought forth a promising treatment for obese <a class="linked-term" href="https://www.news-medical.net/health/What-is-Type-2-Diabetes.aspx" style="background-color: transparent; border-bottom: 1px solid rgb(154, 154, 154); box-sizing: border-box; cursor: pointer; overflow-wrap: break-word; text-decoration-line: none; transition: all 0.15s ease-out 0s;">people with type 2 diabetes</a>.</span></p><div class="content-source" id="sources" style="background-color: white; border-bottom-color: rgb(182, 181, 181); border-bottom-style: solid; border-image: initial; border-left-color: initial; border-left-style: initial; border-right-color: initial; border-right-style: initial; border-top-color: rgb(182, 181, 181); border-top-style: solid; border-width: 1px 0px; box-sizing: border-box; clear: both; margin: 13px auto 0px; padding: 8px 0px;"><div class="content-src-label" style="box-sizing: border-box; font-weight: bold;"><span style="font-family: Public Sans; font-size: medium;">Journal reference:</span></div><div class="content-src-value" style="box-sizing: border-box; margin-top: 2px;"><ul style="box-sizing: border-box; margin-bottom: 25px; margin-top: 0px;"><li style="box-sizing: border-box; line-height: 1.58em;"><p style="box-sizing: border-box; line-height: 1.58em; margin: 0px;"><span style="font-family: Public Sans; font-size: medium;">Timothy G, et al. (2023) Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial., The Lancet., <strong style="box-sizing: border-box;">doi</strong>: <a href="https://doi.org/10.1016/S0140-6736(23)01200-X" rel="noopener" style="background-color: transparent; border-bottom: 0px; box-sizing: border-box; cursor: pointer; overflow-wrap: break-word; text-decoration-line: none; transition: all 0.15s ease-out 0s;" target="_blank">10.1016/S0140-6736(23)01200-X</a>. <a href="http://timothy%20g%2C%20et%20al.%20%282023%29%20tirzepatide%20once%20weekly%20for%20the%20treatment%20of%20obesity%20in%20people%20with%20type%202%20diabetes%20%28surmount-2%29:%20a%20double-blind%2C%20randomised%2C%20multicentre%2C%20placebo-controlled%2C%20phase%203%20trial.%2C%20the%20lancet.%2C%20doi:%2010.1016/S0140-6736(23)01200-X.%20https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01200-X/fulltext" rel="noopener" style="background-color: transparent; border-bottom: 0px; box-sizing: border-box; cursor: pointer; overflow-wrap: break-word; text-decoration-line: none; transition: all 0.15s ease-out 0s;" target="_blank">https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01200-X/fulltext</a></span></p></li></ul></div></div>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-9739310349370602832023-06-29T23:49:00.006-07:002023-06-30T00:56:48.907-07:00Vitamin D Supplements May Reduce Risk of Heart Attacks in Older Adults<p><span style="font-family: Public Sans; font-size: medium;"><span face="open-sans, sans-serif" style="background-color: white;">Vitamin D supplements may reduce the risk of major cardiovascular events such as heart attacks among people aged over 60, finds a clinical trial published by</span><span face="open-sans, sans-serif" style="background-color: white;"> </span><em style="box-sizing: border-box;">The BMJ</em><span face="open-sans, sans-serif" style="background-color: white;">.</span></span></p><p><span style="font-family: Public Sans; font-size: medium;"></span></p><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Public Sans; font-size: medium;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhMuvW6nQlDFy5iNCZTfQUNFS9am4nYRnKfrXPhpoFXHCFtzEYA0npz0CjvNiWBIdppIf9LsMiC0ye8aGO4ZC1IQkQrVTceamfMzV419DTx5qC5-Sx-Jh90MLaxnNF3TJmZi8yILmqrCva7OLH0EfZPt95O8ER5Udi-YheVn32cawsZp8nr3oPZheHXwqg/s630/Vitamin-D-supplements.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="380" data-original-width="630" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhMuvW6nQlDFy5iNCZTfQUNFS9am4nYRnKfrXPhpoFXHCFtzEYA0npz0CjvNiWBIdppIf9LsMiC0ye8aGO4ZC1IQkQrVTceamfMzV419DTx5qC5-Sx-Jh90MLaxnNF3TJmZi8yILmqrCva7OLH0EfZPt95O8ER5Udi-YheVn32cawsZp8nr3oPZheHXwqg/s16000/Vitamin-D-supplements.jpg" /></a></span></div><span style="font-family: Public Sans; font-size: medium;"><span face="open-sans, sans-serif" style="background-color: white;"><br /></span></span><p></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">The researchers stress that the absolute risk difference was small, but say this is the largest trial of its kind to date, and further evaluation is warranted, particularly in people taking statins or other cardiovascular disease drugs.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">Cardiovascular disease (CVD) is a general term for conditions affecting the heart or blood vessels and is one of the main causes of death globally. CVD events such as heart attacks and strokes are set to increase as populations continue to age and chronic diseases become more common.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">Observational studies have consistently shown a link between vitamin D levels and CVD risk, but randomised controlled trials have found no evidence that vitamin D supplements prevent cardiovascular events, possibly due to differences in trial design that can affect results.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">To address this uncertainty, researchers in Australia set out to investigate whether supplementing older adults with monthly doses of vitamin D alters the rate of major cardiovascular events.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">Their D-Health Trial was carried out from 2014 to 2020 and involved 21,315 Australians aged 60-84 who randomly received one capsule of either 60,000 IU vitamin D (10,662 participants) or placebo (10,653 participants) taken orally at the beginning of each month for up to 5 years.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">Participants with a history of high calcium levels (hypercalcemia), overactive thyroid (hyperparathyroidism), kidney stones, soft bones (osteomalacia), sarcoidosis, an inflammatory disease, or those already taking more than 500 IU/day vitamin D were excluded.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">Data on hospital admissions and deaths were then used to identify major cardiovascular events, including heart attacks, strokes, and coronary revascularisation (treatment to restore normal blood flow to the heart).</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">The average treatment duration was 5 years and more than 80% of participants reported taking at least 80% of the study tablets.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">During the trial, 1,336 participants experienced a major cardiovascular event (6.6% in the placebo group and 6% in the vitamin D group).</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">The rate of major cardiovascular events was 9% lower in the vitamin D compared with the placebo group (equivalent to 5.8 fewer events per 1,000 participants).</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">The rate of heart attack was 19% lower and the rate of coronary revascularization was 11% lower in the vitamin D group, but there was no difference in the rate of stroke between the two groups.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">There was some indication of a stronger effect in those who were using statins or other cardiovascular drugs at the start of the trial, but the researchers say these results were not statistically significant.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">Overall, the researchers calculate that 172 people would need to take monthly vitamin D supplements to prevent one major cardiovascular event.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">The researchers acknowledge that there may be a small underestimate of events and say the findings may not apply to other populations, particularly those where a higher proportion of people are vitamin D deficient. However, this was a large trial with extremely high retention and adherence, and almost complete data on cardiovascular events and mortality outcomes.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">As such, they say their findings suggest that vitamin D supplementation may reduce the risk of major cardiovascular events. "This protective effect could be more marked in those taking statins or other cardiovascular drugs at baseline," they add, and they suggest further evaluation is needed to help to clarify this issue.</span></p><p style="background-color: white; box-sizing: border-box; line-height: 1.58em; margin: 0px 0px 25px;"><span style="font-family: Public Sans; font-size: medium;">"In the meantime, these findings suggest that conclusions that vitamin D supplementation does not alter risk of cardiovascular disease are premature," they conclude.</span></p><div class="content-source" id="sources" style="background-color: white; border-bottom-color: rgb(182, 181, 181); border-bottom-style: solid; border-image: initial; border-left-color: initial; border-left-style: initial; border-right-color: initial; border-right-style: initial; border-top-color: rgb(182, 181, 181); border-top-style: solid; border-width: 1px 0px; box-sizing: border-box; clear: both; margin: 13px auto 0px; padding: 8px 0px;"><div class="content-src-label" style="box-sizing: border-box; font-weight: bold;"><span style="font-family: Public Sans; font-size: medium;">Source:</span></div><div class="content-src-value" style="box-sizing: border-box; margin-top: 2px;"><p style="box-sizing: border-box; line-height: 1.58em; margin: 0px;"><a href="https://www.bmj.com/" rel="noopener" style="background-color: transparent; border-bottom: 0px; box-sizing: border-box; cursor: pointer; overflow-wrap: break-word; text-decoration-line: none; transition: all 0.15s ease-out 0s;" target="_blank"><span style="color: black; font-family: Public Sans; font-size: medium;">BMJ</span></a></p></div><div class="content-src-label" style="box-sizing: border-box; font-weight: bold;"><span style="font-family: Public Sans; font-size: medium;">Journal reference:</span></div><div class="content-src-value" style="box-sizing: border-box; margin-top: 2px;"><p style="box-sizing: border-box; line-height: 1.58em; margin: 0px;"><span style="font-family: Public Sans; font-size: medium;">Thompson, B., <em style="box-sizing: border-box;">et al.</em> (2023) Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial<em style="box-sizing: border-box;">.</em> <em style="box-sizing: border-box;">BMJ</em>. <a href="https://doi.org/10.1136/bmj-2023-075230" rel="noopener" style="background-color: transparent; border-bottom: 0px; box-sizing: border-box; cursor: pointer; overflow-wrap: break-word; text-decoration-line: none; transition: all 0.15s ease-out 0s;" target="_blank">doi.org/10.1136/bmj-2023-075230</a>.</span></p></div></div>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-54599641057860558732023-06-29T23:03:00.008-07:002023-06-29T23:18:56.226-07:00Metformin: The Diabetes Drug That Could Prevent Long COVID<p><span style="font-family: Public Sans;"><span style="background-color: white; font-size: 17.008px;">In a new study published in</span><em style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"> <span aria-describedby="tt" class="glossaryLink" data-cmtooltip="<div class=glossaryItemTitle>The Lancet</div><div class=glossaryItemBody>Founded in 1823 by Thomas Wakley, The Lancet is a weekly peer-reviewed general medical journal. It is one of the world&#039;s oldest, most prestigious, and best known general medical journals. The journal publishes original research articles, review articles (&quot;seminars&quot; and &quot;reviews&quot;), editorials, book reviews, correspondence, as well as news features and case reports. The Lancet has editorial offices in London, New York, and Beijing.&nbsp;</div>" data-gt-translate-attributes="[{"attribute":"data-cmtooltip", "format":"html"}]" style="border-bottom-color: rgb(0, 0, 0); border-bottom-style: dotted; border-image: initial; border-left-color: initial; border-left-style: initial; border-right-color: initial; border-right-style: initial; border-top-color: initial; border-top-style: initial; border-width: 0px 0px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">The Lancet</span> Infectious Diseases</em><em style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">,</em><span style="background-color: white; font-size: 17.008px;"> University of Minnesota researchers found that metformin, a drug commonly used to treat diabetes, prevents the development of long COVID.</span></span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;"><span class="ezoic-adpicker-ad" id="ezoic-pub-ad-placeholder-170" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span>The study, called <a href="https://covidout.umn.edu/" style="border: 0px; color: #005a8c; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: 600; line-height: inherit; margin: 0px; padding: 0px; text-decoration-line: none; transition: all 0.5s ease 0s; vertical-align: baseline;">COVID-OUT</a>, investigated if early outpatient <span aria-describedby="tt" class="glossaryLink" data-cmtooltip="<div class=glossaryItemTitle>COVID-19</div><div class=glossaryItemBody>First identified in 2019 in Wuhan, China, COVID-19, or Coronavirus disease 2019, (which was originally called &quot;2019 novel coronavirus&quot; or 2019-nCoV) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has spread globally, resulting in the 2019–22 coronavirus pandemic.</div>" data-gt-translate-attributes="[{"attribute":"data-cmtooltip", "format":"html"}]" style="border-bottom-color: rgb(0, 0, 0); border-bottom-style: dotted; border-image: initial; border-left-color: initial; border-left-style: initial; border-right-color: initial; border-right-style: initial; border-top-color: initial; border-top-style: initial; border-width: 0px 0px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">COVID-19</span> treatment with metformin, ivermectin, or fluvoxamine could prevent long COVID. Long COVID is a chronic illness that can affect up to 10% of people who have had COVID-19.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjCCT-vim0g0dvpUj5YTZO41Yp4ichTaadCvxpgwCAvfjqxg2AErqHwFxkL3-qA63DolhOFJ-gHh_Hc_tjeSSn3_eTQCnyLfCW42MIa-IktkealqSyRqy7-WVHOiK8Pq2t7NcsJq4TKxCyKbN2Gu8qTSPlSqwPKyBlX_BZQJ5FdQRKOlcpEplrJ8hovSVU/s1200/Metformin-Benefits-side-effects-dosage-and-research.webp" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="800" data-original-width="1200" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjCCT-vim0g0dvpUj5YTZO41Yp4ichTaadCvxpgwCAvfjqxg2AErqHwFxkL3-qA63DolhOFJ-gHh_Hc_tjeSSn3_eTQCnyLfCW42MIa-IktkealqSyRqy7-WVHOiK8Pq2t7NcsJq4TKxCyKbN2Gu8qTSPlSqwPKyBlX_BZQJ5FdQRKOlcpEplrJ8hovSVU/s16000/Metformin-Benefits-side-effects-dosage-and-research.webp" /></a></div><span style="font-family: Public Sans;"><br /></span><p></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">“The results of this study are important because long COVID can have a significant impact on people’s lives,” said Carolyn Bramante, MD, principal investigator and an assistant professor at the U of M Medical School. “Metformin is an inexpensive, safe and widely available drug, and its use as a preventive measure could have significant public health implications.”</span></p><div id="ezwrap_medianet_queue_0" style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><div id="974871025" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></div></div><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;"><span class="ezoic-adpicker-ad" id="ezoic-pub-ad-placeholder-606" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span>This was a large, placebo-controlled randomized clinical trial that enrolled volunteers across the United States. The study found:</span></p><ul style="background-color: white; border: 0px; box-sizing: border-box; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; list-style: square; margin: 0px 0px 1.875rem 2.5rem; padding: 0px; vertical-align: baseline;"><li style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">Those who received metformin were more than 40% less likely to develop long COVID than those who received an identical-looking placebo.</span></li><li style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">For participants who started metformin less than four days after their COVID symptoms started, metformin decreased the risk of long COVID by 63%.</span></li><li style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">The effect was consistent across different demographic populations of volunteers who participated and across multiple viral variants, including the Omicron variant.</span></li><li style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">Ivermectin and fluvoxamine did not prevent long COVID.</span></li></ul><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">The study included more than 1,200 participants who were randomly chosen to receive either metformin or placebo, and an additional subset received ivermectin, fluvoxamine or their placebos. Participants were between 30 and 85 years old who qualified as overweight or obese. Over 1,100 of the participants reported on their symptoms for up to 10 months after their initial COVID-19 diagnosis.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">“This long-term outcome from a randomized trial is high-quality evidence that metformin prevents harm from the <span aria-describedby="tt" class="glossaryLink" data-cmtooltip="<div class=glossaryItemTitle>SARS-CoV-2</div><div class=glossaryItemBody>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the official name of the virus strain that causes coronavirus disease (COVID-19). Previous to this name being adopted, it was commonly referred to as the 2019 novel coronavirus (2019-nCoV), the Wuhan coronavirus, or the Wuhan virus.</div>" data-gt-translate-attributes="[{"attribute":"data-cmtooltip", "format":"html"}]" style="border-bottom-color: rgb(0, 0, 0); border-bottom-style: dotted; border-image: initial; border-left-color: initial; border-left-style: initial; border-right-color: initial; border-right-style: initial; border-top-color: initial; border-top-style: initial; border-width: 0px 0px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">SARS-CoV-2</span> <span aria-describedby="tt" class="glossaryLink" data-cmtooltip="<div class=glossaryItemTitle>virus</div><div class=glossaryItemBody>A virus is a tiny infectious agent that is not considered a living organism. It consists of genetic material, either DNA or RNA, that is surrounded by a protein coat called a capsid. Some viruses also have an outer envelope made up of lipids that surrounds the capsid. Viruses can infect a wide range of organisms, including humans, animals, plants, and even bacteria. They rely on host cells to replicate and multiply, hijacking the cell&#039;s machinery to make copies of themselves. This process can cause damage to the host cell and lead to various diseases, ranging from mild to severe. Common viral infections include the flu, colds, HIV, and COVID-19. Vaccines and antiviral medications can help prevent and treat viral infections.</div>" data-gt-translate-attributes="[{"attribute":"data-cmtooltip", "format":"html"}]" style="border-bottom-color: rgb(0, 0, 0); border-bottom-style: dotted; border-image: initial; border-left-color: initial; border-left-style: initial; border-right-color: initial; border-right-style: initial; border-top-color: initial; border-top-style: initial; border-width: 0px 0px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">virus</span>,” said Dr. Bramante, who is also an internist and pediatrician with M Health Fairview. “While half of our trial had been vaccinated, none had been previously infected with the COVID-19 virus. Further research could show whether it is also effective in those with previous infection or in adults with lower body mass index.”<span class="ezoic-adpicker-ad" id="ezoic-pub-ad-placeholder-607" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">Metformin’s ability to stop the virus was <a href="https://cse.umn.edu/bme/news/computer-simulator-helps-steer-covid-19-clinical-trial-toward-promising-treatment" style="border: 0px; color: #005a8c; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: 600; line-height: inherit; margin: 0px; padding: 0px; text-decoration-line: none; transition: all 0.5s ease 0s; vertical-align: baseline;">predicted by a simulator</a> developed by U of M Medical School and College of Science and Engineering Biomedical Engineering faculty. The model has been highly accurate to date, successfully predicting, among others, the failure of <span aria-describedby="tt" class="glossaryLink" data-cmtooltip="<div class=glossaryItemTitle>hydroxychloroquine</div><div class=glossaryItemBody>Hydroxychloroquine (HCQ) is a medication used to prevent and treat malaria in areas where malaria remains sensitive to chloroquine. It was approved for medical use in the United States in 1955 and is sold under the brand name Plaquenil and others.</div>" data-gt-translate-attributes="[{"attribute":"data-cmtooltip", "format":"html"}]" style="border-bottom-color: rgb(0, 0, 0); border-bottom-style: dotted; border-image: initial; border-left-color: initial; border-left-style: initial; border-right-color: initial; border-right-style: initial; border-top-color: initial; border-top-style: initial; border-width: 0px 0px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">hydroxychloroquine</span> and the success of remdesivir before the results of clinical trials testing these therapies were announced.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">Reference: “Outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months (COVID-OUT): a multicentre, randomised, quadruple-blind, parallel-group, phase 3 trial” by Carolyn T Bramante, MD; Prof John B Buse, PhD; David M Liebovitz, MD; Jacinda M Nicklas, MD; Michael A Puskarich, MD; Ken Cohen, MD; Hrishikesh K Belani, MD; Blake J Anderson, MS; Jared D Huling, PhD; Christopher J Tignanelli, MD; Jennifer L Thompson, MD; Matthew Pullen, MD; Esteban Lemus Wirtz, BD; Lianne K Siegel, PhD; Jennifer L Proper, PhD; Prof David J Odde, PhD; Prof Nichole R Klatt, PhD; Prof Nancy E Sherwood, PhD; Sarah M Lindberg, MPH; Amy B Karger, PhD; Kenneth B Beckman, PhD; Spencer M Erickson, BA; Sarah L Fenno, MPH; Katrina M Hartman, BA; Michael R Rose, MD; Tanvi Mehta, BA; Barkha Patel, MS; Gwendolyn Griffiths, BA; Neeta S Bhat, MPH; Thomas A Murray, PhD and Prof David R Boulware, MD, 8 June 2023, <em style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">The Lancet Infectious Diseases</em>.<br /><a href="https://doi.org/10.1016/S1473-3099(23)00299-2" style="border: 0px; color: #005a8c; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: 600; line-height: inherit; margin: 0px; padding: 0px; text-decoration-line: none; transition: all 0.5s ease 0s; vertical-align: baseline;">DOI: 10.1016/S1473-3099(23)00299-2</a></span></p><p></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">The University of Minnesota Medical School, School of Public Health, College of Science and Engineering and M Health Fairview served as the lead site. The trial was also conducted at <span aria-describedby="tt" class="glossaryLink" data-cmtooltip="<div class=glossaryItemTitle>Northwestern University</div><div class=glossaryItemBody>Established in 1851, Northwestern University (NU) is a private research university based in Evanston, Illinois, United States. Northwestern is known for its McCormick School of Engineering and Applied Science, Kellogg School of Management, Feinberg School of Medicine, Pritzker School of Law, Bienen School of Music, and Medill School of Journalism.&nbsp;</div>" data-gt-translate-attributes="[{"attribute":"data-cmtooltip", "format":"html"}]" style="border-bottom-color: rgb(0, 0, 0); border-bottom-style: dotted; border-image: initial; border-left-color: initial; border-left-style: initial; border-right-color: initial; border-right-style: initial; border-top-color: initial; border-top-style: initial; border-width: 0px 0px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Northwestern University</span>; University of Colorado, Denver; Olive View – <span aria-describedby="tt" class="glossaryLink" data-cmtooltip="<div class=glossaryItemTitle>UCLA</div><div class=glossaryItemBody>The University of California, Los Angeles (UCLA) is a public land-grant research university in Los Angeles, California. It is organized into the College of Letters and Science and 12 professional schools. It is considered one of the country&#039;s Public Ivies, and is frequently ranked among the best universities in the world by major college and university rankings.</div>" data-gt-translate-attributes="[{"attribute":"data-cmtooltip", "format":"html"}]" style="border-bottom-color: rgb(0, 0, 0); border-bottom-style: dotted; border-image: initial; border-left-color: initial; border-left-style: initial; border-right-color: initial; border-right-style: initial; border-top-color: initial; border-top-style: initial; border-width: 0px 0px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">UCLA</span> Education & Research Institute in Los Angeles; Optum Health, and with scientific collaboration from partners at the University of North Carolina at Chapel Hill, Vanderbilt University, and Emory University School of Medicine.</span></p><span data-inserter-version="2" id="ezoic-pub-ad-placeholder-112" style="background-color: white; border: 0px; font-family: Public Sans; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">Funding was provided by the Parsemus Foundation, Rainwater Charitable Foundation, Fast Grants, and the United Health Foundation. This research was also supported by the <span aria-describedby="tt" class="glossaryLink" data-cmtooltip="<div class=glossaryItemTitle>National Institutes of Health</div><div class=glossaryItemBody>The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. Founded in 1887, it is a part of the U.S. Department of Health and Human Services. The NIH conducts its own scientific research through its Intramural Research Program (IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program. With 27 different institutes and centers under its umbrella, the NIH covers a broad spectrum of health-related research, including specific diseases, population health, clinical research, and fundamental biological processes. Its mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability.</div>" data-gt-translate-attributes="[{"attribute":"data-cmtooltip", "format":"html"}]" style="border-bottom-color: rgb(0, 0, 0); border-bottom-style: dotted; border-image: initial; border-left-color: initial; border-left-style: initial; border-right-color: initial; border-right-style: initial; border-top-color: initial; border-top-style: initial; border-width: 0px 0px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">National Institutes of Health</span>’s National Center for Advancing Translational Sciences under award number [UL1TR002494, KL2TR002492, and UM1TR004406].</span></p>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-91758562272730179892023-06-29T23:02:00.004-07:002023-06-29T23:02:41.126-07:00New Research Reveals That Junk Food May Disrupt Deep Sleep<p><span style="font-family: Public Sans;"><img alt="Cant Sleep Insomnia Headache" aria-describedby="caption-attachment-258797" class="wp-image-258797 size-large ezlazyloaded" data-ezsrc="https://scitechdaily.com/images/Cant-Sleep-Insomnia-Headache-777x406.jpg?ezimgfmt=rs:727x380/rscb2/ng:webp/ngcb2" data-ezsrcset="https://scitechdaily.com/images/Cant-Sleep-Insomnia-Headache-777x406.jpg?ezimgfmt=ng:webp/ngcb2 777w,https://scitechdaily.com/images/Cant-Sleep-Insomnia-Headache-400x209.jpg?ezimgfmt=ng:webp/ngcb2 400w,https://scitechdaily.com/images/Cant-Sleep-Insomnia-Headache-768x401.jpg?ezimgfmt=ng:webp/ngcb2 768w,https://scitechdaily.com/images/Cant-Sleep-Insomnia-Headache-1536x802.jpg?ezimgfmt=ng:webp/ngcb2 1536w,https://scitechdaily.com/images/Cant-Sleep-Insomnia-Headache.jpg?ezimgfmt=ng:webp/ngcb2 2000w" decoding="async" ezimgfmt="rs rscb2 src ng ngcb2 srcset" ezoid="0.9472413025118154" height="406" sizes="(max-width: 777px) 100vw, 777px" src="https://scitechdaily.com/images/Cant-Sleep-Insomnia-Headache-777x406.jpg?ezimgfmt=rs:727x380/rscb2/ng:webp/ngcb2" srcset="https://scitechdaily.com/images/Cant-Sleep-Insomnia-Headache-777x406.jpg?ezimgfmt=ng:webp/ngcb2 777w,https://scitechdaily.com/images/Cant-Sleep-Insomnia-Headache-400x209.jpg?ezimgfmt=ng:webp/ngcb2 400w,https://scitechdaily.com/images/Cant-Sleep-Insomnia-Headache-768x401.jpg?ezimgfmt=ng:webp/ngcb2 768w,https://scitechdaily.com/images/Cant-Sleep-Insomnia-Headache-1536x802.jpg?ezimgfmt=ng:webp/ngcb2 1536w,https://scitechdaily.com/images/Cant-Sleep-Insomnia-Headache.jpg?ezimgfmt=ng:webp/ngcb2 2000w" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; height: auto; line-height: inherit; margin: 0px; max-width: 100%; padding: 0px; vertical-align: bottom;" width="777" /></span></p><div class="wp-caption aligncenter" id="attachment_258797" style="background-color: white; border: 0px; clear: both; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 1.25rem auto; max-width: 100%; padding: 0px; vertical-align: baseline; width: 787px;"><span style="font-family: Public Sans;"><span class="ezoic-autoinsert-video ezoic-under_first_paragraph" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span><span data-inserter-version="2" id="ezoic-pub-ad-placeholder-102" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></span></div><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">Recent research conducted by <a href="https://scitechdaily.com/tag/uppsala-university/" style="border: 0px; color: #005a8c; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: 600; line-height: inherit; margin: 0px; padding: 0px; text-decoration-line: none; transition: all 0.5s ease 0s; vertical-align: baseline;">Uppsala University</a> examined the impact of junk food on sleep. In a randomized sequence, healthy individuals were given both healthier and less healthy diets. The results indicated a decline in the quality of deep sleep for those who consumed the less healthy diet when compared to those who followed a healthier diet.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;"><span class="ezoic-adpicker-ad" id="ezoic-pub-ad-placeholder-170" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span>The findings were recently published in the journal <em style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Obesity</em>.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">Several epidemiological studies have established a link between diet and alterations in our sleep patterns. However, the direct influence of diet on sleep has been explored by only a few studies. One way to do that is to have the same participant consume different diets in a randomized order.</span></p><div id="ezwrap_medianet_queue_0" style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><div id="974871025" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></div></div><div class="wp-caption alignright" id="attachment_284314" style="background-color: white; border: 0px; display: inline; float: right; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0.3125rem 0px 1.25rem 1.25rem; max-width: 100%; padding: 0px; vertical-align: baseline; width: 370px;"><span style="font-family: Public Sans;"><img alt="Jonathan Cedernaes" aria-describedby="caption-attachment-284314" class="wp-image-284314 ezlazyloaded" data-ezsrc="https://scitechdaily.com/images/Jonathan-Cedernaes-777x519.jpg?ezimgfmt=rs:360x240/rscb2/ng:webp/ngcb2" data-ezsrcset="https://scitechdaily.com/images/Jonathan-Cedernaes-777x519.jpg?ezimgfmt=ng:webp/ngcb2 777w,https://scitechdaily.com/images/Jonathan-Cedernaes-400x267.jpg?ezimgfmt=ng:webp/ngcb2 400w,https://scitechdaily.com/images/Jonathan-Cedernaes-768x513.jpg?ezimgfmt=ng:webp/ngcb2 768w,https://scitechdaily.com/images/Jonathan-Cedernaes-1536x1025.jpg?ezimgfmt=ng:webp/ngcb2 1536w,https://scitechdaily.com/images/Jonathan-Cedernaes.jpg?ezimgfmt=ng:webp/ngcb2 1820w" decoding="async" ezimgfmt="rs rscb2 src ng ngcb2 srcset" ezoid="0.4991597310174618" height="240" loading="lazy" sizes="(max-width: 360px) 100vw, 360px" src="https://scitechdaily.com/images/Jonathan-Cedernaes-777x519.jpg?ezimgfmt=rs:360x240/rscb2/ng:webp/ngcb2" srcset="https://scitechdaily.com/images/Jonathan-Cedernaes-777x519.jpg?ezimgfmt=ng:webp/ngcb2 777w,https://scitechdaily.com/images/Jonathan-Cedernaes-400x267.jpg?ezimgfmt=ng:webp/ngcb2 400w,https://scitechdaily.com/images/Jonathan-Cedernaes-768x513.jpg?ezimgfmt=ng:webp/ngcb2 768w,https://scitechdaily.com/images/Jonathan-Cedernaes-1536x1025.jpg?ezimgfmt=ng:webp/ngcb2 1536w,https://scitechdaily.com/images/Jonathan-Cedernaes.jpg?ezimgfmt=ng:webp/ngcb2 1820w" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; height: auto; line-height: inherit; margin: 0px; max-width: 100%; padding: 0px; vertical-align: bottom;" width="360" /></span><p class="wp-caption-text" id="caption-attachment-284314" style="border: 0px; color: #454545; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 0.875rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: 1.4; margin: 0.3125rem 0px 0px; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">Jonathan Cedernaes, MD Ph.D. and Associate Professor in Medical Cell Biology at Uppsala University. Credit: Antwon McMullen</span></p></div><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;"><span class="ezoic-adpicker-ad" id="ezoic-pub-ad-placeholder-606" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span>“Both poor diet and poor sleep increase the risk of several public health conditions. As what we eat is so important for our health, we thought it would be interesting to investigate whether some of the health effects of different diets could involve changes to our sleep. In this context, so-called intervention studies have so far been lacking; studies designed to allow the mechanistic effect of different diets on sleep to be isolated,” says Jonathan Cedernaes, Physician and Associate Professor in Medical Cell Biology at Uppsala University.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">Previous epidemiological studies have shown that diets with greater sugar content, for example, are linked to poorer sleep. Yet sleep is an interplay of different physiological states, as Cedernaes explains: “For example, deep sleep can be affected by what we eat. But no study had previously investigated what happens if we consume an unhealthy diet and then compared it to the quality of sleep after that same person follows a healthy diet. What is exciting in this context is that sleep is very dynamic. Our sleep consists of different stages with different functions, such as deep sleep which regulates hormonal release, for example.”</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">He adds, “Furthermore, each sleep stage is hallmarked by different types of electrical activity in the brain. This regulates aspects such as how restorative sleep is, and differs across different brain regions. But the depth or integrity of the sleep stages can also be negatively affected by factors such as insomnia and aging. Previously, it has not been investigated whether similar changes in our sleep stages can occur after exposure to different diets.”</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">Each study session involved several days of monitoring in a sleep laboratory. Therefore, only 15 individuals were included in the study. A total of 15 healthy normal-weight young men participated in two sessions. Participants were first screened for aspects such as their sleep habits, which had to be normal and within the recommended range (an average of seven to nine hours of sleep per night).</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">In random order, the participants were given both a healthier diet and an unhealthier diet. The two diets contained the same number of calories, adjusted to each individual’s daily requirements. Among other things, the unhealthier diet contained a higher content of sugar and saturated fat and more processed food items. The meals of each diet had to be consumed at individually adjusted times, which were matched across the two dietary conditions. Each diet was consumed for a week, while the participants’ sleep, activity, and meal schedules were monitored at an individual level.</span></p><p></p><span data-inserter-version="2" id="ezoic-pub-ad-placeholder-112" style="background-color: white; border: 0px; font-family: Public Sans; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">After each diet, the participants were examined in a sleep laboratory. There, they were first allowed to sleep a normal night, while their brain activity was measured to monitor their sleep. The participants were then kept awake in the sleep laboratory, before being allowed to catch up on sleep. Their sleep was recorded in this case, too.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">“What we saw was that the participants slept for the same amount of time when they consumed the two diets. This was the case both while they were following the diets, as well as after they had switched to another, identical diet. In addition, across the two diets, the participants spent the same amount of time in the different sleep stages. But we were particularly interested in investigating the properties of their deep sleep,” explains Cedernaes.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">He continues, “Specifically, we looked at slow-wave activity, a measure that can reflect how restorative deep sleep is. Intriguingly, we saw that deep sleep exhibited less slow-wave activity when the participants had eaten junk food, compared with the consumption of healthier food. This effect also lasted into a second night, once we had switched the participants to an identical diet. Essentially, the unhealthy diet resulted in shallower deep sleep. Of note, similar changes in sleep occur with aging and in conditions such as insomnia. It can be hypothesized, from a sleep perspective, that greater importance should potentially be attached to diet in such conditions.”</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">The researchers do not currently know how long-lasting the sleep effects of the unhealthier diet may be. The study did not investigate whether shallower deep sleep may alter functions that are regulated by deep sleep, for example.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">“It would also be interesting to conduct functional tests, for example, to see whether memory function can be affected. This is regulated to a large extent by sleep. And it would be equally interesting to understand how long-lasting the observed effects may be. Currently, we do not know which substances in the unhealthier diet worsened the depth of deep sleep. As in our case, unhealthy diets often contain both higher proportions of saturated fat and sugar and a lower proportion of dietary fiber,” states Cedernaes.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">“It would be interesting to investigate whether there is a particular molecular factor that plays a greater role. Our dietary intervention was also quite short, and both the sugar and fat content could have been higher. It is possible that an even unhealthier diet would have had more pronounced effects on sleep,” notes Cedernaes.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">Reference: “Exposure to a more unhealthy diet impacts sleep microstructure during normal sleep and recovery sleep: A randomized trial” by Luiz Eduardo Mateus Brandão, Alexandru Popa, Erasmus Cedernaes, Christopher Cedernaes, Lauri Lampola and Jonathan Cedernaes, 28 May 2023, <em style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Obesity</em>.<br /><a href="https://doi.org/10.1002/oby.23787" style="border: 0px; color: #005a8c; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: 600; line-height: inherit; margin: 0px; padding: 0px; text-decoration-line: none; transition: all 0.5s ease 0s; vertical-align: baseline;">DOI: 10.1002/oby.23787</a></span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">The study was funded by the Swedish Diabetes Foundation, the Forte – Swedish Research Council for Health, Working Life and Welfare, the Swedish Society for Medical Research (SSMF), Göran Gustafsson’s Foundation, and the Swedish Brain Foundation (Hjärnfonden).</span></p>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-31817323729115450802023-06-28T02:55:00.007-07:002023-06-28T03:21:22.922-07:00What Is Best for Weight Loss According to Science: Intermittent Fasting vs. Calorie Counting<p><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: white; font-style: inherit; font-variant-caps: inherit; font-variant-ligatures: inherit;">A study by the University of Illinois Chicago found that time-restricted eating (intermittent fasting) led to similar weight loss and improved </span><span aria-describedby="tt" class="glossaryLink" data-cmtooltip="<div class=glossaryItemTitle>insulin</div><div class=glossaryItemBody>Insulin is a hormone that regulates the level of glucose (sugar) in the blood. It is produced by the pancreas and released into the bloodstream when the level of glucose in the blood rises, such as after a meal. Insulin helps to transport glucose from the bloodstream into the cells, where it can be used for energy or stored for later use. Insulin also helps to regulate the metabolism of fat and protein. In individuals with diabetes, their body doesn&#039;t produce enough insulin or doesn&#039;t respond properly to insulin, leading to high blood sugar levels, which can lead to serious health problems if left untreated.</div>" data-gt-translate-attributes="[{"attribute":"data-cmtooltip", "format":"html"}]" style="background-color: white; border-bottom-color: rgb(0, 0, 0); border-bottom-style: dotted; border-image: initial; border-left-color: initial; border-left-style: initial; border-right-color: initial; border-right-style: initial; border-top-color: initial; border-top-style: initial; border-width: 0px 0px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">insulin</span><span style="background-color: white; font-style: inherit; font-variant-caps: inherit; font-variant-ligatures: inherit;"> sensitivity as traditional calorie restriction among adults with obesity. Participants in the time-restricted eating group ate fewer calories and lost more weight over a year compared to those who made no changes to their eating habits. Further research is needed to understand individual responses to each dietary intervention.</span></span></p><p><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: white; font-style: inherit; font-variant-caps: inherit; font-variant-ligatures: inherit;"><br /></span></span></p><p><span style="font-family: Public Sans; font-size: medium;"></span></p><div style="text-align: center;"><span style="font-family: Public Sans; font-size: medium;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjO2kaAGRIVhwWILsv-TFMZC8Ht9kWFRc0cnYBdnHirvUtBItkc5I-CvjS3djk7btDltsEtOcMaAwsOHfc_QVs9SB5WS_Zb31CNa1OfLzNDl4CFyCzRGXmWf08ObLKP0pBnKYzYDBeW710HDLFmRz5ZN10nfUzLp6w4oxKJk-UGN7O26u0RzuJ-1K3fTzE/s1440/intermittent-fasting-equals-calorie-counting-for-weight-loss-1440x810.jpg"><img border="0" data-original-height="810" data-original-width="1440" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjO2kaAGRIVhwWILsv-TFMZC8Ht9kWFRc0cnYBdnHirvUtBItkc5I-CvjS3djk7btDltsEtOcMaAwsOHfc_QVs9SB5WS_Zb31CNa1OfLzNDl4CFyCzRGXmWf08ObLKP0pBnKYzYDBeW710HDLFmRz5ZN10nfUzLp6w4oxKJk-UGN7O26u0RzuJ-1K3fTzE/s16000/intermittent-fasting-equals-calorie-counting-for-weight-loss-1440x810.jpg" /></a></span></div><span style="font-family: Public Sans; font-size: medium;"><span style="background-color: white; font-style: inherit; font-variant-caps: inherit; font-variant-ligatures: inherit;"><br /></span></span><p></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans; font-size: medium;"><span class="ezoic-adpicker-ad" id="ezoic-pub-ad-placeholder-170" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span>A small randomized controlled trial found that time-restricted eating, also known as intermittent fasting, produced similar weight loss results to traditional calorie counting in a racially diverse population of adults with obesity. The study also showed that participants who engaged in 8-hour time-restricted eating had improved insulin sensitivity compared to those in the control group who ate their calories any time over 10 or more hours a day. The study is published in the <em style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Annals of Internal Medicine.</em></span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans; font-size: medium;">Obesity is a major health issue. Many traditional weight loss diets involve counting calories, which can be cumbersome and difficult to do well. Time-restricted eating, without calorie counting, has become a popular weight loss strategy because it is simple to do. Whether it’s effective in producing weight loss, especially beyond the short term, is unclear.</span></p><div id="ezwrap_medianet_queue_0" style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><div id="974871025" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></div></div><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans; font-size: medium;"><span class="ezoic-adpicker-ad" id="ezoic-pub-ad-placeholder-606" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span>Researchers from the University of Illinois Chicago studied 90 adults with obesity from the Greater Chicago area to determine whether intermittent fasting or calorie-restricted eating would be more effective for weight control and cardiometabolic risk reduction.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans; font-size: medium;">Participants were randomly assigned to 1 of 3 groups: 8-hour time-restricted eating (eating from noon to 8:00 p.m. only, without calorie counting); calorie restriction (reduce 25% of their calories daily), or no change in calorie consumption, with eating taking place over 10 hours or more throughout the day. Both the time-restricted eating and calorie-restriction groups met regularly with a dietician. Participants were not blinded.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans; font-size: medium;">The authors found that participants who engaged in time-restricted eating ate 425 fewer calories per day than the control group and lost about 10 more pounds than the control group after one year. The calorie-restricted group ate 405 fewer calories per day and lost about 12 more pounds after one year. Participants showed high adherence to both interventions.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans; font-size: medium;">The authors of an accompanying editorial from the Anschutz Health and Wellness Center and Division of General Internal Medicine, University of Colorado School of Medicine say that access to dieticians likely helped participants in the restricted eating group make healthier food choices.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans; font-size: medium;">They believe the results of this study can help guide clinical decision-making partially by taking individual preferences into consideration, rather than just choosing a diet that may be more effective. They emphasize that the results of this study highlight the substantial individual variability in weight loss using these interventions, and that further research is needed to determine who would most benefit from each of these interventions.<span class="ezoic-adpicker-ad" id="ezoic-pub-ad-placeholder-608" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans; font-size: medium;">References:</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans; font-size: medium;">“Summary for Patients: Time-Restricted Eating Without Calorie Counting for Weight Loss” 27 June 2023, <em style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Annals of Internal Medicine</em>.<br /><a href="https://doi.org/10.7326/P23-0003" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: 600; line-height: inherit; margin: 0px; padding: 0px; text-decoration-line: none; transition: all 0.5s ease 0s; vertical-align: baseline;">DOI: 10.7326/P23-0003</a></span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans; font-size: medium;">“Time-Restricted Eating Without Calorie Counting for Weight Loss in a Racially Diverse Population: A Randomized Controlled Trial” by Shuhao Lin, MS, RD, Sofia Cienfuegos, PhD, Mark Ezpeleta, PhD, Kelsey Gabel, PhD, RD, Vasiliki Pavlou, MS, RD, Andrea Mulas, MS, RD, Kaitie Chakos, MS, RD, Mara McStay, MS, RD, Jackie Wu, MS, RD, Lisa Tussing-Humphreys, PhD, RD, Shaina J. Alexandria, PhD, Julienne Sanchez, MD, Terry Unterman, MD and Krista A. Varady, PhD, 27 June 2023, <em style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Annals of Internal Medicine</em>.<br /><a href="https://doi.org/10.7326/M23-0052" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: 600; line-height: inherit; margin: 0px; padding: 0px; text-decoration-line: none; transition: all 0.5s ease 0s; vertical-align: baseline;">DOI: 10.7326/M23-0052</a></span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans; font-size: medium;">“Time-Restricted Eating for Treatment of Obesity? The Devil Is in the (Counseling) Details” by Adam H. Gilden, MD, MSCE and Victoria A. Catenacci, MD, 27 June 2023, <em style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Annals of Internal Medicine</em>.<br /><a href="https://doi.org/10.7326/M23-1396" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: 600; line-height: inherit; margin: 0px; padding: 0px; text-decoration-line: none; transition: all 0.5s ease 0s; vertical-align: baseline;">DOI: 10.7326/M23-1396</a></span></p>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-38321153638610353692023-06-28T02:54:00.006-07:002023-06-28T03:22:27.512-07:00What Your Body Fat Type Says About Your Health<p><span style="background-color: white; font-family: Public Sans; font-size: 16px;">Although we often think of fat as something unwelcome, it has remarkable significance in our bodies. Fat tissue not only releases hormones that regulate metabolism and appetite but also has a surprising influence over insulin sensitivity. But beware, excessive calorie consumption can lead to the expansion and multiplication of fat cells, fueling chronic inflammation and disrupting healthy metabolism. Unravel its secrets with us and seize control of your well-being.</span></p><div class="e599d42b92530cddc130" style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; font-size: 16px; margin: 0px; padding: 0px;"><h3 style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; font-size: 20px; line-height: 28px; margin: 24px 0px 8px; padding: 0px; text-align: center;"><span style="font-family: Public Sans;">Why body fat is healthy</span></h3></div><div class="e599d42b92530cddc130" style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; font-size: 16px; margin: 0px; padding: 0px;"><p style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; margin: 0px 0px 8px; padding: 0px;"><span style="font-family: Public Sans;">Beyond its unwelcome appearance in problem areas like our bellies and thighs, fat is very important for our bodies to function. Fat tissue not only releases hormones that regulate metabolism and appetite but also impacts insulin sensitivity. In fact, fat tissue contains <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777665/#:~:text=Expansion%20of%20adipose%20tissue%20mass,cells%20in%20key%20metabolic%20tissues." rel="noopener noreferrer nofollow" style="-webkit-tap-highlight-color: transparent; background-color: transparent; box-sizing: border-box; line-height: 16px; margin: 0px; padding: 0px; text-decoration-line: none;" target="_blank">immune cells</a> that impact inflammation, both soothing it and starting it.<br style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; margin: 0px; padding: 0px;" /><br style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; margin: 0px; padding: 0px;" />But beware, excessive calorie consumption can lead to excess production of fat cells, creating chronic inflammation and disrupting your healthy <a href="https://karger.com/jin/article/14/1/4/824270/Innate-Immune-Cells-in-the-Adipose-Tissue-in#:~:text=Innate%20immune%20cells%20present%20in,6%2C%2026%2D28%5D." rel="noopener noreferrer nofollow" style="-webkit-tap-highlight-color: transparent; background-color: transparent; box-sizing: border-box; line-height: 16px; margin: 0px; padding: 0px; text-decoration-line: none;" target="_blank">metabolism</a>.</span></p></div><div class="e599d42b92530cddc130" style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; font-size: 16px; margin: 0px; padding: 0px;"><h3 style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; font-size: 20px; line-height: 28px; margin: 24px 0px 8px; padding: 0px; text-align: center;"><span style="font-family: Public Sans;">Abdomen fat</span></h3></div><div class="fe475c3f28885ceec1f1" style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; font-size: 16px; margin: 0px 0px 16px; padding: 0px;" tabindex="-1"><div data-test-id="article-image-4" style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; margin: 0px; padding: 0px;"><picture class="b10992b7e7307cb7c32f" style="-webkit-tap-highlight-color: transparent; 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background-color: white; box-sizing: border-box; font-size: 16px; margin: 0px; padding: 0px;"><p style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; margin: 0px 0px 8px; padding: 0px;"><span style="font-family: Public Sans;">This is one of the most common types of body fat, and is known as <a href="https://www.health.harvard.edu/staying-healthy/abdominal-fat-and-what-to-do-about-it#:~:text=Fat%20accumulated%20in%20the%20lower,factors%2C%20including%20heredity%20and%20hormones." rel="noopener noreferrer nofollow" style="-webkit-tap-highlight-color: transparent; background-color: transparent; box-sizing: border-box; line-height: 16px; margin: 0px; padding: 0px; text-decoration-line: none;" target="_blank">visceral fat</a>. This type of fat is internal and packs itself around our vital organs in our body. We start to notice this fat when we eat too many calories and don’t do enough physical exercise.<br style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; margin: 0px; padding: 0px;" /><br style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; margin: 0px; padding: 0px;" />It can be a sign of a low metabolism or that you have a hormonal imbalance. For women, it is common for the body to change where it stores fat, particularly as we age. After menopause our muscles decrease and women’s fat increases, which may lead to fat being stored around the tummy area. As women age we are more likely to get visceral fat in our tummy, even if we don’t put on extra weight.</span></p></div><div class="e599d42b92530cddc130" style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; font-size: 16px; margin: 0px; padding: 0px;"><h3 style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; font-size: 20px; line-height: 28px; margin: 24px 0px 8px; padding: 0px; text-align: center;"><span style="font-family: Public Sans;">Upper arm fat</span></h3></div><div class="fe475c3f28885ceec1f1" style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; font-size: 16px; margin: 0px 0px 16px; padding: 0px;" tabindex="-1"><div data-test-id="article-image-8" style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; margin: 0px; padding: 0px;"><picture class="b10992b7e7307cb7c32f" style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; display: flex; margin: 0px; padding: 0px;"><source srcset="https://wl-brightside.cf.tsp.li/resize/728x/webp/676/afb/0d8bd057e4b54049c3c66ee22c.jpg.webp" style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; margin: 0px; padding: 0px;" type="image/webp"></source><img alt="What Your Body Fat Type Is Telling You About Your Health" class="e33ce0f82f0e7404cc63" height="640" id="image27873672" loading="lazy" src="https://wl-brightside.cf.tsp.li/resize/728x/jpg/676/afb/0d8bd057e4b54049c3c66ee22c.jpg" style="-webkit-tap-highlight-color: transparent; background-color: #f6f6f8; border-style: none; box-sizing: border-box; height: auto; margin: 0px; max-width: 100%; padding: 0px; width: 728px;" width="728" /></picture></div></div><div class="e599d42b92530cddc130" style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; font-size: 16px; margin: 0px; padding: 0px;"><p style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; margin: 0px 0px 8px; padding: 0px;"><span style="font-family: Public Sans;">If you start to notice a disproportionate amount of <a href="https://www.amaris-b.com/blog/why-is-arm-fat-a-much-bigger-problem-in-women-than-in-men" rel="noopener noreferrer nofollow" style="-webkit-tap-highlight-color: transparent; background-color: transparent; box-sizing: border-box; line-height: 16px; margin: 0px; padding: 0px; text-decoration-line: none;" target="_blank">fat collection</a> in your upper arms, then it could be because of hormonal changes in your body. For instance, if you’re taking any kind of hormone medication that changes your hormone levels, then you may start to notice more fat production in your upper arms.<br style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; margin: 0px; padding: 0px;" /><br style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; margin: 0px; padding: 0px;" />Actually, women are also more likely to develop arm fat than men. For instance, it is very common for women experiencing menopause to gain weight on their upper arms as their testosterone levels drop.</span></p></div><div class="e599d42b92530cddc130" style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; font-size: 16px; margin: 0px; padding: 0px;"><h3 style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; font-size: 20px; line-height: 28px; margin: 24px 0px 8px; padding: 0px; text-align: center;"><span style="font-family: Public Sans;">Hips and sides</span></h3></div><div class="fe475c3f28885ceec1f1" style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; font-size: 16px; margin: 0px 0px 16px; padding: 0px;" tabindex="-1"><div data-test-id="article-image-12" style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; margin: 0px; padding: 0px;"><picture class="b10992b7e7307cb7c32f" style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; 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background-color: white; box-sizing: border-box; font-size: 16px; margin: 0px; padding: 0px;"><p style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; margin: 0px 0px 8px; padding: 0px;"><span style="font-family: Public Sans;">It is known to be a storage center for fat, especially for women. This causes what’s known as love handles, and the main cause is likely to be heredity, as well as too much gluten and milk. And of course, lack of physical activity can contribute to more fat being stored here. Also, if you are taking <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583809/" rel="noopener noreferrer nofollow" style="-webkit-tap-highlight-color: transparent; background-color: transparent; box-sizing: border-box; line-height: 16px; margin: 0px; padding: 0px; text-decoration-line: none;" target="_blank">Estrogen</a> based medication (such as a contraceptive pill), it is common to produce more fat in these areas.</span></p></div><div class="e599d42b92530cddc130" style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; font-size: 16px; margin: 0px; padding: 0px;"><h3 style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; font-size: 20px; line-height: 28px; margin: 24px 0px 8px; padding: 0px; text-align: center;"><span style="font-family: Public Sans;">Lower back and waist</span></h3></div><div class="fe475c3f28885ceec1f1" style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; font-size: 16px; margin: 0px 0px 16px; padding: 0px;" tabindex="-1"><div data-test-id="article-image-15" style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; margin: 0px; padding: 0px;"><picture class="b10992b7e7307cb7c32f" style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; display: flex; margin: 0px; padding: 0px;"><source srcset="https://wl-brightside.cf.tsp.li/resize/728x/webp/49b/c32/07a23c5b56a4835e91bae9163a.jpg.webp" style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; margin: 0px; padding: 0px;" type="image/webp"></source><img alt="What Your Body Fat Type Is Telling You About Your Health" class="e33ce0f82f0e7404cc63" height="601" id="image27873674" loading="lazy" src="https://wl-brightside.cf.tsp.li/resize/728x/jpg/49b/c32/07a23c5b56a4835e91bae9163a.jpg" style="-webkit-tap-highlight-color: transparent; background-color: #f6f6f8; border-style: none; box-sizing: border-box; height: auto; margin: 0px; max-width: 100%; padding: 0px; width: 728px;" width="728" /></picture></div></div><div class="e599d42b92530cddc130" style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; font-size: 16px; margin: 0px; padding: 0px;"><p style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; margin: 0px 0px 8px; padding: 0px;"><span style="font-family: Public Sans;">Low protein-rich diets are often the culprit for fat production in this area. Regularly eating processed foods, refined carbohydrates, and sugary drinks on top of not exercising frequently can lead to <a href="https://www.tahoewomenscare.com/blog/why-stubborn-fat-accumulates-on-your-belly-thighs-and-buttocks#:~:text=An%20unhealthy%20diet%20can%20result,fat%20that%27s%20hard%20to%20lose." rel="noopener noreferrer nofollow" style="-webkit-tap-highlight-color: transparent; background-color: transparent; box-sizing: border-box; line-height: 16px; margin: 0px; padding: 0px; text-decoration-line: none;" target="_blank">excess</a> fat storage in the lower back and waist. This fat type is not only common for women, but also can often be found in men.</span></p></div><div class="e599d42b92530cddc130" style="-webkit-tap-highlight-color: transparent; background-color: white; box-sizing: border-box; font-size: 16px; margin: 0px; padding: 0px;"><p style="-webkit-tap-highlight-color: transparent; box-sizing: border-box; margin: 0px 0px 8px; padding: 0px;"><span style="font-family: Public Sans;">Our stomachs don’t only grow because of excess fat collection, there can be other reasons for a larger stomach. One of these reasons is the uncomfortable occurrence of bloating, which can easily be managed with a few key steps, giving you a <a href="https://brightside.me/inspiration-health/how-to-reduce-bloating-812194/" style="-webkit-tap-highlight-color: transparent; background-color: transparent; box-sizing: border-box; line-height: 16px; margin: 0px; padding: 0px; text-decoration-line: none;" target="_blank">naturally</a> flatter stomach.</span></p></div>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-54345837551581293352023-05-22T00:52:00.001-07:002023-05-22T00:53:54.594-07:00Sun Bathing: The Paradoxical Overdose of Vitamin D<p><img alt="Intense Sunshine Illustration" class="aligncenter size-large wp-image-279724" decoding="async" ezimgfmt="rs rscb2 src ng ngcb2 srcset" fetchpriority="high" height="583" importance="high" loading="eager" sizes="" src="https://scitechdaily.com/images/Intense-Sunshine-Illustration.jpg?ezimgfmt=ng%3Awebp%2Fngcb2%2Frs%3Adevice%2Frscb2-1" srcset="" style="border: 0px; clear: both; display: block; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; height: auto; line-height: inherit; margin: 1.25rem auto; max-width: 100%; padding: 0px; vertical-align: bottom;" width="777" /></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;"><span class="ezoic-adpicker-ad" id="ezoic-pub-ad-placeholder-170" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span>Vitamin D, colloquially known as the “Sunshine Vitamin,” is renowned for its crucial role in maintaining optimal health. Our bodies naturally produce vitamin D when our skin is exposed to sunlight. It is also available through diet and supplementation. The sunshine vitamin assists in various physiological processes, including calcium absorption for healthy bones and teeth, as well as immune system support. However, what happens when we ‘overdose’ on this vital nutrient? Can you indeed have too much of a good thing?</span></p><span class="ezoic-autoinsert-video ezoic-under_first_paragraph" style="background-color: white; border: 0px; font-family: Public Sans; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">The concept of getting too much vitamin D might seem bizarre. After all, reports of vitamin D deficiency far outstrip cases of its excess. Still, vitamin D toxicity, or hypervitaminosis D, is a genuine, albeit rare, condition that poses significant health risks. It is primarily caused by excessive consumption of vitamin D supplements, and not by diet or sun exposure.</span></p><div id="ezwrap_medianet_queue_0" style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><div id="974871025" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></div></div><div class="wp-caption aligncenter" id="attachment_72888" style="background-color: white; border: 0px; clear: both; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 1.25rem auto; max-width: 100%; padding: 0px; vertical-align: baseline; width: 787px;"><span style="font-family: Public Sans;"><img alt="Food Containing Vitamin D" aria-describedby="caption-attachment-72888" class="size-large wp-image-72888 ezlazyloaded" data-ezsrc="https://scitechdaily.com/images/Food-Containing-Vitamin-D-777x518.jpg?ezimgfmt=rs:727x484/rscb2/ng:webp/ngcb2" data-ezsrcset="https://scitechdaily.com/images/Food-Containing-Vitamin-D-777x518.jpg?ezimgfmt=ng:webp/ngcb2 777w,https://scitechdaily.com/images/Food-Containing-Vitamin-D-400x267.jpg?ezimgfmt=ng:webp/ngcb2 400w,https://scitechdaily.com/images/Food-Containing-Vitamin-D-768x512.jpg?ezimgfmt=ng:webp/ngcb2 768w,https://scitechdaily.com/images/Food-Containing-Vitamin-D-1536x1024.jpg?ezimgfmt=ng:webp/ngcb2 1536w,https://scitechdaily.com/images/Food-Containing-Vitamin-D.jpg?ezimgfmt=ng:webp/ngcb2 2000w" decoding="async" ezimgfmt="rs rscb2 src ng ngcb2 srcset" ezoid="0.9586007514815551" height="518" loading="lazy" sizes="(max-width: 777px) 100vw, 777px" src="https://scitechdaily.com/images/Food-Containing-Vitamin-D-777x518.jpg?ezimgfmt=rs:727x484/rscb2/ng:webp/ngcb2" srcset="https://scitechdaily.com/images/Food-Containing-Vitamin-D-777x518.jpg?ezimgfmt=ng:webp/ngcb2 777w,https://scitechdaily.com/images/Food-Containing-Vitamin-D-400x267.jpg?ezimgfmt=ng:webp/ngcb2 400w,https://scitechdaily.com/images/Food-Containing-Vitamin-D-768x512.jpg?ezimgfmt=ng:webp/ngcb2 768w,https://scitechdaily.com/images/Food-Containing-Vitamin-D-1536x1024.jpg?ezimgfmt=ng:webp/ngcb2 1536w,https://scitechdaily.com/images/Food-Containing-Vitamin-D.jpg?ezimgfmt=ng:webp/ngcb2 2000w" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; height: auto; line-height: inherit; margin: 0px; max-width: 100%; padding: 0px; vertical-align: bottom;" width="777" /></span><p class="wp-caption-text" id="caption-attachment-72888" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 0.875rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: 1.4; margin: 0.3125rem 0px 0px; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">Food sources of vitamin D include oily fish, including salmon, mackerel, and sardines, as well as egg yolks and fortified milk.</span></p><span class="ezoic-autoinsert-video ezoic-under_second_paragraph" style="border: 0px; font-family: Public Sans; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></div><h4 style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 1.25rem; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: 1.3; margin: 0px 0px 1.25rem; padding: 0px; transition: all 0.5s ease 0s; vertical-align: baseline;"><span style="color: black; font-family: Public Sans;"><b>The Culprit Behind Vitamin D Overdose</b></span></h4><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">Sunbathing and food sources, contrary to popular belief, are not typically responsible for vitamin D toxicity. The body has an inbuilt mechanism to prevent the overproduction of vitamin D from sunlight. Similarly, it’s almost impossible to consume too much vitamin D through food alone, as very few foods naturally contain it.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">Vitamin D supplements, on the other hand, can cause levels to skyrocket if taken in excess. In the U.S., the daily recommended dietary allowance for adults is between 600 and 800 international units (IU) of vitamin D. Toxicity is generally observed when taking 10,000 to 60,000 IU/day for a few months or longer, or as a single very large dose.</span></p><hr style="background-color: white; font-size: 17.008px;" /><h4 style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 1.25rem; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; font-weight: 400; line-height: 1.3; margin: 0px 0px 1.25rem; padding: 0px; text-align: center; transition: all 0.5s ease 0s; vertical-align: baseline;"><span style="color: black; font-family: Public Sans;">Vitamin D Recommended Daily Intake*</span></h4><table border="1" style="background-color: white; border-collapse: collapse; border-spacing: 0px; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline; width: 726.577px;"><thead style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><tr style="background-color: #eae9e8; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><th scope="col" style="background: rgb(0, 90, 140); border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0.625rem; vertical-align: baseline;"><span style="font-family: Public Sans;">Life Stage</span></th><th scope="col" style="background: rgb(0, 90, 140); border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0.625rem; vertical-align: baseline;"><span style="font-family: Public Sans;">Recommended Amount</span></th></tr></thead><tbody style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><tr style="background-color: #eae9e8; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><td scope="row" style="border-bottom-color: rgb(235, 235, 235); border-bottom-style: solid; border-image: initial; border-left-color: rgb(235, 235, 235); border-left-style: solid; border-right-color: rgb(235, 235, 235); border-right-style: solid; border-top-color: initial; border-top-style: initial; border-width: 0px 1px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 0.75rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0.625rem; text-align: center; vertical-align: middle;"><span style="font-family: Public Sans;">Birth to 12 months</span></td><td align="right" style="border-bottom-color: rgb(235, 235, 235); border-bottom-style: solid; border-image: initial; border-left-color: rgb(235, 235, 235); border-left-style: solid; border-right-color: rgb(235, 235, 235); border-right-style: solid; border-top-color: initial; border-top-style: initial; border-width: 0px 1px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 0.75rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0.625rem; text-align: center; vertical-align: middle;"><span style="font-family: Public Sans;">10 mcg (400 IU)</span></td></tr><tr style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><td scope="row" style="border-bottom-color: rgb(235, 235, 235); border-bottom-style: solid; border-image: initial; border-left-color: rgb(235, 235, 235); border-left-style: solid; border-right-color: rgb(235, 235, 235); border-right-style: solid; border-top-color: initial; border-top-style: initial; border-width: 0px 1px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 0.75rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0.625rem; text-align: center; vertical-align: middle;"><span style="font-family: Public Sans;">Children 1–13 years</span></td><td align="right" style="border-bottom-color: rgb(235, 235, 235); border-bottom-style: solid; border-image: initial; border-left-color: rgb(235, 235, 235); border-left-style: solid; border-right-color: rgb(235, 235, 235); border-right-style: solid; border-top-color: initial; border-top-style: initial; border-width: 0px 1px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 0.75rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0.625rem; text-align: center; vertical-align: middle;"><span style="font-family: Public Sans;">15 mcg (600 IU)</span></td></tr><tr style="background-color: #eae9e8; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><td scope="row" style="border-bottom-color: rgb(235, 235, 235); border-bottom-style: solid; border-image: initial; border-left-color: rgb(235, 235, 235); border-left-style: solid; border-right-color: rgb(235, 235, 235); border-right-style: solid; border-top-color: initial; border-top-style: initial; border-width: 0px 1px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 0.75rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0.625rem; text-align: center; vertical-align: middle;"><span style="font-family: Public Sans;">Teens 14–18 years</span></td><td align="right" style="border-bottom-color: rgb(235, 235, 235); border-bottom-style: solid; border-image: initial; border-left-color: rgb(235, 235, 235); border-left-style: solid; border-right-color: rgb(235, 235, 235); border-right-style: solid; border-top-color: initial; border-top-style: initial; border-width: 0px 1px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 0.75rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0.625rem; text-align: center; vertical-align: middle;"><span style="font-family: Public Sans;">15 mcg (600 IU)</span></td></tr><tr style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><td scope="row" style="border-bottom-color: rgb(235, 235, 235); border-bottom-style: solid; border-image: initial; border-left-color: rgb(235, 235, 235); border-left-style: solid; border-right-color: rgb(235, 235, 235); border-right-style: solid; border-top-color: initial; border-top-style: initial; border-width: 0px 1px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 0.75rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0.625rem; text-align: center; vertical-align: middle;"><span style="font-family: Public Sans;">Adults 19–70 years</span></td><td align="right" style="border-bottom-color: rgb(235, 235, 235); border-bottom-style: solid; border-image: initial; border-left-color: rgb(235, 235, 235); border-left-style: solid; border-right-color: rgb(235, 235, 235); border-right-style: solid; border-top-color: initial; border-top-style: initial; border-width: 0px 1px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 0.75rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0.625rem; text-align: center; vertical-align: middle;"><span style="font-family: Public Sans;">15 mcg (600 IU)</span></td></tr><tr style="background-color: #eae9e8; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><td scope="row" style="border-bottom-color: rgb(235, 235, 235); border-bottom-style: solid; border-image: initial; border-left-color: rgb(235, 235, 235); border-left-style: solid; border-right-color: rgb(235, 235, 235); border-right-style: solid; border-top-color: initial; border-top-style: initial; border-width: 0px 1px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 0.75rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0.625rem; text-align: center; vertical-align: middle;"><span style="font-family: Public Sans;">Adults 71 years and older</span></td><td align="right" style="border-bottom-color: rgb(235, 235, 235); border-bottom-style: solid; border-image: initial; border-left-color: rgb(235, 235, 235); border-left-style: solid; border-right-color: rgb(235, 235, 235); border-right-style: solid; border-top-color: initial; border-top-style: initial; border-width: 0px 1px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 0.75rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0.625rem; text-align: center; vertical-align: middle;"><span style="font-family: Public Sans;">20 mcg (800 IU)</span></td></tr><tr style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><td scope="row" style="border-bottom-color: rgb(235, 235, 235); border-bottom-style: solid; border-image: initial; border-left-color: rgb(235, 235, 235); border-left-style: solid; border-right-color: rgb(235, 235, 235); border-right-style: solid; border-top-color: initial; border-top-style: initial; border-width: 0px 1px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 0.75rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0.625rem; text-align: center; vertical-align: middle;"><span style="font-family: Public Sans;">Pregnant and breastfeeding teens and women</span></td><td align="right" style="border-bottom-color: rgb(235, 235, 235); border-bottom-style: solid; border-image: initial; border-left-color: rgb(235, 235, 235); border-left-style: solid; border-right-color: rgb(235, 235, 235); border-right-style: solid; border-top-color: initial; border-top-style: initial; border-width: 0px 1px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 0.75rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0.625rem; text-align: center; vertical-align: middle;"><span style="font-family: Public Sans;">15 mcg (600 IU)</span></td></tr></tbody></table><hr style="background-color: white; font-size: 17.008px;" /><h4 style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 1.25rem; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: 1.3; margin: 0px 0px 1.25rem; padding: 0px; transition: all 0.5s ease 0s; vertical-align: baseline;"><span style="color: black; font-family: Public Sans;"><b>The Unseen Impact of Vitamin D Overdose</b></span></h4><b><span class="ezoic-autoinsert-video ezoic-mid_content" style="background-color: white; border: 0px; font-family: Public Sans; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></b><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">The primary consequence of vitamin D toxicity is a buildup of calcium in your blood (hypercalcemia), which can cause nausea, vomiting, weakness, and frequent urination. Symptoms might progress to bone pain and kidney problems, such as the formation of calcium stones.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">Moreover, consistently high levels of vitamin D can lead to heart problems, such as irregular heartbeat and hypertension. It can also damage the kidneys and, in severe cases, cause kidney failure. Elevated calcium levels due to long-term vitamin D toxicity can result in vascular and tissue calcification, leading to heart attack and stroke.</span></p><h4 style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 1.25rem; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: 1.3; margin: 0px 0px 1.25rem; padding: 0px; transition: all 0.5s ease 0s; vertical-align: baseline;"><span style="color: black; font-family: Public Sans;"><b>Man Hospitalized After Losing 28 Pounds From ‘Overdosing’ on Vitamin D Supplements</b></span></h4><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">Last year, <a href="https://scitechdaily.com/doctors-warn-of-vitamin-d-supplement-overdosing-man-hospitalized-after-losing-28-pounds/" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: 600; line-height: inherit; margin: 0px; padding: 0px; text-decoration-line: none; transition: all 0.5s ease 0s; vertical-align: baseline;">doctors warned</a> in the journal <em style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">BMJ Case Reports</em> that ‘overdosing’ on vitamin D supplements is both possible and harmful after they treated a man who needed hospital admission for his excessive vitamin D intake. The patient, a middle-aged man, began having problems about a month after he began an intensive vitamin supplement regimen on the advice of a nutritional therapist. His symptoms included recurrent vomiting, nausea, leg cramps, abdominal pain, increased thirst, dry mouth, tinnitus, diarrhea, and weight loss.</span></p><h4 style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 1.25rem; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: 1.3; margin: 0px 0px 1.25rem; padding: 0px; transition: all 0.5s ease 0s; vertical-align: baseline;"><span style="color: black; font-family: Public Sans;"><b>Prevention is Better than Cure</b></span></h4><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">While vitamin D toxicity is rare, its implications are severe enough to warrant caution. If you’re taking a vitamin D supplement, make sure it does not exceed the recommended daily allowance unless instructed by a healthcare provider. Regular testing of vitamin D levels, especially for those on high-dose supplements, can prevent inadvertent toxicity.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">The balance, as always, is key. While ensuring sufficient vitamin D levels is crucial for bone health and immune function, going overboard can have undesired consequences. The sunshine vitamin, like all good things, is best enjoyed in moderation.</span></p><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="border: 0px; font-family: Public Sans; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: 900; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Learn More:</span></p><ul style="background-color: white; border: 0px; box-sizing: border-box; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; list-style: square; margin: 0px 0px 1.875rem 2.5rem; padding: 0px; vertical-align: baseline;"><li style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><a href="https://scitechdaily.com/scientists-debunk-common-vitamin-d-myths/" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: 600; line-height: inherit; margin: 0px; padding: 0px; text-decoration-line: none; transition: all 0.5s ease 0s; vertical-align: baseline;"><span style="color: black; font-family: Public Sans;">Scientists Debunk Common Vitamin D Myths</span></a></li><li style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><a href="https://scitechdaily.com/new-study-finds-that-vitamin-d-could-help-extend-your-life/" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: 600; line-height: inherit; margin: 0px; padding: 0px; text-decoration-line: none; transition: all 0.5s ease 0s; vertical-align: baseline;"><span style="color: black; font-family: Public Sans;">Study Finds That Vitamin D Could Help Extend Your Life</span></a></li><li style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><a href="https://scitechdaily.com/new-study-shows-taking-vitamin-d-supplements-could-help-prevent-dementia/" style="border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: 600; line-height: inherit; margin: 0px; padding: 0px; text-decoration-line: none; transition: all 0.5s ease 0s; vertical-align: baseline;"><span style="color: black; font-family: Public Sans;">Study Shows Vitamin D Supplements Could Help Prevent Dementia</span></a></li></ul><p style="background-color: white; border: 0px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: 17.008px; font-stretch: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; font-variation-settings: inherit; line-height: inherit; margin: 0px 0px 1.25rem; padding: 0px; vertical-align: baseline;"><span style="font-family: Public Sans;">*These are the average daily recommended amounts according to the U.S. <span aria-describedby="tt" class="glossaryLink" data-cmtooltip="<div class=glossaryItemTitle>National Institutes of Health</div><div class=glossaryItemBody>The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. Founded in 1887, it is a part of the U.S. Department of Health and Human Services. The NIH conducts its own scientific research through its Intramural Research Program (IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program. With 27 different institutes and centers under its umbrella, the NIH covers a broad spectrum of health-related research, including specific diseases, population health, clinical research, and fundamental biological processes. Its mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability.</div>" data-gt-translate-attributes="[{"attribute":"data-cmtooltip", "format":"html"}]" style="border-bottom-color: rgb(0, 0, 0); border-bottom-style: dotted; border-image: initial; border-left-color: initial; border-left-style: initial; border-right-color: initial; border-right-style: initial; border-top-color: initial; border-top-style: initial; border-width: 0px 0px 1px; font-feature-settings: inherit; font-kerning: inherit; font-optical-sizing: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-variation-settings: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">National Institutes of Health</span> (NIH) Office of Dietary Supplements (ODS).</span></p>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-44035217206561779312023-05-22T00:37:00.004-07:002023-05-22T00:41:55.124-07:00World Pre-eclampsia Day 2023<p><span style="font-family: Public Sans; font-size: medium;"></span></p><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Public Sans; font-size: medium;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg4VV6uaozFjwkzlg6h5ZunwB9zmRLBJTEcLOMaNQt3aFl4F1nO7iBuFLqLb3sUc0WEk_nhqs5ORJVFSSjCuWHU8pZVyO98NadGW2fYKcUjSJUTvQ3FoXHZ9mWnDeaH0G8MkScmzYmHDzmmuFTZhDYH4huWWi8RU__nRw__lKDbAE12GseFjZrkcpY0/s800/may-22-is-observed-as-world-preeclampsia-day.jpg" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="534" data-original-width="800" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg4VV6uaozFjwkzlg6h5ZunwB9zmRLBJTEcLOMaNQt3aFl4F1nO7iBuFLqLb3sUc0WEk_nhqs5ORJVFSSjCuWHU8pZVyO98NadGW2fYKcUjSJUTvQ3FoXHZ9mWnDeaH0G8MkScmzYmHDzmmuFTZhDYH4huWWi8RU__nRw__lKDbAE12GseFjZrkcpY0/s16000/may-22-is-observed-as-world-preeclampsia-day.jpg" /></a></span></div><span style="font-family: Public Sans; font-size: medium;"><b><br /></b></span><p></p><p><span style="font-family: Public Sans; font-size: medium;"><b>World Pre-eclampsia Day 2023:</b> World Pre-eclampsia Day is observed on the May 22 every year to spread awareness about one of the leading causes of maternal and infant mortality worldwide.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p><span style="font-family: Public Sans; font-size: medium;">Pre-eclampsia refers to the elevation of blood pressure equal to or more than 140/90 mm Hg and the presence of excessive protein in urine after the 20th week of pregnancy. It is one of the reasons why expectant mothers should not miss ante-natal check-ups (at least 4). Regularly monitoring blood pressure levels can aid in the early detection of this potentially life-threatening condition.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p><span style="font-family: Public Sans; font-size: medium;">While pre-eclampsia typically manifests after the 20th week of pregnancy, it can, in some cases, be identified earlier. Sudden weight gain, persistent headaches, elevated blood pressure, swelling of the hands and face, blurred vision, and abdominal pain serve as warning signs, indicating the need to promptly consult with an obstetrician. These proactive measures contribute to the early identification and management of this disorder.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p><span style="font-family: Public Sans; font-size: medium;">The American College of Obstetricians and Gynecologists (ACOG) classifies pre-eclampsia into non-severe and severe categories. Non-severe pre-eclampsia may progress to a severe state, where blood pressure levels soar to 160/110 mm Hg or higher. Severe pre-eclampsia is often accompanied by cerebral edema (swelling due to fluid retention) leading to headaches and visual disturbances caused by optic fundus changes. Abdominal pain may also be experienced. Laboratory reports may reveal elevated liver enzymes and serum creatinine, as well as increased protein excretion through urine, indicating renal involvement.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><h3 style="text-align: left;"><span style="font-family: Public Sans; font-size: large;">The following are the risk factors for pre-eclampsia:</span></h3><p><span style="font-family: Public Sans; font-size: medium;"><b>Primiparity:</b> First-time mothers, also called primigravidae, are at a higher risk for developing pre-eclampsia. Exposure to chorionic villi (small projections of the placenta that help exchange nutrients from the maternal blood to the foetus) for the first time can cause an increase in blood pressure.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><b>Age:</b> The chances of risk are higher if pregnancy is before 18 years or after 35 years of age.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><b>BMI:</b> A high Body Mass Index of more than 35 kg/m2 acts as a predisposing factor to preeclampsia.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><b>Multiple pregnancy: </b>When the womb of a female carries more than one foetus, most often resulting in identical or non-identical twins or even triplets, it is referred to as a multiple pregnancy, which can lead to pre-eclampsia.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><b>Maternal co-morbidities:</b> If the mothers suffer from any other medical health condition like diabetes, hypertension, or renal disease, they become more susceptible to this pregnancy complication.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><b>Family history:</b> A female having a family history of pre-eclampsia must be extra cautious, as genetics play a role in its evolution.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p><span style="font-family: Public Sans; font-size: medium;">The complications of this condition include abruptio placenta, where the placenta (responsible for exchanging gases and nutrients between the mother and the baby) gets separated from the uterine wall before birth. Acute renal failure, pleural effusion (excess fluid in the cavity outside the lungs) and laryngeal oedema can also be seen.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p><span style="font-family: Public Sans; font-size: medium;">Pre-eclampsia can be fatal not only to the mother but also to the baby, as it can lead to pre-term delivery, prematurity and sepsis. Functional changes in the placenta can place the foetus in jeopardy.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p><span style="font-family: Public Sans; font-size: medium;">It may also progress to seizures, stroke and, ultimately, death. Awareness and timely visits can help in preventing and managing pre-eclampsia.</span></p>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-61758293919958095202023-05-11T01:11:00.026-07:002023-05-11T01:38:05.215-07:00SuperBaby Born in Britain Using Genetic Material from Three People<p></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiD9Q_pUGWNEQllKoFbEY6E4yQt5qVb8rC0idrJOKARkCpHim2gjwthB_F0_p5yyQf8wjABS7Ur23yLzFbbajS2PU6h5CAk38CfuKGC0btQUBRlUoWQe1hP2aDUZ_lmBciwrN_05eajd1FhQnAYt8DAh78-X4yAUULz5sAo6I_gSsbyeC-KPec7yAn0/s739/images%20(22).jpeg" style="margin-left: 1em; margin-right: 1em;"><span style="font-family: Public Sans;"><img border="0" data-original-height="415" data-original-width="739" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiD9Q_pUGWNEQllKoFbEY6E4yQt5qVb8rC0idrJOKARkCpHim2gjwthB_F0_p5yyQf8wjABS7Ur23yLzFbbajS2PU6h5CAk38CfuKGC0btQUBRlUoWQe1hP2aDUZ_lmBciwrN_05eajd1FhQnAYt8DAh78-X4yAUULz5sAo6I_gSsbyeC-KPec7yAn0/s16000/images%20(22).jpeg" /></span></a></div><span style="font-family: Public Sans;"><br /></span><p></p><p><span style="font-family: Public Sans;">दुनिया का पहला Superkid पैदा हो चुका है. सुपरपावर वाला. इस सुपरबेबी को किसी तरह की जेनेटिक बीमारी नहीं होगी. न ही कोई नुकसानदेह जेनेटिक म्यूटेशन. क्योंकि इस बच्चे में सिर्फ उसके माता-पिता का डीएनए नहीं है. बल्कि तीसरे व्यक्ति का भी डीएनए जोड़ा गया है. यह बच्चा पैदा किया गया है इंग्लैंड में. </span></p><p><span style="font-family: Public Sans;">इस बच्चे को पैदा करने के लिए तीन लोगों के डीएनए का इस्तेमाल किया गया. डीएनए की खासियत को बनाए रखने के लिए आईवीएफ तकनीक का इस्तेमाल किया गया. दावा किया गया है कि इस बच्चे को किसी भी तरह की ऐसी जेनेटिक बीमारी नहीं होगी, जिसका इलाज न किया जा सके. </span></p><p><span style="font-family: Public Sans;">जिस तकनीक से इस बच्चे को बनाया गया है, इसे माइटोकॉन्ड्रियल डोनेशन ट्रीटमेंट (MDT) कहते. इस बच्चे को पैदा करने के लिए स्वस्थ महिला के अंडे (Eggs) से ऊतक (Tissue) लेकर आईवीएफ भ्रूण तैयार किया गया है. यह भ्रूण जिस गर्भ में पला, उस महिला की जेनेटिक बीमारियों से वह सुरक्षित है. यानी इसे मां के शरीर में होने वाली बीमारियों से कोई असर नहीं होगा. न ही उसे ये बीमारियां होंगी. </span></p><p><span style="font-family: Public Sans;"><br /></span></p><h2 style="text-align: left;"><span style="font-family: Public Sans;">यह बच्चा असल में थ्री-पैरेंट बेबी है</span></h2><p><span style="font-family: Public Sans;">इस भ्रूण में बायोलॉजिकल माता-पिता के स्पर्म और एग्स के माइटोकॉन्ड्रिया (Mitochondria) को मिलाया गया है. माइटोकॉन्ड्रिया किसी भी कोशिका का पावर हाउस होता है. इस बच्चे के शरीर में माता-पिता के डीएनए के अलावा तीसरी महिला डोनर के जेनेटिक मटेरियल में से 37 जीन शामिल हैं. यानी यह बच्चा असल में थ्री-पैरेंट बेबी (Three-parent Baby) है. हालांकि, इस बच्चे के शरीर में 99.8 फीसदी डीएनए उसके मां-बाप का ही है.</span></p><p><span style="font-family: Public Sans;"><br /></span></p><h2 style="text-align: left;"><span style="font-family: Public Sans;">मां से ही बच्चे को मिलता है पावर हाउस</span></h2><p><span style="font-family: Public Sans;">माइटोकॉन्ड्रियल डोनेशन ट्रीटमेंट को MRT यानी माइटोकॉन्ड्रियल रीप्लेसमेंट ट्रीटमेंट भी कहते हैं. इस पद्धत्ति को विकसित और उसमें इंग्लैंड के डॉक्टरों ने किया है. इस बच्चे को इंग्लैंड के न्यूकैसल फर्टिलिटी सेंटर में पैदा कराया गया. मकसद यही था कि ऐसा बच्चा पैदा किया जाए, जिसमें माता-पिता की जेनेटिक बीमारियां ट्रांसफर न हों. आमतौर पर कोई भी इंसान अपनी मां से ही ज्यादातर माइटोकॉन्ड्रिया हासिल करता है. </span></p><p><span style="font-family: Public Sans;"><br /></span></p><h2 style="text-align: left;"><span style="font-family: Public Sans;">जेनेटिक बीमारियों से मुक्त रहेगा बच्चा</span></h2><p><span style="font-family: Public Sans;">इसलिए जो भी नुकसानदेह म्यूटेशन होते हैं, वो इन पावर हाउस में जमा रहते हैं. वो बाद में बच्चे की सेहत पर असर डालते हैं. जेनेटिक बीमारियों से जूझ रहीं महिलाओं को आमतौर पर प्राकृतिक तौर पर गर्भधारण करने में दिक्कत आती है. अगर कर भी लिया तो बच्चे की सेहत सही नहीं रहती. बड़े होने के साथ-साथ बच्चे गंभीर बीमारियों से जूझने लगते हैं. दुनिया में 6000 में एक बच्चा माइटोकॉन्ड्रियल बीमारियों से जूझता है. यानी गंभीर जेनेटिक बीमारियों से. </span></p><p><span style="font-family: Public Sans;"><br /></span></p><h2 style="text-align: left;"><span style="font-family: Public Sans;">माइटोकॉन्ड्रिया सही नहीं तो विकास गड़बड़</span></h2><p><span style="font-family: Public Sans;">आमतौर पर इंसानों के शरीर में हर कोशिका के केंद्र यानी न्यूक्लियस में 20 हजार जीन्स होते हैं. लेकिन हर न्यूक्लियस के चारों तरफ छोटे-छोटे बिंदुओं की तरह माइटोकॉन्ड्रिया होते हैं. जिनके अपने जीन्स होते हैं. अगर माइटोकॉन्ड्रिया सही से काम कर रहा है, तो वह कोशिका को ऊर्जा देता है. ताकि अंग बन सकें. अगर कोई जेनेटिक म्यूटेशन है तो माइटोकॉन्ड्रिया डैमेज हो जाता है. फिर वह ऊर्जा खत्म करता है. इसका असर दिमाग, दिल, मांसपेशियां और लिवर पर पड़ता है. इससे बच्चे का विकास सही नहीं होता. </span></p><p><span style="font-family: Public Sans;"><br /></span></p><h2 style="text-align: left;"><span style="font-family: Public Sans;">MDT तकनीक के लिए बदला गया था कानून</span></h2><p><span style="font-family: Public Sans;">एमडीटी तकनीक की शुरुआत के लिए इंग्लैंड की संसद ने 2015 में कानून में बदलाव किया था. दो साल बाद ही न्यूकैसल क्लीनिक इंग्लैंड का पहला ऐसा सेंटर बना, जिसके पास यह तकनीक इस्तेमाल करने का लाइसेंस था. फिर उसने ह्यूमन फर्टिलाइजेशन एंड एंब्रियोलॉजी अथॉरिटी से अप्रूवल लेकर प्रयोग को आगे बढ़ाया. अब इस क्लीनिक के डॉक्टरों ने इस सुपरकिड को पैदा करने की पूरी प्रक्रिया को सार्वजनिक कर दिया है. जिसमें बताया कि पांच से कम बच्चे इस तरह से पैदा किए गए हैं. लेकिन उनमें सुपरकिड वाली क्षमता कम है.</span></p><p><span style="font-family: Public Sans;"><br /></span></p><h2 style="text-align: left;"><span style="font-family: Public Sans;">MDT का प्रोसेस क्या होता है? </span></h2><p><span style="font-family: Public Sans;">सबसे पहले पिता का स्पर्म लेकर उसकी मदद से मां के एग्स को फर्टिलाइज किया गया. उसके बाद स्वस्थ महिला के एग्स से न्यूक्लियर जेनेटिक मटेरियल निकाला गया. फिर इसे माता-पिता के फर्टिलाइज एग्स से मिला दिया गया. इससे फर्टिलाइज एग्स में क्रोमोसोम्स की संख्या पूरी हो गई. अब इस एग में स्वस्थ महिला के माइटोकॉन्ड्रिया का वर्चस्व हो जाता है. क्योंकि वह सेहतमंद होता है. इसके बाद इसे भ्रूण में स्थापित कर दिया जाता है. </span></p><p><span style="font-family: Public Sans;"><br /></span></p><h2 style="text-align: left;"><span style="font-family: Public Sans;">ऐसा नहीं इस तकनीक में खतरा नहीं है</span></h2><p><span style="font-family: Public Sans;">ऐसा नहीं है कि इस तकनीक में खतरा नहीं है. एकदम है. अगर अनजाने में एग्स के अंदर अनचाहे माइटोकॉन्ड्रिया आ गए तो वो बच्चे की सेहत पर असर डाल सकते हैं. इससे सुपरकिड पैदा करने की पूरी प्रक्रिया पलट सकती है. बच्चा सेहतमंद होने के बजाय कमजोर या अविकसित हो सकता है. इसलिए इस प्रक्रिया को करते समय डॉक्टर बहुत ज्यादा ध्यान रखते हैं. </span></p>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-62721528096012777132023-04-26T01:05:00.007-07:002023-04-26T01:09:16.365-07:00Over 6,500 Rapes, Sexual Assaults in UK Hospitals Since 2019<p><span style="font-family: Public Sans; font-size: medium;"></span></p><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Public Sans; font-size: medium;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjklZ3lFqs5aWKh9B3fxGHQCGW_0uGdRIhsLZ7i6Q5tVKtGPxz57LmzDu1DWVSFbgUtBpun-TWg3dOHTymSCf9gclcXVuySIPWQmSGRhmxkpL1ARWs2Zd8dQ_o2aCxskwMRz6SBPvhZ3xJYPcjiiaDFXALPYT5nLogXb089ivDp1gcvnKrfpEeU2PvF/s712/NHS-hospital-sign-GettyImages-712_0.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="400" data-original-width="712" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjklZ3lFqs5aWKh9B3fxGHQCGW_0uGdRIhsLZ7i6Q5tVKtGPxz57LmzDu1DWVSFbgUtBpun-TWg3dOHTymSCf9gclcXVuySIPWQmSGRhmxkpL1ARWs2Zd8dQ_o2aCxskwMRz6SBPvhZ3xJYPcjiiaDFXALPYT5nLogXb089ivDp1gcvnKrfpEeU2PvF/s16000/NHS-hospital-sign-GettyImages-712_0.jpg" /></a></span></div><span style="font-family: Public Sans; font-size: medium;"><br /></span><p></p><p><span style="font-family: Public Sans; font-size: medium;"><span face=""Playfair Display", sans-serif" style="box-sizing: border-box; font-weight: 700;">London: </span><span face=""Playfair Display", sans-serif">Nurses working in UK hospitals will now be required to wear body cameras as part of the government’s efforts to crack down on sexual assaults in health institutions.</span></span></p><p style="box-sizing: border-box; font-feature-settings: normal; font-kerning: auto; font-optical-sizing: auto; font-stretch: normal; font-variant-alternates: normal; font-variant-east-asian: normal; font-variant-numeric: normal; font-variation-settings: normal; line-height: 24px; margin: 0px 0px 20px; padding: 0px;"><span style="font-family: Public Sans; font-size: medium;">The move comes after a shocking report emerged last week which revealed that there have been more than 6,500 reports of rape and sexual assault in hospitals since 2019.</span></p><p style="box-sizing: border-box; font-feature-settings: normal; font-kerning: auto; font-optical-sizing: auto; font-stretch: normal; font-variant-alternates: normal; font-variant-east-asian: normal; font-variant-numeric: normal; font-variation-settings: normal; line-height: 24px; margin: 0px 0px 20px; padding: 0px;"><span style="font-family: Public Sans; font-size: medium;">Health Secretary Steve Barclay introduced the rule of giving healthcare workers body-cams similar to those worn by paramedics and police.</span></p><p style="box-sizing: border-box; font-feature-settings: normal; font-kerning: auto; font-optical-sizing: auto; font-stretch: normal; font-variant-alternates: normal; font-variant-east-asian: normal; font-variant-numeric: normal; font-variation-settings: normal; line-height: 24px; margin: 0px 0px 20px; padding: 0px;"><span style="font-family: Public Sans; font-size: medium;">The Department of Health will work closely with National Health Service (NHS) to deploy the measure. Other steps that will be put in place to reduce the cases of sexual abuse in hospitals include AI data processors to improve prosecution rates and launching a national violence prevention hub, according to <em style="box-sizing: border-box;">The Telegraph</em>.</span></p><h3 style="box-sizing: border-box; font-feature-settings: normal; font-kerning: auto; font-optical-sizing: auto; font-stretch: normal; font-variant-alternates: normal; font-variant-east-asian: normal; font-variant-numeric: normal; font-variation-settings: normal; line-height: 24px; margin: 0px 0px 20px; padding: 0px; text-align: left;"><span style="box-sizing: border-box; font-family: Public Sans; font-size: large; font-weight: 700;">6,500 cases of sexual abuse in hospitals in 3 years</span></h3><p style="box-sizing: border-box; font-feature-settings: normal; font-kerning: auto; font-optical-sizing: auto; font-stretch: normal; font-variant-alternates: normal; font-variant-east-asian: normal; font-variant-numeric: normal; font-variation-settings: normal; line-height: 24px; margin: 0px 0px 20px; padding: 0px;"><span style="font-family: Public Sans; font-size: medium;">Last week, the Women’s Rights Network – a feminist group in the UK – published statistics revealing that sexual assaults take place in the country every week.</span></p><p style="box-sizing: border-box; font-feature-settings: normal; font-kerning: auto; font-optical-sizing: auto; font-stretch: normal; font-variant-alternates: normal; font-variant-east-asian: normal; font-variant-numeric: normal; font-variation-settings: normal; line-height: 24px; margin: 0px 0px 20px; padding: 0px;"><span style="font-family: Public Sans; font-size: medium;">In just the last three years, Britain reported 6,500 cases of rape and sexual assault in hospitals.</span></p><p style="box-sizing: border-box; font-feature-settings: normal; font-kerning: auto; font-optical-sizing: auto; font-stretch: normal; font-variant-alternates: normal; font-variant-east-asian: normal; font-variant-numeric: normal; font-variation-settings: normal; line-height: 24px; margin: 0px 0px 20px; padding: 0px;"><span style="font-family: Public Sans; font-size: medium;">Heather Binning, the founder of Women’s Rights said that the numbers are “just the tip of the iceberg.”</span></p><p style="box-sizing: border-box; font-feature-settings: normal; font-kerning: auto; font-optical-sizing: auto; font-stretch: normal; font-variant-alternates: normal; font-variant-east-asian: normal; font-variant-numeric: normal; font-variation-settings: normal; line-height: 24px; margin: 0px 0px 20px; padding: 0px;"><span style="font-size: medium;"><span style="font-family: Public Sans;">“Hospitals are places where everyone – patients, staff and visitors – should feel completely safe but rapes and violent assaults are taking place in hospitals every week,” she said. </span><span style="font-family: "Public Sans";">Binning added, “The figures show hospitals are just not safe places. They are almost a market for sexual offenders. It’s absolutely terrifying.”</span></span></p><p style="box-sizing: border-box; font-feature-settings: normal; font-kerning: auto; font-optical-sizing: auto; font-stretch: normal; font-variant-alternates: normal; font-variant-east-asian: normal; font-variant-numeric: normal; font-variation-settings: normal; line-height: 24px; margin: 0px 0px 20px; padding: 0px;"><span style="font-size: medium;"><span style="font-family: Public Sans;">Among the horrific crimes faced by patients, staff and visitors include gang rapes and assaults on children. </span><span style="font-family: "Public Sans";">What is more shocking is that only 4.1 per cent of the perpetrators involved in these cases have faced charges.</span></span></p><h3 style="box-sizing: border-box; font-feature-settings: normal; font-kerning: auto; font-optical-sizing: auto; font-stretch: normal; font-variant-alternates: normal; font-variant-east-asian: normal; font-variant-numeric: normal; font-variation-settings: normal; line-height: 24px; margin: 0px 0px 20px; padding: 0px; text-align: left;"><span style="box-sizing: border-box; font-family: Public Sans; font-size: large; font-weight: 700;">NHS vows to prevent attacks</span></h3><p style="box-sizing: border-box; font-feature-settings: normal; font-kerning: auto; font-optical-sizing: auto; font-stretch: normal; font-variant-alternates: normal; font-variant-east-asian: normal; font-variant-numeric: normal; font-variation-settings: normal; line-height: 24px; margin: 0px 0px 20px; padding: 0px;"><span style="font-family: Public Sans; font-size: medium;">The NHS director of sexual assault services commissioning, Kate Davies said, “We will work with the Government and other partners to ensure the NHS is a safe space for all staff and patients. Local services must not tolerate sexual misconduct, violence, harassment, or abuse – it is totally unacceptable.”</span></p><p style="box-sizing: border-box; font-feature-settings: normal; font-kerning: auto; font-optical-sizing: auto; font-stretch: normal; font-variant-alternates: normal; font-variant-east-asian: normal; font-variant-numeric: normal; font-variation-settings: normal; line-height: 24px; margin: 0px 0px 20px; padding: 0px;"><span style="font-family: Public Sans; font-size: medium;">“Preventing these attacks from occurring in the first place is a priority and we have a programme of work dedicated to this and have appointed our first national clinical lead to drive forward action – together we must do all we can to keep staff and patients in our services safe,” she added.</span></p><p style="box-sizing: border-box; font-feature-settings: normal; font-kerning: auto; font-optical-sizing: auto; font-stretch: normal; font-variant-alternates: normal; font-variant-east-asian: normal; font-variant-numeric: normal; font-variation-settings: normal; line-height: 24px; margin: 0px 0px 20px; padding: 0px;"><span style="font-family: Public Sans; font-size: medium;">She further said that it is of utmost importance that all NHS Trusts and Organisations must have “robust measures in place to ensure immediate action is taken in any cases reported to them.”</span></p>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.comtag:blogger.com,1999:blog-3029509242859721152.post-2709295929143815852023-04-26T00:35:00.009-07:002023-04-26T00:39:20.782-07:00Dogs Could Be 'Patient Zero' For Future Canine Influenza Outbreaks: Study<p></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhRrocqqyKWA_6zAHU53EufnPLdivuetE-4CyyqrS4BBezUGzcp2vUVuntFzaA8TXri4gCdzAh0XbxWUSSfv55ABJbYjC9gnkzUQI1qd6hTfZpV74ZobT20Sdo9juQF_1O55Pony5VerhAp4GsWk66Wa2dfL8_H0tNykwSAYXLKUUtf0R8TJiFVIy8P/s1000/img-dog-flu.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="500" data-original-width="1000" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhRrocqqyKWA_6zAHU53EufnPLdivuetE-4CyyqrS4BBezUGzcp2vUVuntFzaA8TXri4gCdzAh0XbxWUSSfv55ABJbYjC9gnkzUQI1qd6hTfZpV74ZobT20Sdo9juQF_1O55Pony5VerhAp4GsWk66Wa2dfL8_H0tNykwSAYXLKUUtf0R8TJiFVIy8P/s16000/img-dog-flu.jpg" /></a></div><span style="font-family: Public Sans; font-size: medium;"><br /></span><p></p><p><span style="font-family: Public Sans; font-size: medium;">Scientists in China have identified strains of the influenza A-H3N2 virus circulating in dogs that might be gaining the capacity to spill over into humans.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p><span style="font-family: Public Sans; font-size: medium;">Influenza-A viruses in animal reservoirs have repeatedly crossed species barriers to infect humans. H3N2 avian influenza or bird flu viruses were first transmitted to dogs around 2006 and have since formed stable canine lineages.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p><span style="font-family: Public Sans; font-size: medium;">A team from the China Agricultural University analysed swabs from more than 4,000 dogs.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p><span style="font-family: Public Sans; font-size: medium;">The findings, published in the journal eLife, showed that the H3N2 canine influenza viruses (CIVs) can recognise the human-cell receptors and hold the potential to replicate in humans.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p><span style="font-family: Public Sans; font-size: medium;">"We found that, during adaptation in dogs, H3N2 CIVs became able to recognise the human-like receptor, showed gradually increased hemagglutination (HA) acid stability and replication ability in human airway epithelial cells," they wrote in the paper.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p><span style="font-family: Public Sans; font-size: medium;">Further, they found that "human populations lack immunity to H3N2 CIVs, and even preexisting immunity derived from the present human seasonal influenza viruses cannot provide protection against H3N2 CIVs".</span></p><p><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p><span style="font-family: Public Sans; font-size: medium;">"Our results showed that canines may be intermediates for adapting avian influenza viruses to humans. Continuous surveillance coordinated with risk assessment for CIVs is necessary," the researchers said.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p><span style="font-family: Public Sans; font-size: medium;">To evaluate the infectivity and transmission ability of H3N2 CIVs in dogs, the team deliberately inoculated six dogs with the known dog flu strains.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p><span style="font-family: Public Sans; font-size: medium;">The dogs became mildly ill, with the most severe symptoms including fever, sneezing, wheezing, and coughing.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p><span style="font-family: Public Sans; font-size: medium;">While so far, there is no human infection reported with the H3N2 CIVs, the team cautioned that "dogs might increase the opportunity of viral cross-species transmission to humans".</span></p><p><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p><span style="font-family: Public Sans; font-size: medium;">According to experts, the research highlights pet dogs' role as a possible "patient zero" for a future dog flu outbreak, The Telegraph reported.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p><span style="font-family: Public Sans; font-size: medium;">It is "pretty clear" the bird flu H3 strain has become a dog-specific virus, Prof James Wood, the head of the department of veterinary medicine at the University of Cambridge, was quoted as saying.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p><span style="font-family: Public Sans; font-size: medium;">"The changes in the canine virus apparently are making it better adapted to transmit within mammals, as you might expect after such a long period in dogs," he noted.</span></p><p><span style="font-family: Public Sans; font-size: medium;"><br /></span></p><p><span style="font-family: Public Sans; font-size: medium;">**</span></p><p><span style="font-family: Public Sans; font-size: medium;">The above article has been published from a wire source with minimal modifications to the headline and text.</span></p>Dr Rohit Bhaskarhttp://www.blogger.com/profile/10470528758896957281noreply@blogger.com